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Drug ReportsRisperidone
Risperdal, Okedi(risperidone)
Okedi, Perseris, Risperdal, Risperidone, Risvan, Rykindo, Uzedy (risperidone) is a small molecule pharmaceutical. Risperidone was first approved as Risperdal on 1993-12-29. It is used to treat autistic disorder, bipolar disorder, dementia, schizophrenia, and schizophrenia spectrum and other psychotic disorders amongst others in the USA. It has been approved in Europe to treat schizophrenia. The pharmaceutical is active against 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1B, D(2) dopamine receptor, and 5-hydroxytryptamine receptor 1D. In addition, it is known to target 5-hydroxytryptamine receptor 1F, D(3) dopamine receptor, 5-hydroxytryptamine receptor 1A, alpha-1D adrenergic receptor, 5-hydroxytryptamine receptor 7, alpha-1B adrenergic receptor, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 6, alpha-1A adrenergic receptor, histamine H1 receptor, and 5-hydroxytryptamine receptor 1E.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
mental disordersD001523
Trade Name
FDA
EMA
Perseris, Risperdal, Risperidone, Rykindo, Uzedy (discontinued: Risperdal, Risperidone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Risperidone
Tradename
Company
Number
Date
Products
PERSERIS KITIndiviorN-210655 RX2018-07-27
2 products, RLD, RS
RISPERDALJohnson & JohnsonN-020272 RX1993-12-29
6 products, RLD
RISPERDALJohnson & JohnsonN-020588 RX1996-06-10
1 products, RLD, RS
RISPERDAL CONSTAJohnson & JohnsonN-021346 RX2003-10-29
4 products, RLD
RYKINDOShandong Luye PharmaceuticalN-212849 RX2023-01-13
4 products, RLD
UZEDYTevaN-213586 RX2023-04-28
7 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
perserisNew Drug Application2024-11-11
risperdalNew Drug Application2010-12-27
risperdal constaNew Drug Application2024-10-02
risperdal risperdal m-tabNew Drug Application2022-08-31
risperdal risperdal m-tab risperdal oral solution2006-05-10
risperidoneANDA2025-01-07
risperidone oral disintegrate tabletsANDA2010-08-18
risperidone risperidone m-tabNew Drug Application2022-09-14
risvanNew Drug Application2024-03-29
rykindoNew Drug Application2023-06-09
Show 1 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
dementiaEFO_0003862D003704F03
tourette syndromeEFO_0004895D005879F95.2
schizophreniaEFO_0000692D012559F20
bipolar disorderEFO_0000289D001714F30.9
autistic disorderHP_0000717D001321F84.0
schizophrenia spectrum and other psychotic disorders—D019967—
Agency Specific
FDA
EMA
Expiration
Code
RISPERIDONE, UZEDY, TEVA
2026-04-28NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Risperidone, Uzedy, Teva
90238972033-04-05DP
82217782027-11-12DPU-543
87413272027-11-12DPU-543
88021272025-01-12DP
94399052025-01-12DPU-543
97177992025-01-12DP
98954472025-01-12DP
99252682025-01-12DP
107369652025-01-12DP
Risperidone, Rykindo, Shandong Luye
94461352032-04-10DPU-3513
95329912032-04-10DPU-3513
100988822032-04-10DPU-3513
104061612032-04-10DPU-3513
111100942032-04-10DP
Risperidone, Perseris Kit, Indivior
91801972028-02-13DP
91864132028-02-13U-543
100106122028-02-13DP
103765902028-02-13U-2608
110138092028-02-13DPU-3135
111100932026-11-05DPU-3135
95974022026-09-26DP
100585542026-09-26U-2363
104061602026-06-26DPU-2608
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AX: Other antipsychotics in atc
— N05AX08: Risperidone
HCPCS
Code
Description
J2794
Injection, risperidone (risperdal consta), 0.5 mg
J2798
Injection, risperidone, (perseris), 0.5 mg
Clinical
Clinical Trials
584 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20——2——2
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
MalnutritionD044342EFO_0008572E40-E461————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRisperidone
INNrisperidone
Description
Risperidone is a member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2. It has a role as a serotonergic antagonist, an alpha-adrenergic antagonist, a H1-receptor antagonist, a second generation antipsychotic, a dopaminergic antagonist, a psychotropic drug and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is a pyridopyrimidine, an organofluorine compound, a heteroarylpiperidine and a member of 1,2-benzoxazoles.
Classification
Small molecule
Drug classantipsychotics (risperidone type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2
Identifiers
PDB—
CAS-ID106266-06-2
RxCUI—
ChEMBL IDCHEMBL85
ChEBI ID8871
PubChem CID5073
DrugBankDB00734
UNII IDL6UH7ZF8HC (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
146
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Q9NPY0
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (P97714)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Risperdal – Alkermes
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Risperdal – Johnson & Johnson
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Estimated US medical usage
Risperidone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 28,079 documents
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Safety
Black-box Warning
Black-box warning for: Perseris, Risperdal, Risperdal consta, Risperdal risperdal m-tab, Risperdal risperdal m-tab risperdal oral solution, Risperidone, Risperidone oral disintegrate tablets, Risperidone risperidone m-tab, Risvan, Rykindo, Uzedy
Adverse Events
Top Adverse Reactions
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105,304 adverse events reported
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