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AboutPricing
Drug ReportsPrednisone
Prednisone
Prednisone (prednisone) is a small molecule pharmaceutical. Prednisone was first approved as Paracort on 1982-01-01. It is used to treat adrenal insufficiency, allergic conjunctivitis, allergic rhinitis, ankylosing spondylitis, and asthma amongst others in the USA. The pharmaceutical is active against glucocorticoid receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
musculoskeletal diseasesD009140
digestive system diseasesD004066
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
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Trade Name
FDA
EMA
Prednisone (discontinued: Cortan, Deltasone, Deltome, Fernisone, Liquid pred, Meticorten, Orasone, Paracort, Prednicen, Prednisone, Rayos, Servisone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Prednisone
Tradename
Company
Number
Date
Products
RAYOSHorizon Therapeutics PublicN-202020 DISCN2012-07-26
3 products, RLD
PARACORTPfizerN-010962 DISCN1982-01-01
1 products
DELTASONEPharmacia & UpjohnN-009986 DISCN1982-01-01
5 products, RLD
PREDNISONERoxane LaboratoriesN-017109 DISCN1982-01-01
1 products
METICORTENMerck & CoN-009766 DISCN1982-01-01
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
cortane-bunapproved drug other2017-03-20
deltasoneANDA2018-11-02
deltasone 5mgANDA2020-10-15
p- pack prednisone 20mg, 7- day tapering dose packANDA2025-02-11
prednisoneANDA2025-02-07
prednisone prednisoneANDA2024-02-09
prednisone prednisone intensolANDA2024-02-20
prednisone tablets, usp, 10 mgANDA2025-02-12
prednisone tablets, usp, 10 mg prednisone tablets, usp, 20 mg prednisone tablets, usp, 5 mgANDA2024-03-06
prednisone tablets, usp, 20 mgANDA2025-02-12
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
leukemia—D007938C95
psoriatic arthritisEFO_0003778D015535L40.5
atopic dermatitisEFO_0000274D003876L20
ulcerative colitisEFO_0000729D003093K51
ankylosing spondylitisEFO_0003898D013167M45
nephrotic syndromeEFO_0004255D009404N04
multiple sclerosisEFO_0003885D009103G35
sarcoidosisEFO_0000690D012507D80-D89
lymphoma—D008223C85.9
graft vs host disease—D006086D89.81
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Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Prednisone, Rayos, Horizon
81682182028-01-07DPU-1269
95046992027-08-03U-1362
83091242024-04-23U-1292
83944072024-04-23DPU-1362
90400852024-04-23U-1362
91863322024-04-23U-1362
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07E: Intestinal antiinflammatory agents
— A07EA: Corticosteroids acting locally
— A07EA03: Prednisone
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H02: Corticosteroids for systemic use
— H02A: Corticosteroids for systemic use, plain
— H02AB: Glucocorticoids, systemic
— H02AB07: Prednisone
HCPCS
Code
Description
G2112
Patient receiving <=5 mg daily prednisone (or equivalent), or ra activity is worsening, or glucocorticoid use is for less than 6 months
G2113
Patient receiving >5 mg daily prednisone (or equivalent) for longer than 6 months, and improvement or no change in disease activity
G9468
Patient not receiving corticosteroids greater than or equal to 10 mg/day of prednisone equivalents for 60 or greater consecutive days or a single prescription equating to 600 mg prednisone or greater for all fills
G9470
Patients not receiving corticosteroids greater than or equal to 10 mg/day of prednisone equivalents for 60 or greater consecutive days or a single prescription equating to 600 mg prednisone or greater for all fills
J7512
Prednisone, immediate release or delayed release, oral, 1 mg
Clinical
Clinical Trials
2311 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CataractD002386EFO_0001059H26.9—11——2
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePrednisone
INNprednisone
Description
Prednisone is a synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. It has a role as a prodrug, an anti-inflammatory drug, an antineoplastic agent, an immunosuppressive agent and an adrenergic agent. It is a 20-oxo steroid, an 11-oxo steroid, a 21-hydroxy steroid, a 17alpha-hydroxy steroid, a glucocorticoid, a 3-oxo-Delta(1),Delta(4)-steroid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone and a C21-steroid.
Classification
Small molecule
Drug classprednisone and prednisolone derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO
Identifiers
PDB—
CAS-ID53-03-2
RxCUI—
ChEMBL IDCHEMBL635
ChEBI ID8382
PubChem CID5865
DrugBankDB00635
UNII IDVB0R961HZT (ChemIDplus, GSRS)
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
2908
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Q6N0A4
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Rayos – Horizon Therapeutics Public
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Estimated US medical usage
Prednisone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 14,467 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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174,187 adverse events reported
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