Jaypirca(pirtobrutinib)
Jaypirca (pirtobrutinib) is a small molecule pharmaceutical. Pirtobrutinib was first approved as Jaypirca on 2023-01-27. It is used to treat mantle-cell lymphoma in the USA. It has been approved in Europe to treat mantle-cell lymphoma. It is known to target tyrosine-protein kinase BTK.
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Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Jaypirca
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pirtobrutinib
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| JAYPIRCA | Loxo Oncology | N-216059 RX | 2023-01-27 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| jaypirca | New Drug Application | 2025-12-04 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| mantle-cell lymphoma | — | D020522 | C83.1 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
PIRTOBRUTINIB, JAYPIRCA, LOXO ONCOL | |||
| 2030-01-27 | ODE-424 | ||
| 2028-01-27 | NCE | ||
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
64 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 6 | 14 | 7 | 3 | 2 | 28 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 4 | 5 | 3 | 2 | — | 13 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mantle-cell lymphoma | D020522 | — | C83.1 | 4 | 10 | 1 | — | 2 | 16 |
| Lymphoma | D008223 | — | C85.9 | 3 | 5 | 2 | — | 1 | 10 |
| Lymphoid leukemia | D007945 | — | C91 | 1 | 4 | 2 | — | 1 | 8 |
| B-cell lymphoma | D016393 | — | — | 3 | 3 | 3 | — | — | 8 |
| Leukemia | D007938 | — | C95 | 2 | 5 | 1 | — | — | 7 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | 3 | — | — | 3 |
| Reactive arthritis | D016918 | EFO_0007460 | M02.3 | 1 | 1 | 1 | — | — | 2 |
| B-cell leukemia | D015448 | — | — | — | — | 2 | — | — | 2 |
| Recurrence | D012008 | — | — | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 4 | 4 | — | — | — | 7 |
| Waldenstrom macroglobulinemia | D008258 | — | C88.0 | 3 | 3 | — | — | 2 | 7 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 4 | — | — | — | 5 |
| Follicular lymphoma | D008224 | — | C82 | 3 | 2 | — | — | — | 4 |
| Interdigitating dendritic cell sarcoma | D054739 | — | C96.4 | 1 | 2 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Hairy cell leukemia | D007943 | — | C91.4 | — | 1 | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | — | 1 | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | — | — | — | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 14 | — | — | — | — | 14 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
| Syndrome | D013577 | — | — | 1 | — | — | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | — | — | — | — | 1 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
| Liver failure | D017093 | — | K72.9 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 1 | 1 |
| Sudden death cardiac | D016757 | EFO_0004278 | — | — | — | — | — | 1 | 1 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | — | — | 1 | 1 |
| Supraventricular tachycardia | D013617 | — | I47.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pirtobrutinib |
| INN | pirtobrutinib |
| Description | Pirtobrutinib, sold under the brand name Jaypirca, is an anticancer medication that is used to treat mantle cell lymphoma. It inhibits B cell lymphocyte proliferation and survival by binding and inhibiting Bruton's tyrosine kinase (BTK). It is taken by mouth.
|
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors: tyrosine kinase inhibitors Bruton's (Btk) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(F)cc1C(=O)NCc1ccc(-c2nn([C@@H](C)C(F)(F)F)c(N)c2C(N)=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 2101700-15-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4650485 |
| ChEBI ID | — |
| PubChem CID | 129269915 |
| DrugBank | DB17472 |
| UNII ID | JNA39I7ZVB (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
BTK
BTK
Organism
Homo sapiens
Gene name
BTK
Gene synonyms
AGMX1, ATK, BPK
NCBI Gene ID
Protein name
tyrosine-protein kinase BTK
Protein synonyms
agammaglobulinaemia tyrosine kinase, Agammaglobulinemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, Bruton's tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase
Uniprot ID
Mouse ortholog
Btk (12229)
tyrosine-protein kinase BTK (Q61365)
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 599 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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470 adverse events reported
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