Lucentis(ranibizumab)
Byooviz, Cimerli, Lucentis, Ranivisio, Susvimo, Ximluci (ranibizumab) is an antibody pharmaceutical. Ranibizumab was first approved as Lucentis on 2006-06-30. It is used to treat diabetic retinopathy, macular edema, and retinal vein occlusion in the USA. It has been approved in Europe to treat choroidal neovascularization, degenerative myopia, diabetes complications, diabetic retinopathy, and macular edema amongst others. The pharmaceutical is active against vascular endothelial growth factor A, long form. In addition, it is known to target Vascular permeability factor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Byooviz, Cimerli, Lucentis, Susvimo (discontinued: Lucentis)
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| macular edema | — | D008269 | — |
| retinal vein occlusion | EFO_1001157 | D012170 | H34.81 |
| diabetic retinopathy | EFO_0003770 | D003930 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ranibizumab, Cimerli, Coherus BioSciences, Inc. | |||
| 10/3/2023 | Interchangeable excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2778 | Injection, ranibizumab, 0.1 mg |
Clinical
Clinical Trials
640 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 38 | 92 | 74 | 47 | 59 | 280 |
| Macular edema | D008269 | — | — | 22 | 54 | 41 | 39 | 37 | 176 |
| Choroidal neovascularization | D020256 | — | — | 12 | 27 | 22 | 12 | 11 | 75 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 12 | 15 | 18 | 19 | 17 | 74 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 7 | 23 | 15 | 14 | 13 | 65 |
| Retinal diseases | D012164 | — | H35.9 | 8 | 12 | 12 | 8 | 8 | 41 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | 6 | 14 | 11 | 9 | 8 | 40 |
| Edema | D004487 | — | R60.9 | 3 | 6 | 8 | 9 | 10 | 34 |
| Vision disorders | D014786 | — | H53.11 | — | 5 | 15 | 6 | 3 | 29 |
| Pathologic neovascularization | D009389 | — | — | 4 | 7 | 2 | 4 | 6 | 22 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal degeneration | D012162 | — | — | 3 | 5 | 4 | — | — | 9 |
| Glaucoma | D005901 | EFO_0000516 | H40 | 2 | 3 | 2 | — | 2 | 6 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | 3 | 2 | 1 | — | — | 5 |
| Degenerative myopia | D047728 | — | H44.2 | 2 | 2 | 2 | — | — | 5 |
| Pterygium | D011625 | — | H11.0 | 3 | 1 | 1 | — | — | 4 |
| Recurrence | D012008 | — | — | — | 1 | 1 | — | 1 | 2 |
| Melanoma | D008545 | — | — | 1 | 1 | 1 | — | — | 2 |
| Blindness | D001766 | — | H53.12 | — | 1 | 1 | — | — | 2 |
| Retinal hemorrhage | D012166 | — | H35.6 | 1 | 1 | 1 | — | — | 2 |
| Choroid diseases | D015862 | — | H31.9 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Telangiectasis | D013684 | — | — | 4 | 1 | — | — | — | 5 |
| Ischemia | D007511 | EFO_0000556 | — | 3 | 1 | — | — | 1 | 4 |
| Angioid streaks | D000793 | EFO_1000805 | — | 1 | 2 | — | — | 1 | 3 |
| Von hippel-lindau disease | D006623 | — | Q85.83 | 3 | 2 | — | — | — | 3 |
| Central serous chorioretinopathy | D056833 | — | H35.71 | 2 | 1 | — | — | — | 2 |
| Pseudoxanthoma elasticum | D011561 | Orphanet_758 | Q82.8 | 1 | 2 | — | — | — | 2 |
| Retinal telangiectasis | D058456 | Orphanet_190 | H35.02 | 1 | 1 | — | — | 1 | 2 |
| Histoplasmosis | D006660 | EFO_0007310 | B39 | 1 | 2 | — | — | — | 2 |
| Retinal dystrophies | D058499 | Orphanet_71862 | — | — | 1 | — | — | — | 1 |
| Diabetic angiopathies | D003925 | EFO_1000896 | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | 2 | 3 |
| Bites and stings | D001733 | — | — | 2 | — | — | — | — | 2 |
| Corneal neovascularization | D016510 | EFO_1000880 | H16.4 | 2 | — | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Hereditary hemorrhagic telangiectasia | D013683 | — | I78.0 | 1 | — | — | — | — | 1 |
| Epistaxis | D004844 | EFO_0003895 | R04.0 | 1 | — | — | — | — | 1 |
| Pathologic processes | D010335 | — | — | 1 | — | — | — | — | 1 |
| Depression | D003863 | — | F33.9 | 1 | — | — | — | — | 1 |
| Port-wine stain | D019339 | — | Q82.5 | 1 | — | — | — | — | 1 |
| Neurofibromatosis 1 | D009456 | — | Q85.01 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 2 | 2 |
| Chorioretinitis | D002825 | — | H30 | — | — | — | — | 1 | 1 |
| Refractive errors | D012030 | HP_0000483 | H52.7 | — | — | — | — | 1 | 1 |
| Intraocular pressure | D007429 | — | — | — | — | — | — | 1 | 1 |
| Regional blood flow | D012039 | — | — | — | — | — | — | 1 | 1 |
| Low vision | D015354 | — | — | — | — | — | — | 1 | 1 |
| Cataract extraction | D002387 | — | — | — | — | — | — | 1 | 1 |
| Premature infant diseases | D007235 | — | — | — | — | — | — | 1 | 1 |
| Laser coagulation | D017075 | — | — | — | — | — | — | 1 | 1 |
| Intravitreal injections | D058449 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ranibizumab |
| INN | ranibizumab |
| Description | Immunoglobulin G1, anti-(human vascular endothelial growth factor) Fab fragment (human-mouse monoclonal rhuFAB V2 gamma1-chain), disulfide with human-mouse monoclonal rhuFAB V2 kappa-chain |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >1CZ8:H,Y|HEAVY CHAIN OF NEUTRALIZING ANTIBODY
EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAY
LQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV
TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHL
>1CZ8:L,X|LIGHT CHAIN OF NEUTRALIZING ANTIBODY
DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 1CZ8 |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201825 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB01270 |
| UNII ID | ZL1R02VT79 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
VEGFA
VEGFA
Organism
Homo sapiens
Gene name
VEGFA
Gene synonyms
NCBI Gene ID
—
Protein name
Vascular endothelial growth factor A
Protein synonyms
Vascular permeability factor
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
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Lucentis – Novartis
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Lucentis – Roche
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Cimerli – Coherus Oncology
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Byooviz – Biogen
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
Black-box warning for: Susvimo
Adverse Events
Top Adverse Reactions
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29,948 adverse events reported
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