Cyramza(ramucirumab)
Cyramza (ramucirumab) is an antibody pharmaceutical. Ramucirumab was first approved as Cyramza on 2014-04-21. It is used to treat colorectal neoplasms, non-small-cell lung carcinoma, and stomach neoplasms in the USA. It has been approved in Europe to treat stomach neoplasms. The pharmaceutical is active against vascular endothelial growth factor receptor 2.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Cyramza
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cyramza | Biologic Licensing Application | 2025-12-18 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| colorectal neoplasms | — | D015179 | — |
| non-small-cell lung carcinoma | — | D002289 | — |
| stomach neoplasms | EFO_0003897 | D013274 | C16 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ramucirumab, Cyramza, Eli Lilly and Company | |||
| 2026-05-10 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9308 | Injection, ramucirumab, 5 mg |
Clinical
Clinical Trials
183 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 7 | 13 | 3 | — | — | 20 |
| Adenocarcinoma | D000230 | — | — | 4 | 8 | 5 | — | 1 | 16 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 3 | 6 | 3 | — | 2 | 13 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | 5 | 1 | — | — | 7 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 3 | 3 | 2 | — | — | 7 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | 2 | 2 | — | — | 6 |
| Colorectal neoplasms | D015179 | — | — | 2 | 1 | 2 | — | — | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 2 | 1 | — | — | 5 |
| Lung neoplasms | D008175 | — | C34.90 | — | 2 | 2 | — | — | 4 |
| Urethral neoplasms | D014523 | EFO_0003846 | — | 1 | 1 | 1 | — | — | 3 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 12 | 10 | — | — | — | 21 |
| Carcinoma | D002277 | — | C80.0 | 1 | 3 | — | — | — | 3 |
| Colonic neoplasms | D003110 | — | C18 | 1 | 2 | — | — | — | 3 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | 3 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 2 | — | — | — | 3 |
| Rectal neoplasms | D012004 | — | — | 1 | 1 | — | — | — | 2 |
| Sarcoma | D012509 | — | — | 2 | 2 | — | — | — | 2 |
| Ureteral neoplasms | D014516 | EFO_0003844 | C66 | 1 | 1 | — | — | — | 2 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 2 | — | — | — | 2 |
| Melanoma | D008545 | — | — | 1 | 1 | — | — | — | 2 |
Show 19 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Cutaneous malignant melanoma | D000096142 | — | — | 1 | — | — | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 1 | — | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | 1 | — | — | — | — | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | 1 | — | — | — | — | 1 |
| Digestive system neoplasms | D004067 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms by site | D009371 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ramucirumab |
| INN | ramucirumab |
| Description | Ramucirumab (human mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743062 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB05578 |
| UNII ID | D99YVK4L0X (ChemIDplus, GSRS) |
Target
Agency Approved
KDR
KDR
Organism
Homo sapiens
Gene name
KDR
Gene synonyms
FLK1, VEGFR2
NCBI Gene ID
Protein name
vascular endothelial growth factor receptor 2
Protein synonyms
CD309, Fetal liver kinase 1, fetal liver kinase-1, FLK-1, KDR, Kinase insert domain receptor, kinase insert domain receptor (a type III receptor tyrosine kinase), Protein-tyrosine kinase receptor flk-1, soluble VEGFR2, tyrosine kinase growth factor receptor
Uniprot ID
Mouse ortholog
Kdr (16542)
vascular endothelial growth factor receptor 2 (Q8VCD0)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Cyramza – Eli Lilly
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Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 9,460 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,389 adverse events reported
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