Kevzara(sarilumab)
Kevzara (sarilumab) is an antibody pharmaceutical. Sarilumab was first approved as Kevzara on 2017-05-22. It is used to treat rheumatoid arthritis in the USA. It has been approved in Europe to treat rheumatoid arthritis. The pharmaceutical is active against interleukin-6 receptor subunit alpha.
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Commercial
Therapeutic Areas
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FDA
EMA
Kevzara
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| kevzara | Biologic Licensing Application | 2025-05-16 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| rheumatoid arthritis | EFO_0000685 | D001172 | M06.9 |
Agency Specific
FDA
EMA
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Patent Expiration
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Clinical
Clinical Trials
71 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 10 | 3 | 15 | 4 | 4 | 34 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 9 | 3 | 10 | 3 | 4 | 28 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | 1 | 6 | 3 | — | 2 | 10 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 2 | 2 | — | 2 | 5 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | 1 | — | 1 | 2 |
| Giant cell arteritis | D013700 | EFO_1001209 | M31.6 | — | — | 2 | — | — | 2 |
| Polymyalgia rheumatica | D011111 | EFO_0008518 | M35.3 | — | — | 2 | — | — | 2 |
| Arteritis | D001167 | EFO_0009011 | I77.6 | — | — | 1 | — | — | 1 |
| Allergic contact dermatitis | D017449 | — | L23 | — | 1 | 1 | — | — | 1 |
| Dermatitis | D003872 | — | L30.9 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 3 | — | — | — | 3 |
| Fallopian tube neoplasms | D005185 | — | — | 2 | 3 | — | — | — | 3 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | 1 | 2 |
| Recurrence | D012008 | — | — | 2 | 2 | — | — | — | 2 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 2 | 2 | — | — | — | 2 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | — | 2 | — | — | — | 2 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | 2 | — | — | — | 2 |
| Spondylarthritis | D025241 | — | — | — | 2 | — | — | — | 2 |
| Spondylitis | D013166 | — | M46.9 | — | 2 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | — | 1 |
Show 19 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | — | C34.90 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | — | — | 1 | 1 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | — | 1 | 1 |
| Mucocutaneous lymph node syndrome | D009080 | EFO_0004246 | M30.3 | — | — | — | — | 1 | 1 |
| Hyperaldosteronism | D006929 | — | E26 | — | — | — | — | 1 | 1 |
Show 18 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sarilumab |
| INN | sarilumab |
| Description | Sarilumab (human mab) |
| Classification | Antibody |
| Drug class | antiviral (arildone derivatives); monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108730 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | NU90V55F8I (ChemIDplus, GSRS) |
Target
Agency Approved
IL6R
IL6R
Alternate
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Kevzara – Regeneron Pharmaceuticals
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Estimated US medical usage
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Additional graphs summarizing 4,802 documents
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Safety
Black-box Warning
Black-box warning for: Kevzara
Adverse Events
Top Adverse Reactions
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22,156 adverse events reported
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