Raltitrexed
Raltitrexed is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against thymidylate synthase.
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83 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | — | 1 | 1 | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
| Rectal neoplasms | D012004 | — | — | — | 1 | — | — | — | 1 |
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Drug
General
| Drug common name | Raltitrexed |
| INN | raltitrexed |
| Description | Raltitrexed (Thaltitrexed, Tomudex, TDX, ZD 1694) is an antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca.
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| Classification | Small molecule |
| Drug class | antineoplastic thymidylate synthetase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)ccc2[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 112887-68-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL225071 |
| ChEBI ID | 5847 |
| PubChem CID | 104758 |
| DrugBank | DB00293 |
| UNII ID | FCB9EGG971 (ChemIDplus, GSRS) |
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478 adverse events reported
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