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Drug ReportsRizatriptan
Rizatriptan
Maxalt, Maxalt-mlt, Rizafilm, Rizatriptan Benzoate (rizatriptan) is a small molecule pharmaceutical. Rizatriptan was first approved as Maxalt-mlt on 1998-06-29. It is used to treat migraine disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine receptor 1B. In addition, it is known to target 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1E, and 5-hydroxytryptamine receptor 1F.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Maxalt, Maxalt-mlt, Rizatriptan benzoate (discontinued: Maxalt, Maxalt-mlt, Rizatriptan benzoate)
Combinations
Symbravo
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Rizatriptan benzoate
Tradename
Company
Number
Date
Products
MAXALT-MLTOrganonN-020865 RX1998-06-29
1 products, RLD, RS
MAXALTOrganonN-020864 RX1998-06-29
1 products, RLD, RS
Show 2 discontinued
Meloxicam
+
Rizatriptan benzoate
Tradename
Company
Number
Date
Products
SYMBRAVOAxsome TherapeuticsN-215431 RX2025-01-30
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
maxaltNew Drug Application2011-09-13
maxalt maxalt-mltNew Drug Application2022-06-01
maxalt-mltNew Drug Application2011-04-04
rizafilmNew Drug Application2024-01-10
rizatriptanANDA2024-08-29
rizatriptan benzoateANDA2025-01-27
rizatriptan benzoate odtANDA2025-01-22
rizatriptan benzoate rizatriptan benzoateANDA2021-03-02
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
migraine disordersEFO_0003821D008881G43
rheumatoid arthritisEFO_0000685D001172M06.9
osteoarthritisEFO_0002506D010003M15-M19
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Rizatriptan Benzoate, Rizafilm, Gensco
93019482034-07-30DS, DP
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CC: Selective serotonin (5ht1) agonists
— N02CC04: Rizatriptan
HCPCS
No data
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G431—15——16
HeadacheD006261—R51——4——4
EpilepsyD004827EFO_0000474G40.9——1——1
RecurrenceD012008————1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRizatriptan
INNrizatriptan
Description
Rizatriptan is a member of tryptamines. It has a role as a serotonergic agonist, a vasoconstrictor agent and an anti-inflammatory drug. It is functionally related to a N,N-dimethyltryptamine.
Classification
Small molecule
Drug classantimigraine agents (5-HT1 receptor agonists); sumatriptan derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCc1c[nH]c2ccc(Cn3cncn3)cc12
Identifiers
PDB—
CAS-ID144034-80-0
RxCUI—
ChEMBL IDCHEMBL905
ChEBI ID48273
PubChem CID5078
DrugBankDB00953
UNII ID51086HBW8G (ChemIDplus, GSRS)
Target
Agency Approved
HTR1D
HTR1D
HTR1B
HTR1B
Organism
Homo sapiens
Gene name
HTR1D
Gene synonyms
HTR1DA, HTRL
NCBI Gene ID
3352
Protein name
5-hydroxytryptamine receptor 1D
Protein synonyms
5-HT-1D, 5-HT-1D-alpha, 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled, Serotonin 1D alpha receptor, Serotonin receptor 1D
Uniprot ID
P28221
Mouse ortholog
Htr1d (15552)
5-hydroxytryptamine receptor 1D (Q8BUW7)
Alternate
HTR1A
HTR1A
HTR1E
HTR1E
HTR1F
HTR1F
Organism
Homo sapiens
Gene name
HTR1A
Gene synonyms
ADRB2RL1, ADRBRL1
NCBI Gene ID
3350
Protein name
5-hydroxytryptamine receptor 1A
Protein synonyms
5-HT1a receptor, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, G-21, guanine nucleotide-binding regulatory protein-coupled receptor, Serotonin receptor 1A
Uniprot ID
Q6LAE7
Mouse ortholog
Htr1a (15550)
5-hydroxytryptamine receptor 1A (Q8BGS4)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Rizatriptan
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,484 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,640 adverse events reported
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