Rilutek(riluzole)
Exservan, Rilutek, Riluzole, Tiglutik (riluzole) is a small molecule pharmaceutical. Riluzole was first approved as Rilutek on 1995-12-12. It is used to treat amyotrophic lateral sclerosis in the USA. It has been approved in Europe to treat amyotrophic lateral sclerosis. It is known to target intermediate conductance calcium-activated potassium channel protein 4, potassium voltage-gated channel subfamily H member 2, short transient receptor potential channel 5, small conductance calcium-activated potassium channel protein 3, potassium voltage-gated channel subfamily D member 2, potassium channel subfamily K member 2, small conductance calcium-activated potassium channel protein 1, small conductance calcium-activated potassium channel protein 2, potassium voltage-gated channel subfamily D member 3, and potassium channel subfamily K member 4.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| nutritional and metabolic diseases | D009750 |
Trade Name
FDA
EMA
Exservan, Rilutek, Tiglutik (generic drugs available since 2003-01-29)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Riluzole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EXSERVAN | Aquestive Therapeutics | N-212640 RX | 2019-11-22 | 1 products, RLD, RS |
| RILUTEK | Covis Pharma | N-020599 RX | 1995-12-12 | 1 products, RLD, RS |
| TIGLUTIK KIT | Italfarmaco | N-209080 RX | 2018-09-05 | 1 products, RLD, RS |
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| amyotrophic lateral sclerosis | EFO_0000253 | D000690 | G12.21 |
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
86 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | 4 | 25 | 9 | 2 | 4 | 36 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | 1 | — | 1 |
| Fatigue | D005221 | HP_0012378 | R53.83 | — | — | — | 1 | — | 1 |
| Tourette syndrome | D005879 | EFO_0004895 | F95.2 | — | — | — | 1 | — | 1 |
| Fragile x syndrome | D005600 | — | Q99.2 | — | — | — | 1 | — | 1 |
| Memory disorders | D008569 | — | — | — | — | — | 1 | — | 1 |
| Affect | D000339 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | 2 | 1 | — | 1 | 3 |
| Cerebellar ataxia | D002524 | HP_0001251 | — | — | 2 | 1 | — | — | 2 |
| Spinocerebellar ataxias | D020754 | HP_0007263 | — | — | — | 1 | — | — | 1 |
| Neuromuscular diseases | D009468 | EFO_1001902 | G70.9 | — | 1 | 1 | — | — | 1 |
| Social phobia | D000072861 | EFO_1001917 | F40.1 | — | 1 | 1 | — | — | 1 |
| Performance anxiety | D060805 | — | — | — | 1 | 1 | — | — | 1 |
| Huntington disease | D006816 | Orphanet_399 | G10 | — | — | 1 | — | — | 1 |
| Multiple system atrophy | D019578 | — | — | — | — | 1 | — | — | 1 |
| Progressive supranuclear palsy | D013494 | EFO_0002512 | G23.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | 1 | 2 | — | — | 1 | 4 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 3 | — | — | 1 | 4 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 3 | 1 | — | — | — | 3 |
| Melanoma | D008545 | — | — | 2 | 1 | — | — | — | 3 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 2 | — | — | — | 2 |
| Depression | D003863 | — | F33.9 | — | 2 | — | — | — | 2 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | — | 2 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | — | 1 |
| Chronic progressive multiple sclerosis | D020528 | EFO_0003840 | — | — | 1 | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Treatment-resistant schizophrenia | D000090663 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Riluzole |
| INN | riluzole |
| Description | Riluzole is a member of benzothiazoles. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc2ccc(OC(F)(F)F)cc2s1 |
Identifiers
| PDB | — |
| CAS-ID | 1744-22-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL744 |
| ChEBI ID | 8863 |
| PubChem CID | 5070 |
| DrugBank | DB00740 |
| UNII ID | 7LJ087RS6F (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNK2
KCNK2
KCNH2
KCNH2
KCNN2
KCNN2
CALM1
CALM1
Organism
Homo sapiens
Gene name
KCNK2
Gene synonyms
TREK, TREK1
NCBI Gene ID
Protein name
potassium channel subfamily K member 2
Protein synonyms
K2P2.1 potassium channel, Outward rectifying potassium channel protein TREK-1, potassium channel, two pore domain subfamily K, member 2, potassium inwardly-rectifying channel, subfamily K, member 2, tandem-pore-domain potassium channel TREK-1, TREK-1 K(+) channel subunit, TWIK-related potassium channel 1, Two pore domain potassium channel TREK-1, Two pore potassium channel TPKC1, two-pore potassium channel 1
Uniprot ID
Mouse ortholog
Kcnk2 (16526)
potassium channel subfamily K member 2 (Q4VQI2)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,226 adverse events reported
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