SIMTUZUMAB
Simtuzumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against lysyl oxidase homolog 2.
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Commercial
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Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibrosis | D005355 | — | — | 1 | 7 | — | — | — | 8 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 4 | — | — | — | 4 |
| Idiopathic pulmonary fibrosis | D054990 | — | J84.112 | 1 | 2 | — | — | — | 3 |
| Pulmonary fibrosis | D011658 | — | J84.10 | 1 | 2 | — | — | — | 3 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | 2 | — | — | — | 2 |
| Fatty liver | D005234 | EFO_0003934 | — | — | 2 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | — | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
| Essential thrombocythemia | D013920 | — | D47.3 | — | 1 | — | — | — | 1 |
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SIMTUZUMAB |
| INN | simtuzumab |
| Description | Simtuzumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109667 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 11Z5AIU653 (ChemIDplus, GSRS) |
Target
Agency Approved
LOXL2
LOXL2
Organism
Homo sapiens
Gene name
LOXL2
Gene synonyms
NCBI Gene ID
Protein name
lysyl oxidase homolog 2
Protein synonyms
lysyl oxidase related 2, lysyl oxidase-like 2 delta e13, lysyl oxidase-like 2 protein, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14
Uniprot ID
Mouse ortholog
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Alternate
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Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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