Mozobil(plerixafor)
Mozobil, Plerixafor (plerixafor) is a small molecule pharmaceutical. Plerixafor was first approved as Mozobil on 2008-12-15. It is used to treat multiple myeloma and non-hodgkin lymphoma in the USA. It has been approved in Europe to treat hematopoietic stem cell transplantation, lymphoma, and multiple myeloma. The pharmaceutical is active against C-X-C chemokine receptor type 4. In addition, it is known to target atypical chemokine receptor 3.
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Commercial
Trade Name
FDA
EMA
Mozobil, Plerixafor (discontinued: Plerixafor)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| mozobil | New Drug Application | 2023-10-05 |
| plerixafor | ANDA | 2024-12-06 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| non-hodgkin lymphoma | — | D008228 | C85.9 |
| multiple myeloma | — | D009101 | C90.0 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2562 | Injection, plerixafor, 1 mg |
Clinical
Clinical Trials
180 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 1 | 12 | 2 | 1 | 6 | 21 |
| Lymphoma | D008223 | — | C85.9 | 1 | 11 | 3 | 1 | 5 | 21 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 10 | 3 | 1 | 3 | 18 |
| Autologous transplantation | D014182 | — | — | — | 1 | — | 1 | 3 | 5 |
| Hematopoietic stem cell transplantation | D018380 | — | — | — | 1 | — | 1 | 1 | 3 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasma cell neoplasms | D054219 | — | — | 1 | 10 | 2 | — | 5 | 17 |
| Hodgkin disease | D006689 | — | C81 | — | 5 | 1 | — | 1 | 7 |
| Transplantation | D014180 | — | — | 1 | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 10 | 4 | — | — | 1 | 12 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 7 | 3 | — | — | — | 8 |
| Myeloid leukemia | D007951 | — | C92 | 7 | 3 | — | — | — | 8 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 2 | — | — | 1 | 4 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | 1 | — | — | — | 3 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | — | — | — | 2 |
| Glioma | D005910 | EFO_0000520 | — | 1 | 1 | — | — | — | 2 |
| Gliosarcoma | D018316 | — | — | 1 | 1 | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoid leukemia | D007945 | — | C91 | 3 | — | — | — | — | 3 |
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | — | — | — | — | 1 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 1 | — | — | — | — | 1 |
| Diabetic foot | D017719 | EFO_1001459 | — | 1 | — | — | — | — | 1 |
| Ulcer | D014456 | MPATH_579 | — | 1 | — | — | — | — | 1 |
| Foot ulcer | D016523 | — | — | 1 | — | — | — | — | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Serous cystadenocarcinoma | D018284 | — | — | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | — | — | — | — | 1 | 1 |
| Paraproteinemias | D010265 | — | D47.2 | — | — | — | — | 1 | 1 |
| Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | — | — | — | — | 1 | 1 |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | — | — | — | — | 1 | 1 |
| Myeloid leukemia chronic-phase | D015466 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Plerixafor |
| INN | plerixafor |
| Description | Plerixafor is an azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma. It has a role as an immunological adjuvant, an antineoplastic agent, an anti-HIV agent and a C-X-C chemokine receptor type 4 antagonist. It is an azamacrocycle, a crown amine, a secondary amino compound, an azacycloalkane, a tertiary amino compound and a member of benzenes. It is functionally related to a 1,4,8,11-tetraazacyclotetradecane. |
| Classification | Small molecule |
| Drug class | CXCR receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | c1cc(CN2CCCNCCNCCCNCC2)ccc1CN1CCCNCCNCCCNCC1 |
Identifiers
| PDB | — |
| CAS-ID | 110078-46-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL18442 |
| ChEBI ID | — |
| PubChem CID | 65015 |
| DrugBank | DB06809 |
| UNII ID | S915P5499N (ChemIDplus, GSRS) |
Target
Agency Approved
CXCR4
CXCR4
Organism
Homo sapiens
Gene name
CXCR4
Gene synonyms
NCBI Gene ID
Protein name
C-X-C chemokine receptor type 4
Protein synonyms
CD184, CD184 antigen, chemokine (C-X-C motif) receptor 4, FB22, Fusin, HM89, LAP-3, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, Lipopolysaccharide-associated protein 3, LPS-associated protein 3, neuropeptide Y receptor Y3, neuropeptide Y3 receptor, NPYRL, SDF-1 receptor, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor
Uniprot ID
Mouse ortholog
Cxcr4 (12767)
C-X-C chemokine receptor type 4 (Q4KMW1)
Alternate
ACKR3
ACKR3
Organism
Homo sapiens
Gene name
ACKR3
Gene synonyms
CMKOR1, CXCR7, GPR159, RDC1
NCBI Gene ID
Protein name
atypical chemokine receptor 3
Protein synonyms
C-X-C chemokine receptor type 7, chemokine (C-X-C motif) receptor 7, Chemokine orphan receptor 1, CXC-R7, CXCR-7, G protein-coupled receptor, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, RDC-1
Uniprot ID
Mouse ortholog
Ackr3 (12778)
atypical chemokine receptor 3 (Q91WI0)
Variants
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Financial
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Trends
PubMed Central
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Safety
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No Black-box warning
Adverse Events
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993 adverse events reported
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