Riboflavin
Infuvite, M.v.i, Vitaped (riboflavin) is a small molecule pharmaceutical. Riboflavin was first approved as M.v.i.-12 adult on 1985-08-08. It is used to treat riboflavin deficiency in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
Trade Name
FDA
EMA
Combinations
Infuvite (discontinued: M.v.i., Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 25 person ansi | OTC monograph final | 2010-06-07 |
| 50 person ansi | OTC monograph final | 2010-06-07 |
| adult infuvite multiple vitamins | New Drug Application | 2019-05-14 |
| adult infuvite multiple vitamins for infusion pharmacy bulk | New Drug Application | 2013-01-01 |
| arc first aid emergency preparedness contains 167 pieces | OTC monograph final | 2010-06-07 |
| aronamin gold | unapproved drug other | 2018-12-12 |
| b-plex 100 | unapproved drug other | 2020-12-04 |
| bacmin | unapproved drug other | 2014-05-02 |
| bal-care dha | unapproved drug other | 2012-05-01 |
| bal-care dha essential | unapproved drug other | 2012-05-01 |
Show 152 more
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| riboflavin deficiency | HP_0100504 | D012257 | E53.0 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11H: Other plain vitamin preparations in atc
— A11HA: Other plain vitamin preparations in atc
— A11HA04: Riboflavin (vit b2)
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA26: Riboflavin
HCPCS
Code | Description |
|---|---|
| J2787 | Riboflavin 5'-phosphate, ophthalmic solution, up to 3 ml |
Clinical
Clinical Trials
2314 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 50 | 175 | 85 | 6 | 6 | 295 |
| Keratoconus | D007640 | EFO_0004223 | H18.6 | 9 | 22 | 32 | 3 | 40 | 95 |
| Neoplasms | D009369 | — | C80 | 52 | 28 | 9 | 1 | 4 | 82 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 16 | 45 | 12 | 2 | 5 | 70 |
| Adenocarcinoma | D000230 | — | — | 14 | 33 | 15 | 1 | — | 54 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 4 | 14 | 13 | 4 | 21 | 51 |
| Healthy volunteers/patients | — | — | — | 15 | 4 | — | 1 | 27 | 46 |
| Esophageal neoplasms | D004938 | — | C15 | 7 | 27 | 5 | 1 | 1 | 35 |
| Anemia | D000740 | HP_0001903 | D64.9 | 4 | 1 | 7 | 4 | 19 | 34 |
| Covid-19 | D000086382 | — | U07.1 | 2 | 9 | 11 | 2 | 9 | 31 |
Show 109 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 45 | 72 | 15 | — | 2 | 112 |
| Rectal neoplasms | D012004 | — | — | 19 | 38 | 11 | — | 1 | 65 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 11 | 24 | 17 | — | — | 45 |
| Colonic neoplasms | D003110 | — | C18 | 16 | 21 | 13 | — | 2 | 45 |
| Non-small-cell lung carcinoma | D002289 | — | — | 12 | 16 | 9 | — | — | 30 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 6 | 17 | 6 | — | 3 | 26 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 1 | 3 | — | 19 | 23 |
| Pancreatic ductal carcinoma | D021441 | — | — | 9 | 11 | 3 | — | — | 21 |
| Leukemia | D007938 | — | C95 | 3 | 10 | 8 | — | 1 | 21 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | 2 | 1 | 1 | — | 16 | 20 |
Show 133 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 9 | 9 | — | — | 3 | 18 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 9 | 9 | — | — | — | 15 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | 3 | — | — | 10 | 14 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 9 | 5 | — | — | 1 | 13 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 5 | 9 | — | — | 1 | 13 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 9 | 5 | — | — | — | 12 |
| Biliary tract neoplasms | D001661 | — | C24.9 | 2 | 12 | — | — | — | 12 |
| Gallbladder neoplasms | D005706 | EFO_0004606 | C23 | 6 | 7 | — | — | — | 11 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 7 | 3 | — | — | — | 9 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 4 | 7 | — | — | 1 | 9 |
Show 146 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood pressure | D001794 | EFO_0004325 | — | 1 | — | — | — | 4 | 5 |
| Fallopian tube neoplasms | D005185 | — | — | 3 | — | — | — | 1 | 4 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | 3 | 4 |
| Birth weight | D001724 | EFO_0004344 | — | 1 | — | — | — | 3 | 4 |
| Nutritional status | D009752 | — | — | 1 | — | — | — | 2 | 3 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 1 | — | — | — | 1 | 2 |
| Follicular lymphoma | D008224 | — | C82 | 2 | — | — | — | — | 2 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 2 | — | — | — | — | 2 |
| Abdominal obesity | D056128 | HP_0001956 | — | 1 | — | — | — | 1 | 2 |
| Biological availability | D001682 | — | — | 1 | — | — | — | 1 | 2 |
Show 50 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Weight loss | D015431 | HP_0001824 | — | — | — | — | — | 4 | 4 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | — | — | 4 | 4 |
| Folic acid deficiency | D005494 | EFO_0001070 | E53.8 | — | — | — | — | 4 | 4 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | — | — | 4 | 4 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | — | — | — | 4 | 4 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | — | 4 | 4 |
| Avitaminosis | D001361 | EFO_0005878 | E56.9 | — | — | — | — | 3 | 3 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 3 | 3 |
| Dietary supplements | D019587 | — | — | — | — | — | — | 3 | 3 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | — | — | — | 3 | 3 |
Show 172 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Riboflavin |
| INN | riboflavin |
| Description | Riboflavin is d-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety. It is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables, but the richest natural source is yeast. The free form occurs only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. It has a role as a photosensitizing agent, a food colouring, an Escherichia coli metabolite, a mouse metabolite, a cofactor, a plant metabolite, a human urinary metabolite, an anti-inflammatory agent, a fundamental metabolite and an antioxidant. It is a vitamin B2 and a flavin. It is a conjugate acid of a riboflavin(1-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)CO)c2cc1C |
Identifiers
| PDB | — |
| CAS-ID | 83-88-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1534 |
| ChEBI ID | 17015 |
| PubChem CID | 493570 |
| DrugBank | DB00140 |
| UNII ID | TLM2976OFR (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Riboflavin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 50,974 documents
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Safety
Black-box Warning
Black-box warning for: Citranatal 90 dha, Citranatal assure, Citranatal dha, Citranatal essence, Citranatal rx, Healthy mamabe well rounded, Marnatal f, Moms choice rx, Natafort, Neonatal complete, Neonatal dha, Neonatal19, Nestabs, Nestabs dha, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenata, Prenatal plus multivitamin plus dha minicaps, Prenate elite, Primacare, Select ob, Select-ob plus dha, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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1,421 adverse events reported
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