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Drug ReportsRiboflavin
Riboflavin
Infuvite, M.v.i, Vitaped (riboflavin) is a small molecule pharmaceutical. Riboflavin was first approved as M.v.i.-12 adult on 1985-08-08. It is used to treat riboflavin deficiency in the USA.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
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3M
6M
YTD
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2Y
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FDA approval date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Photrexa viscous in dextran
Combinations
Infuvite (discontinued: Berocca pn, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE PEDIATRICSandozN-021265 RX2001-02-21
1 products, RLD, RS
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)SandozN-021265 RX2004-01-29
1 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
VITAPEDHospiraN-020176 DISCN1993-12-29
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I. PEDIATRICHospiraN-018920 DISCN2000-09-21
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
BEROCCA PNRocheN-006071 DISCN1985-10-10
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.C. 9+3APP PharmaceuticalsN-018440 DISCN1985-08-08
1 products
M.V.I.-12 ADULTHospiraN-008809 DISCN1985-08-08
2 products
MVC PLUSAllerganN-018439 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 ADULTHospiraN-008809 DISCN2004-04-22
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 LYOPHILIZEDTeligentN-018933 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Tradename
Company
Number
Date
Products
M.V.I. ADULTHospiraN-021625 DISCN2004-01-30
1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)HospiraN-021643 DISCN2004-02-18
1 products, RLD
Hide discontinued
Riboflavin 5'-phosphate
Tradename
Company
Number
Date
Products
PHOTREXAGlaukosN-203324 RX2016-04-15
1 products, RLD, RS
PHOTREXA VISCOUS IN DEXTRAN 20%GlaukosN-203324 RX2016-04-15
1 products, RLD, RS
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE ADULTSandozN-021163 RX2000-05-18
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
25 person ansiOTC monograph final2010-06-07
50 person ansiOTC monograph final2010-06-07
adult infuvite multiple vitaminsNew Drug Application2019-05-14
arc first aid emergency preparedness contains 167 piecesOTC monograph final2010-06-07
aronamin goldunapproved drug other2018-12-12
bacminunapproved drug other2014-05-02
bio no brain care (helps improve brain blood flow and body temperature, fermented garlic powder)unapproved drug other2025-03-14
bio no more yeast infection (helps improve vaginal yeast infection, fermented cabbage powder)unapproved drug other2025-03-14
biovitaunapproved drug other2019-01-14
body glove for men antibacterial hand sanitizer tea tree and vitamin e scentedOTC monograph not final2020-11-13
Show 147 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11H: Other plain vitamin preparations in atc
— A11HA: Other plain vitamin preparations in atc
— A11HA04: Riboflavin (vit b2)
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA26: Riboflavin
HCPCS
Code
Description
J2787
Riboflavin 5'-phosphate, ophthalmic solution, up to 3 ml
Clinical
Clinical Trials
2545 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD015179——672069469349
AdenocarcinomaD000230——531033911172
NeoplasmsD009369—C8076552019139
KeratoconusD007640EFO_0004223H18.6102334445104
Stomach neoplasmsD013274EFO_0003897C162059152791
Esophageal neoplasmsD004938—C151648102266
Diabetes mellitusD003920EFO_0000400E08-E134131653366
LymphomaD008223—C85.92238112165
SyndromeD013577——1417872765
Type 2 diabetes mellitusD003924EFO_0001360E115171562865
Show 175 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C25498822—2135
LeukemiaD007938—C95224428—284
Rectal neoplasmsD012004——205013—281
CarcinomaD002277—C80.0294318—274
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.0113125—262
Colonic neoplasmsD003110—C18162426—261
Lymphoid leukemiaD007945—C91112923—258
RecurrenceD012008——19235—446
Non-small-cell lung carcinomaD002289——24239——44
Lung neoplasmsD008175—C34.9012209—234
Show 207 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C501914——532
Ovarian neoplasmsD010051EFO_0003893C56117——117
CholangiocarcinomaD018281—C22.1512——117
AgingD000375GO_0007568R41.8113——1216
DepressionD003863—F33.914——914
Myelodysplastic syndromesD009190—D46106———13
Myeloid leukemia acuteD015470—C92.0114———13
PreleukemiaD011289——105———12
Gallbladder neoplasmsD005706EFO_0004606C2357———11
Alzheimer diseaseD000544EFO_0000249F0357——211
Show 228 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.91———56
Blood pressureD001794EFO_0004325—1———45
ConstipationD003248—K59.01———45
Sleep apnea syndromesD012891EFO_0003877G47.32———13
Abdominal obesityD056128——1———23
PharmacokineticsD010599——2———13
Nutritional statusD009752——1———23
Biological availabilityD001682——2———13
Obstructive lung diseasesD008173——1———23
Skin diseasesD012871—L00-L992———13
Show 74 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Weight lossD015431——————66
Folic acid deficiencyD005494EFO_0001070E53.8————66
Open-angle glaucomaD005902EFO_0004190H40.1————55
Alopecia areataD000506EFO_0004192L63————55
AlopeciaD000505—L64————55
Bone diseasesD001847—M89.9————44
Bone fracturesD050723EFO_0003931T14.8————44
MenopauseD008593EFO_0003922N95————44
ExerciseD015444EFO_0000483—————44
Dietary supplementsD019587——————44
Show 262 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRiboflavin
INNriboflavin
Description
Riboflavin is d-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety. It is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables, but the richest natural source is yeast. The free form occurs only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. It has a role as a photosensitizing agent, a food colouring, an Escherichia coli metabolite, a mouse metabolite, a cofactor, a plant metabolite, a human urinary metabolite, an anti-inflammatory agent, a fundamental metabolite and an antioxidant. It is a vitamin B2 and a flavin. It is a conjugate acid of a riboflavin(1-).
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)CO)c2cc1C
Identifiers
PDB—
CAS-ID83-88-5
RxCUI—
ChEMBL IDCHEMBL1534
ChEBI ID17015
PubChem CID493570
DrugBankDB00140
UNII IDTLM2976OFR (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Riboflavin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 58,301 documents
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Safety
Black-box Warning
Black-box warning for: Citranatal assure, Citranatal dha, Citranatal essence, Citranatal rx, Healthy mamabe well rounded, Marnatal f, Moms choice rx, Natafort, Nestabs, Nestabs dha, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenata, Prenate elite, Select ob, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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2,689 adverse events reported
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