Loxo Oncology - PharmaKB

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Disease Reports

Company ReportsLoxo Oncology

Loxo Oncology(LOXO)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Jaypirca	Pirtobrutinib	2023-01-27	2036	Mantle-cell lymphoma

Clinical Trials

Therapeutic Areas:

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Classification:

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Approval:

All

Status:

All

Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

healthy volunteers/patients

,

renal insufficiency

,

,

hepatic insufficiency

,

b-cell lymphoma marginal zone

,

waldenstrom macroglobulinemia

,

b-cell lymphoma

,

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

,

,

mantle-cell lymphoma

,

b-cell leukemia

prostatic neoplasms

,

carcinoma in situ

,

cervical intraepithelial neoplasia

,

uterine cervical dysplasia

,

,

b-cell chronic lymphocytic leukemia

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

b-cell lymphoma

,

lymphoid leukemia

,

ischemic stroke

,

,

patent foramen ovale

,

atrial fibrillation

alzheimer disease

,

myelodysplastic syndromes

,

,

hepatic insufficiency

,

cognitive dysfunction

,

precursor cell lymphoblastic leukemia-lymphoma

,

maximum tolerated dose

,

antineoplastic protocols

,

pharmacokinetics

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

,

aplastic anemia

,

paraproteinemias

,

monoclonal gammopathy of undetermined significance

,

,

laboratory infection

,

myeloid leukemia acute

,

castration-resistant prostatic neoplasms

,

myeloid leukemia

,

,

,

acquired immunodeficiency syndrome

,

hematologic neoplasms

,

,

immunologic deficiency syndromes

,

,

hypergammaglobulinemia

,

,

chronic hepatitis b

,

,

,

prostatic neoplasms

,

neoplasm metastasis

,

multiple myeloma

,

plasma cell neoplasms

,

colorectal neoplasms

,

colonic neoplasms

,

colonic diseases

,

,

sexually transmitted diseases

,

retroviridae infections

,

viral sexually transmitted diseases

,

b-cell lymphoma marginal zone

,

burkitt lymphoma

,

,

pulmonary tuberculosis

,

healthy volunteers/patients

,

non-small-cell lung carcinoma

,

b-cell lymphoma

,

large b-cell lymphoma diffuse

,

non-hodgkin lymphoma

,

follicular lymphoma

,

,

graft vs host disease

,

bronchiolitis obliterans syndrome

,

renal insufficiency

,

respiratory syncytial viruses

,

,

ebola hemorrhagic fever

,

cerebrospinal fluid leak

,

,

soft tissue injuries

,

respiratory tract diseases

,

kidney transplantation

,

prolymphocytic leukemia t-cell

,

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

atrial fibrillation

,

papulosquamous skin diseases

Polyglycolic acid

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

,

invasive candidiasis

,

,

,

,

,

invasive fungal infections

,

communicable diseases

,

pneumocystis pneumonia

,

,

,

invasive hydatidiform mole

Globulin, immune

thoracic neoplasms

,

,

small cell carcinoma

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

endocrine gland neoplasms

,

glandular and epithelial neoplasms

,

breast diseases

,

bronchial neoplasms

,

,

colorectal neoplasms

,

pancreatic neoplasms

,

,

renal cell carcinoma

,

ovarian neoplasms

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

,

urinary bladder neoplasms

,

ovarian epithelial carcinoma

,

neoplasm metastasis

,

liver neoplasms

,

follicular lymphoma

,

,

squamous cell neoplasms

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

uterine cervical neoplasms

,

non-hodgkin lymphoma

,

esophageal neoplasms

,

urologic neoplasms

,

prostatic neoplasms

,

pancreatic ductal carcinoma

,

lymphoid leukemia

,

transitional cell carcinoma

,

esophageal squamous cell carcinoma

,

hodgkin disease

,

cholangiocarcinoma

,

stomach neoplasms

,

castration-resistant prostatic neoplasms

,

kidney neoplasms

,

,

colonic neoplasms

,

kidney diseases

,

uterine neoplasms

,

urethral neoplasms

,

ureteral neoplasms

,

pelvic neoplasms

,

brain neoplasms

,

,

neoplasms by histologic type

,

adenoviridae infections

,

serous cystadenocarcinoma

,

endometrioid carcinoma

,

,

hepatocellular carcinoma

,

,

invasive hydatidiform mole

,

cutaneous malignant melanoma

,

histiocytic sarcoma

,

follicular dendritic cell sarcoma

,

interdigitating dendritic cell sarcoma

,

hemangiosarcoma

,

chronic kidney failure

,

renal insufficiency

,

,

mullerian mixed tumor

,

,

nervous system diseases

,

nerve tissue neoplasms

,

primitive neuroectodermal tumors

,

neuroepithelial neoplasms

,

neuroectodermal tumors

,

bile duct neoplasms

,

,

clear cell adenocarcinoma

,

acinar cell carcinoma

,

,

sezary syndrome

,

mycosis fungoides

,

t-cell lymphoma cutaneous

,

,

b-cell chronic lymphocytic leukemia

,

non-muscle invasive bladder neoplasms

,

unknown primary neoplasms

,

immunoblastic lymphadenopathy

,

enteropathy-associated t-cell lymphoma

,

intestinal diseases

,

,

merkel cell carcinoma

,

mouth neoplasms

,

oropharyngeal neoplasms

,

nasopharyngeal neoplasms

,

laryngeal neoplasms

,

hypopharyngeal neoplasms

,

,

malignant fibrous histiocytoma

,

neuroendocrine tumors

,

microsatellite repeats

,

,

multiple myeloma

,

plasma cell neoplasms

,

rectal neoplasms

,

hypersensitivity

,

gastrointestinal stromal tumors

,

biliary tract neoplasms

,

male breast neoplasms

,

adenosquamous carcinoma

,

uveal neoplasms

,

non-small-cell lung carcinoma

,

,

,

,

squamous cell carcinoma of head and neck

,

breast neoplasms

,

head and neck neoplasms

,

squamous cell carcinoma

,

triple negative breast neoplasms

,

,

endometrial neoplasms

,

fallopian tube neoplasms

,

small cell lung carcinoma

,

clostridium infections

,

,

,

,

malignant mesothelioma

,

,

juvenile arthritis

,

,

,

,

,

,

,

rheumatoid arthritis

,

communicable diseases

,

ulcerative colitis

,

,

,

,

papillomavirus infections

,

immunologic deficiency syndromes

,

,

pneumococcal infections

,

prostatic intraepithelial neoplasia

,

carcinoma in situ

,

,

acquired immunodeficiency syndrome

,

uterine cervical dysplasia

,

,

,

coronavirus infections

,

human influenza

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

human papillomavirus recombinant vaccine quadrivalent types 6 11 16 18

,

agammaglobulinemia

,

common variable immunodeficiency

,

papillomaviridae

,

chronic renal insufficiency

,

flavivirus infections

,

,

,

,

,

prediabetic state

,

hypercholesterolemia

,

cerebrovascular disorders

,

diabetes mellitus

,

coronary artery disease

,

peripheral arterial disease

,

,

healthy volunteers/patients

thyroid neoplasms

,

papillary thyroid cancer

,

thyroid diseases

,

,

,

myofibromatosis

,

,

non-small-cell lung carcinoma

,

,

colonic neoplasms

,

neuroendocrine carcinoma

,

,

healthy volunteers/patients

,

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

hematologic neoplasms

,

myeloproliferative disorders

,

myelomonocytic leukemia chronic

,

myeloid leukemia

,

myelomonocytic leukemia juvenile

,

,

,

cholangiocarcinoma

,

Antineoplaston a10

multiple myeloma

,

plasma cell neoplasms

,

,

communicable diseases

,

bacterial infections

,

methicillin-resistant staphylococcus aureus

,

staphylococcal skin infections

,

infectious skin diseases

,

bacterial skin diseases

,

,

healthy volunteers/patients

,

drug interactions

,

,

mitochondrial diseases

,

,

hypersensitivity

,

parkinson disease

,

,

ovarian neoplasms

,

ovarian epithelial carcinoma

,

prostatic neoplasms

,

gastrointestinal stromal tumors

,

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

,

rheumatoid arthritis

,

,

sickle cell anemia

,

,

,

renal insufficiency

,

,

,

cystic fibrosis

,

,

cardiovascular diseases

,

chronic renal insufficiency

,

kidney diseases

,

hypercholesterolemia

,

coronary disease

,

atherosclerosis

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

,

diabetes complications

,

,

,

bariatric surgery

,

,

pancreatic neoplasms

,

type 1 diabetes mellitus

,

prediabetic state

,

glucose intolerance

,

exocrine pancreatic insufficiency

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