Rizatriptan
Maxalt, Maxalt-mlt, Rizafilm, Rizatriptan Benzoate, Symbravo (rizatriptan) is a small molecule pharmaceutical. Rizatriptan was first approved as Maxalt-mlt on 1998-06-29. It is used to treat migraine disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine receptor 1B. In addition, it is known to target 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1E, and 5-hydroxytryptamine receptor 1F.
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Events Timeline
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1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
Maxalt, Maxalt-mlt, Rizatriptan benzoate (discontinued: Maxalt, Maxalt-mlt, Rizatriptan benzoate)
CombinationsSymbravo
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Rizatriptan benzoate
Meloxicam
+
Rizatriptan benzoate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SYMBRAVO | Axsome Therapeutics | N-215431 RX | 2025-01-30 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| maxalt | New Drug Application | 2011-09-13 |
| maxalt maxalt-mlt | New Drug Application | 2022-06-01 |
| maxalt-mlt | New Drug Application | 2011-04-04 |
| rizafilm | New Drug Application | 2024-01-10 |
| rizatriptan | ANDA | 2024-08-29 |
| rizatriptan benzoate | ANDA | 2025-02-01 |
| rizatriptan benzoate odt | ANDA | 2025-01-22 |
| rizatriptan benzoate rizatriptan benzoate | ANDA | 2021-03-02 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Rizatriptan Benzoate, Rizafilm, Gensco | |||
| 9301948 | 2034-07-30 | DS, DP | |
HCPCS
No data
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | 2 | 24 | 9 | 6 | 41 |
| Headache | D006261 | — | R51 | — | — | 5 | 3 | 1 | 9 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | 1 | 1 | — | 2 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | 1 | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | — | — | 1 | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | 1 | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | 1 | — | 1 |
| Restless legs syndrome | D012148 | EFO_0004270 | G25.81 | — | — | — | 1 | — | 1 |
| Post-concussion syndrome | D038223 | EFO_1001827 | F07.81 | — | — | — | 1 | — | 1 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine without aura | D020326 | EFO_0005296 | G43.0 | — | — | 1 | — | — | 1 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | — | — | 1 | — | — | 1 |
| Vertigo | D014717 | — | H81.39 | — | 1 | 1 | — | — | 1 |
| Recurrence | D012008 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Post-traumatic headache | D051298 | — | G44.3 | — | — | — | — | 1 | 1 |
| Motion sickness | D009041 | — | T75.3 | — | — | — | — | 1 | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rizatriptan |
| INN | rizatriptan |
| Description | Rizatriptan is a member of tryptamines. It has a role as a serotonergic agonist, a vasoconstrictor agent and an anti-inflammatory drug. It is functionally related to a N,N-dimethyltryptamine. |
| Classification | Small molecule |
| Drug class | antimigraine agents (5-HT1 receptor agonists); sumatriptan derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CCc1c[nH]c2ccc(Cn3cncn3)cc12 |
Identifiers
| PDB | — |
| CAS-ID | 144034-80-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL905 |
| ChEBI ID | 48273 |
| PubChem CID | 5078 |
| DrugBank | DB00953 |
| UNII ID | 51086HBW8G (ChemIDplus, GSRS) |
Target
Agency Approved
HTR1D
HTR1D
HTR1B
HTR1B
Organism
Homo sapiens
Gene name
HTR1D
Gene synonyms
HTR1DA, HTRL
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 1D
Protein synonyms
5-HT-1D, 5-HT-1D-alpha, 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled, Serotonin 1D alpha receptor, Serotonin receptor 1D
Uniprot ID
Mouse ortholog
Htr1d (15552)
5-hydroxytryptamine receptor 1D (Q8BUW7)
Alternate
HTR1A
HTR1A
HTR1E
HTR1E
HTR1F
HTR1F
Organism
Homo sapiens
Gene name
HTR1A
Gene synonyms
ADRB2RL1, ADRBRL1
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 1A
Protein synonyms
5-HT1a receptor, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, G-21, guanine nucleotide-binding regulatory protein-coupled receptor, Serotonin receptor 1A
Uniprot ID
Mouse ortholog
Htr1a (15550)
5-hydroxytryptamine receptor 1A (Q8BGS4)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Rizatriptan
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,525 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,621 adverse events reported
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