Rivoceranib
Rivoceranib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target proto-oncogene tyrosine-protein kinase receptor Ret, mast/stem cell growth factor receptor Kit, tyrosine-protein kinase CSK, and vascular endothelial growth factor receptor 2.
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Commercial
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Clinical
Clinical Trials
609 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 2 | 10 | 5 | 1 | 2 | 18 |
| Esophageal neoplasms | D004938 | — | C15 | — | 3 | — | 1 | 1 | 5 |
| Adenocarcinoma | D000230 | — | — | 1 | 2 | — | 1 | — | 4 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 2 | 9 | 4 | — | 1 | 14 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 8 | 6 | — | 1 | 14 |
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | 9 | 2 | — | — | 12 |
| Lung neoplasms | D008175 | — | C34.90 | 2 | 8 | 2 | — | 1 | 11 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 5 | 3 | — | — | 9 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 6 | 3 | — | 1 | 9 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 4 | 2 | — | — | 7 |
| Triple negative breast neoplasms | D064726 | — | — | 2 | 2 | 2 | — | — | 6 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 1 | 4 | 1 | — | — | 6 |
| Small cell lung carcinoma | D055752 | — | — | — | 2 | 1 | — | 1 | 4 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 8 | 2 | — | — | — | 9 |
| Colorectal neoplasms | D015179 | — | — | — | 8 | — | — | — | 8 |
| Squamous cell carcinoma | D002294 | — | — | 1 | 3 | — | — | — | 4 |
| Sarcoma | D012509 | — | — | — | 4 | — | — | — | 4 |
| Cholangiocarcinoma | D018281 | — | C22.1 | — | 4 | — | — | — | 4 |
| Osteosarcoma | D012516 | — | — | — | 3 | — | — | — | 3 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | 1 | 1 | — | — | — | 2 |
| Adenocarcinoma of lung | D000077192 | — | — | 1 | 1 | — | — | — | 2 |
| Respiratory tract diseases | D012140 | — | — | 1 | 2 | — | — | — | 2 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rivoceranib |
| INN | rivoceranib |
| Description | Apatinib, also known as rivoceranib, is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR). It is an orally bioavailable, small molecule agent which is thought to inhibit angiogenesis in cancer cells; specifically, apatinib inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. This agent also mildly inhibits c-Kit and c-SRC tyrosine kinases.
|
| Classification | Small molecule |
| Drug class | angiogenesis inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N#CC1(c2ccc(NC(=O)c3cccnc3NCc3ccncc3)cc2)CCCC1 |
Identifiers
| PDB | — |
| CAS-ID | 1218779-75-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3186534 |
| ChEBI ID | — |
| PubChem CID | 11315474 |
| DrugBank | DB14765 |
| UNII ID | 5S371K6132 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
RET
RET
Organism
Homo sapiens
Gene name
RET
Gene synonyms
CDHF12, CDHR16, PTC, RET51
NCBI Gene ID
Protein name
proto-oncogene tyrosine-protein kinase receptor Ret
Protein synonyms
Cadherin family member 12, cadherin-related family member 16, Proto-oncogene c-Ret, rearranged during transfection, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), RET receptor tyrosine kinase
Uniprot ID
Mouse ortholog
Ret (19713)
proto-oncogene tyrosine-protein kinase receptor Ret (P35546)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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11,556 adverse events reported
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