Rilotumumab
Rilotumumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against hepatocyte growth factor.
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Commercial
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Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 2 | 2 | 2 | — | — | 5 |
| Carcinoma | D002277 | — | C80.0 | — | 3 | 1 | — | 1 | 4 |
| Adenocarcinoma | D000230 | — | — | 1 | 2 | 1 | — | — | 3 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 2 | 1 | — | 1 | 3 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | — | 1 | — | — | 2 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | — | 1 | — | — | 2 |
| Squamous cell carcinoma | D002294 | — | — | — | 1 | 1 | — | 1 | 2 |
| Squamous cell neoplasms | D018307 | — | — | — | 1 | 1 | — | 1 | 2 |
| Philadelphia chromosome | D010677 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 3 | 3 | — | — | — | 4 |
| Recurrence | D012008 | — | — | — | 2 | — | — | — | 2 |
| Glioma | D005910 | EFO_0000520 | — | — | 2 | — | — | — | 2 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | 2 | — | — | — | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | 1 | — | — | — | 1 |
| Gliosarcoma | D018316 | — | — | — | 1 | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | — | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | 1 | 1 | — | — | — | 1 |
| Colonic neoplasms | D003110 | — | C18 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Biphenotypic leukemia acute | D015456 | — | C95.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rilotumumab |
| INN | rilotumumab |
| Description | Rilotumumab (human mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743063 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 51WEW898IJ (ChemIDplus, GSRS) |
Target
Agency Approved
HGF
HGF
Organism
Homo sapiens
Gene name
HGF
Gene synonyms
HPTA
NCBI Gene ID
Protein name
hepatocyte growth factor
Protein synonyms
fibroblast-derived tumor cytotoxic factor, hepatocyte growth factor (hepapoietin A; scatter factor), Hepatopoietin-A, lung fibroblast-derived mitogen, Scatter factor, SF
Uniprot ID
Mouse ortholog
Hgf (15234)
hepatocyte growth factor (Q6LBE6)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 994 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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51 adverse events reported
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