Pralidoxime
Duodote, Protopam (pralidoxime) is a small molecule pharmaceutical. Pralidoxime was first approved as Protopam chloride on 1982-01-01. It is used to treat drug overdose and poisoning in the USA. The pharmaceutical is active against acetylcholinesterase.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| chemically-induced disorders | D064419 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Protopam (discontinued: Pralidoxime, Protopam)
CombinationsDuodote (discontinued: Atnaa)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pralidoxime chloride
Atropine
+
Pralidoxime chloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUODOTE | Meridian Medical Technologies | N-021983 RX | 2006-09-28 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atnaa | 2007-05-17 | |
| atnaa atropine and pralidoxime chloride | New Drug Application | 2022-07-18 |
| duodote | New Drug Application | 2022-04-04 |
| protopam chloride | New Drug Application | 2018-01-01 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2730 | Injection, pralidoxime chloride, up to 1 gm |
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Poisoning | D011041 | EFO_0008546 | T65.91 | 1 | 1 | 1 | — | 2 | 5 |
| Organophosphate poisoning | D062025 | — | — | 1 | 1 | 1 | — | 1 | 4 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Death | D003643 | PATO_0001422 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pralidoxime |
| INN | — |
| Description | Pralidoxime is a pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2. It has a role as a cholinergic drug, a cholinesterase reactivator, an antidote to organophosphate poisoning and an antidote to sarin poisoning. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[n+]1ccccc1C=NO |
Identifiers
| PDB | — |
| CAS-ID | 6735-59-7 |
| RxCUI | 1546365 |
| ChEMBL ID | CHEMBL1420 |
| ChEBI ID | 8354 |
| PubChem CID | 135398747 |
| DrugBank | DB00733 |
| UNII ID | — |
Target
Agency Approved
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,158 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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22 adverse events reported
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