Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Carcinoma | D002277 | — | C80.0 | 7 | 86 | 17 | 2 | 18 | 121 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | 11 | 58 | 15 | 3 | 12 | 87 |
Hepatocellular carcinoma | D006528 | — | C22.0 | 7 | 50 | 14 | 1 | 19 | 80 |
Lung neoplasms | D008175 | — | C34.90 | 7 | 45 | 9 | 1 | 7 | 61 |
Non-small-cell lung carcinoma | D002289 | — | — | 4 | 31 | 7 | 2 | 5 | 45 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 30 | 8 | 1 | 2 | 42 |
Adenocarcinoma | D000230 | — | — | 8 | 29 | 5 | 1 | 2 | 39 |
Neoplasms | D009369 | — | C80 | 15 | 15 | 1 | 3 | 2 | 33 |
Squamous cell carcinoma | D002294 | — | — | 2 | 22 | — | 1 | — | 25 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 16 | 4 | 1 | 1 | 24 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 6 | 43 | 7 | — | 14 | 61 |
Small cell lung carcinoma | D055752 | — | — | 2 | 19 | 4 | — | 1 | 25 |
Colorectal neoplasms | D015179 | — | — | 4 | 18 | 1 | — | 2 | 22 |
Triple negative breast neoplasms | D064726 | — | — | 5 | 16 | 3 | — | — | 22 |
Ovarian epithelial carcinoma | D000077216 | — | — | 1 | 15 | 4 | — | 2 | 22 |
Recurrence | D012008 | — | — | — | 16 | 1 | — | 3 | 20 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | 11 | 2 | — | 1 | 13 |
Nasopharyngeal carcinoma | D000077274 | — | — | 1 | 10 | 2 | — | — | 13 |
Nasopharyngeal neoplasms | D009303 | — | — | 1 | 10 | 2 | — | — | 13 |
Osteosarcoma | D012516 | — | — | — | 9 | 1 | — | 1 | 10 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Esophageal squamous cell carcinoma | D000077277 | — | — | 1 | 15 | — | — | — | 16 |
Sarcoma | D012509 | — | — | 1 | 14 | — | — | 1 | 16 |
Cholangiocarcinoma | D018281 | — | C22.1 | — | 9 | — | — | 2 | 11 |
Biliary tract neoplasms | D001661 | — | C24.9 | 1 | 10 | — | — | — | 10 |
Neoadjuvant therapy | D020360 | — | — | — | 8 | — | — | 1 | 9 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 8 | — | — | — | 8 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 7 | — | — | — | 8 |
Glioma | D005910 | EFO_0000520 | — | 1 | 5 | — | — | 1 | 6 |
Adenocarcinoma of lung | D000077192 | — | — | 1 | 4 | — | — | — | 5 |
Head and neck neoplasms | D006258 | — | — | 1 | 4 | — | — | — | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Urologic neoplasms | D014571 | — | C64-C68 | 1 | — | — | — | — | 1 |
Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Mouth neoplasms | D009062 | EFO_0003868 | C06.9 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Glioblastoma | D005909 | EFO_0000515 | — | — | — | — | — | 2 | 2 |
Disease progression | D018450 | — | — | — | — | — | — | 1 | 1 |
Adjuvant chemotherapy | D017024 | — | — | — | — | — | — | 1 | 1 |
Fatal outcome | D017809 | — | — | — | — | — | — | 1 | 1 |
Meningioma | D008579 | EFO_0003098 | D32.9 | — | — | — | — | 1 | 1 |
Chondrosarcoma | D002813 | — | — | — | — | — | — | 1 | 1 |
Catheter ablation | D017115 | — | — | — | — | — | — | 1 | 1 |
Radiotherapy | D011878 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Rivoceranib |
INN | rivoceranib |
Description | Apatinib, also known as rivoceranib, is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR). It is an orally bioavailable, small molecule agent which is thought to inhibit angiogenesis in cancer cells; specifically, apatinib inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. This agent also mildly inhibits c-Kit and c-SRC tyrosine kinases.
|
Classification | Small molecule |
Drug class | angiogenesis inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | N#CC1(c2ccc(NC(=O)c3cccnc3NCc3ccncc3)cc2)CCCC1 |
PDB | — |
CAS-ID | 1218779-75-9 |
RxCUI | — |
ChEMBL ID | CHEMBL3186534 |
ChEBI ID | — |
PubChem CID | 11315474 |
DrugBank | DB14765 |
UNII ID | 5S371K6132 (ChemIDplus, GSRS) |