Pralidoxime
Duodote, Protopam (pralidoxime) is a small molecule pharmaceutical. Pralidoxime was first approved as Protopam chloride on 1982-01-01. It is used to treat drug overdose and poisoning in the USA. The pharmaceutical is active against acetylcholinesterase.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| chemically-induced disorders | D064419 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Protopam (discontinued: Pralidoxime, Protopam)
CombinationsDuodote (discontinued: Atnaa)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pralidoxime chloride
Atropine
+
Pralidoxime chloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUODOTE | Meridian Medical Technologies | N-021983 RX | 2006-09-28 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| antibacterial | OTC monograph not final | 2010-08-24 |
| antibacterial hand sanitizer | OTC monograph not final | 2010-10-08 |
| atnaa | 2007-05-17 | |
| atnaa atropine and pralidoxime chloride | New Drug Application | 2022-07-18 |
| backaid | C200263 | 2025-04-14 |
| caso candiq. plus | unapproved drug other | 2017-07-19 |
| caso hair vita | unapproved drug other | 2017-07-19 |
| caso skin vita | unapproved drug other | 2017-07-19 |
| cramp tabs | C200263 | 2024-10-04 |
| cvs pinworm treatment | C200263 | 2024-12-18 |
Show 45 more
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2730 | Injection, pralidoxime chloride, up to 1 gm |
Clinical
Clinical Trials
191 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | 1 | 2 |
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 14 | 25 | 4 | — | 2 | 39 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 11 | 14 | 1 | — | 2 | 26 |
| Myelodysplastic syndromes | D009190 | — | D46 | 10 | 14 | 1 | — | 1 | 24 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 8 | 12 | 1 | — | 3 | 23 |
| Lymphoma | D008223 | — | C85.9 | 4 | 7 | 1 | — | 3 | 14 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 6 | 4 | 3 | — | 1 | 14 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 9 | 1 | — | 1 | 13 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 5 | 6 | 1 | — | 3 | 13 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 5 | 1 | — | 2 | 9 |
| Melanoma | D008545 | — | — | 3 | 2 | 1 | — | 3 | 8 |
Show 12 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 13 | 19 | — | — | 3 | 28 |
| Hodgkin disease | D006689 | — | C81 | 8 | 10 | — | — | 3 | 18 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 6 | 6 | — | — | 1 | 13 |
| Leukemia | D007938 | — | C95 | 4 | 8 | — | — | 2 | 13 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 5 | 8 | — | — | 3 | 12 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 4 | 7 | — | — | 3 | 12 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 3 | 8 | — | — | 1 | 10 |
| Follicular lymphoma | D008224 | — | C82 | 3 | 7 | — | — | 3 | 10 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 2 | 7 | — | — | 1 | 10 |
| Primary myelofibrosis | D055728 | — | D47.4 | 3 | 6 | — | — | 1 | 10 |
Show 107 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ewing sarcoma | D012512 | EFO_0000173 | — | 3 | — | — | — | 2 | 5 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | 3 | 4 |
| Myeloid leukemia | D007951 | — | C92 | 2 | — | — | — | 1 | 3 |
| Lymphoid leukemia | D007945 | — | C91 | 2 | — | — | — | 1 | 3 |
| Poisoning | D011041 | EFO_0008546 | T65.91 | 1 | — | — | — | 2 | 3 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 1 | 3 |
| Rhabdoid tumor | D018335 | — | — | 2 | — | — | — | — | 2 |
| Ependymoma | D004806 | — | — | 2 | — | — | — | — | 2 |
| Preleukemia | D011289 | — | — | 2 | — | — | — | — | 2 |
| Wilms tumor | D009396 | EFO_0000212 | — | 2 | — | — | — | — | 2 |
Show 20 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 3 | 3 |
| Intraocular lymphoma | D064090 | — | — | — | — | — | — | 2 | 2 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 2 | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 2 | 2 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | — | — | 2 | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 2 | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 2 | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 2 | 2 |
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 2 | 2 |
| Shock | D012769 | — | R57.1 | — | — | — | — | 2 | 2 |
Show 64 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pralidoxime |
| INN | — |
| Description | Pralidoxime is a pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2. It has a role as a cholinergic drug, a cholinesterase reactivator, an antidote to organophosphate poisoning and an antidote to sarin poisoning. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[n+]1ccccc1C=NO |
Identifiers
| PDB | — |
| CAS-ID | 6735-59-7 |
| RxCUI | 1546365 |
| ChEMBL ID | CHEMBL1420 |
| ChEBI ID | 8354 |
| PubChem CID | 135398747 |
| DrugBank | DB00733 |
| UNII ID | — |
Target
Agency Approved
Alternate
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Variants
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Zyprexa – Eli Lilly
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Trends
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Additional graphs summarizing 69,714 documents
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Safety
Black-box Warning
Black-box warning for: Imipramine pamoate, Pamelor, Zyprexa
Adverse Events
Top Adverse Reactions
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222,357 adverse events reported
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