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Drug ReportsReserpine
Reserpine
Cam-ap-es, Demi-regroton, Diupres, Diutensen-r, Dralserp, H.r, Hiserpia, Hydrap-es, Hydro-reserp, Hydro-serp, Hydromox, Hydropres, Hydroserpine (r), Metatensin, Naqua, Naquival, Rau-sed, Regroton, Renese-r, Salutensin, Salutensin-demi, Sandril, Ser-a-gen, Ser-ap-es, Serpalan, Serpanray, Serpasil, Serpasil-apresoline, Serpasil-esidrix, Serpate, Serpivite, Unipres (reserpine) is a small molecule pharmaceutical. Reserpine was first approved as Chlorothiazide w/ reserpine on 1982-01-01. It is used to treat dyskinesias, hypertension, and schizophrenia in the USA. The pharmaceutical is active against synaptic vesicular amine transporter. In addition, it is known to target chromaffin granule amine transporter.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Reserpine
Tradename
Company
Number
Date
Products
HISERPIABowman PharmaceuticalsN-009631 DISCN1982-01-01
2 products
RAU-SEDBristol Myers SquibbN-009357 DISCN1982-01-01
4 products
RESERPINECM BundyN-009663 DISCN1982-01-01
2 products
RESERPINECycle PharmaceuticalsN-009859 DISCN1982-01-01
2 products
RESERPINEEveryLife Foundation for Rare DiseasesN-010441 DISCN1982-01-01
4 products
RESERPINEImpax LaboratoriesN-009627 DISCN1982-01-01
2 products
RESERPINETevaN-011185 DISCN1982-01-01
2 products
SERPALANLannettN-010124 DISCN1982-01-01
2 products
SANDRILEli LillyN-009376 DISCN1982-01-01
2 products
SANDRILEli LillyN-010012 DISCN1982-01-01
1 products
SERPASILNovartisN-009115 DISCN1982-01-01
4 products
SERPASILNovartisN-009434 DISCN1982-01-01
1 products
SERPANRAYPanray CorporationN-009391 DISCN1982-01-01
3 products
RESERPINESandozN-009838 DISCN1982-01-01
2 products, RLD
SERPATEVale ChemicalN-009453 DISCN1982-01-01
2 products
RESERPINEBausch Health CompaniesN-009667 DISCN1982-01-01
2 products
SERPIVITEVitarine PharmaceuticalsN-009645 DISCN1982-01-01
1 products
Hide discontinued
Hydralazine hydrochloride
+
Hydrochlorothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
SER-AP-ESNovartisN-012193 DISCN1982-01-01
1 products
Hide discontinued
Hydralazine hydrochloride
+
Reserpine
Tradename
Company
Number
Date
Products
SERPASIL-APRESOLINENovartisN-009296 DISCN1982-01-01
2 products
Hide discontinued
Hydrochlorothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
HYDROPRES 25Merck & CoN-011958 DISCN1982-01-01
1 products
HYDROPRES 50Merck & CoN-011958 DISCN1982-01-01
1 products
SERPASIL-ESIDRIX #1NovartisN-011878 DISCN1982-01-01
1 products
SERPASIL-ESIDRIX #2NovartisN-011878 DISCN1982-01-01
1 products
Hide discontinued
Chlorthalidone
+
Reserpine
Tradename
Company
Number
Date
Products
REGROTONSanofiN-015103 DISCN1982-01-01
1 products
DEMI-REGROTONSanofiN-015103 DISCN1982-01-01
1 products
Hide discontinued
Reserpine
+
Trichlormethiazide
Tradename
Company
Number
Date
Products
METATENSIN #2SanofiN-012972 DISCN1982-01-01
1 products
METATENSIN #4SanofiN-012972 DISCN1982-01-01
1 products
NAQUIVALMerck & CoN-012265 DISCN1982-01-01
1 products
Hide discontinued
Chlorothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
DIUPRES-250Merck & CoN-011635 DISCN1987-08-26
1 products
DIUPRES-500Merck & CoN-011635 DISCN1987-08-26
1 products
Hide discontinued
Trichlormethiazide
Tradename
Company
Number
Date
Products
NAQUAMerck & CoN-012265 DISCN1982-01-01
2 products
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Polythiazide
+
Reserpine
Tradename
Company
Number
Date
Products
RENESE-RPfizerN-013636 DISCN1982-01-01
1 products
Hide discontinued
Quinethazone
+
Reserpine
Tradename
Company
Number
Date
Products
HYDROMOX RLederle LaboratoriesN-013927 DISCN1982-01-01
1 products
Hide discontinued
Methyclothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
DIUTENSEN-RMedpointe Pharm HlcN-012708 DISCN1982-01-01
1 products
Hide discontinued
Hydroflumethiazide
+
Reserpine
Tradename
Company
Number
Date
Products
SALUTENSINShireN-012359 DISCN1982-01-01
1 products
SALUTENSIN-DEMIShireN-012359 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
renese-r2006-02-06
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
pulmonary hypertensionEFO_0001361D006976I27.20
nephrotic syndromeEFO_0004255D009404N04
edema—D004487R60.9
dyskinesias—D020820G24
malignant hypertensionEFO_1001031D006974—
schizophreniaEFO_0000692D012559F20
glomerulonephritis—D005921N05
liver cirrhosisEFO_0001422D008103K74.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02A: Antiadrenergic agents, centrally acting
— C02AA: Rauwolfia alkaloids, centrally acting antiadrenergic
— C02AA02: Reserpine
— C02AA52: Reserpine, combinations
— C02L: Antihypertensives and diuretics in combination
— C02LA: Rauwolfia alkaloids and diuretics in combination
— C02LA01: Reserpine and diuretics
— C02LA51: Reserpine and diuretics, combinations with other drugs
— C02LA71: Reserpine and diuretics, combinations with psycholeptics
HCPCS
No data
Clinical
Clinical Trials
174 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I102231311
Postoperative painD010149—G89.18—33217
Diabetes mellitusD003920EFO_0000400E08-E13——1146
Type 2 diabetes mellitusD003924EFO_0001360E11——1135
AnesthesiaD000758——1——135
Kidney diseasesD007674EFO_0003086N08———134
Congenital abnormalitiesD000013EFO_0003915Q89.911—113
Chronic renal insufficiencyD051436—N18———123
Heart diseasesD006331EFO_0003777I51.9—111—3
Hiv infectionsD015658EFO_0000764B20———112
Show 23 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiovascular diseasesD002318EFO_0000319I98—12—25
HypercholesterolemiaD006937————1—23
DepressionD003863—F33.91—1—13
Systemic lupus erythematosusD008180EFO_0002690M321—1—13
AtherosclerosisD050197EFO_0003914I25.1——1—12
Overactive urinary bladderD053201EFO_1000781N32.81——2——2
Ectopic pregnancyD011271—O00111——2
Premature cardiac complexesD005117—I49.40111——2
Major depressive disorderD003865EFO_0003761F22——1—12
Depressive disorderD003866EFO_1002014F32.A——1—12
Show 10 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SyndromeD013577——22——47
Wounds and injuriesD014947—T14.8—2——13
Traumatic brain injuriesD000070642—S06—1——12
Brain injuriesD001930—S06.9—1——12
LeukemiaD007938—C95—2———2
Myelodysplastic syndromesD009190—D46—2———2
Myeloid leukemia acuteD015470—C92.0—2———2
Non-hodgkin lymphomaD008228—C85.9—2———2
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.0—2———2
B-cell chronic lymphocytic leukemiaD015451—C91.1—2———2
Show 28 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD015179——1———34
Prostatic neoplasmsD011471—C611———23
AnxietyD001007EFO_0005230F41.11———23
Renal insufficiencyD051437—N191———23
HemorrhageD006470MP_0001914R581———12
PainD010146EFO_0003843R521———12
Pulmonary arterial hypertensionD000081029——1———12
Sleep initiation and maintenance disordersD007319—F51.011———12
Healthy volunteers/patients———2————2
Anxiety disordersD001008EFO_0006788F41.11———12
Show 38 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382—U07.1————77
InfectionsD007239EFO_0000544—————44
Communicable diseasesD003141——————44
Breast neoplasmsD001943EFO_0003869C50————44
NeoplasmsD009369—C80————44
Lung neoplasmsD008175—C34.90————44
Type 1 diabetes mellitusD003922EFO_0001359E10————33
Down syndromeD004314EFO_0001064Q90————33
SepsisD018805EFO_0001420A41.9————33
PneumoniaD011014EFO_0003106J18————33
Show 180 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameReserpine
INNreserpine
Description
Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. It has a role as an antihypertensive agent, a first generation antipsychotic, an adrenergic uptake inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an environmental contaminant, a xenobiotic and a plant metabolite. It is an alkaloid ester, a methyl ester and a yohimban alkaloid. It is functionally related to a reserpic acid.
Classification
Small molecule
Drug classtricyclic compounds; Rauwolfia alkaloid derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC
Identifiers
PDB—
CAS-ID50-55-5
RxCUI—
ChEMBL IDCHEMBL772
ChEBI ID28487
PubChem CID5770
DrugBankDB00206
UNII ID8B1QWR724A (ChemIDplus, GSRS)
Target
Agency Approved
SLC18A2
SLC18A2
Organism
Homo sapiens
Gene name
SLC18A2
Gene synonyms
SVMT, VMAT2
NCBI Gene ID
6571
Protein name
synaptic vesicular amine transporter
Protein synonyms
monoamine neurotransmitter transporter, Monoamine transporter, solute carrier family 18 (vesicular monoamine transporter), member 2, Solute carrier family 18 member 2, synaptic vesicle amine transporter, brain, synaptic vesicle monoamine transporter, brain, VAT2, vesicle monoamine transporter type 2, vesicle monoamine/H+ antiporter, Vesicular amine transporter 2
Uniprot ID
Q9H3P6
Mouse ortholog
Slc18a2 (214084)
synaptic vesicular amine transporter (Q8CC55)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
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Estimated US medical usage
Reserpine
+
Hydrochlorothiazide
+
Hydralazine
Total medical expenditures per year (USD, in millions)
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Reserpine
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Hydrochlorothiazide
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Reserpine
+
Hydroflumethiazide
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Reserpine
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Polythiazide
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Reserpine
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,978 documents
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Safety
Black-box Warning
Black-box warning for: Renese-r
Adverse Events
Top Adverse Reactions
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77 adverse events reported
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