Loxo Oncology - PharmaKB

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Disease Reports

Company ReportsLoxo Oncology

Loxo Oncology(LOXO)

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Therapeutic Areas:

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Jaypirca	Pirtobrutinib	2023-01-27	2036	Mantle-cell lymphoma

Clinical Trials

Therapeutic Areas:

All

Classification:

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Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

healthy volunteers/patients

,

psoriatic arthritis

,

,

cystic fibrosis

pharmacokinetics

gastroesophageal reflux

,

peptic esophagitis

,

atrial fibrillation

sjogren's syndrome

,

,

healthy volunteers/patients

,

factor vii deficiency

,

,

hidradenitis suppurativa

,

diffuse scleroderma

,

,

systemic scleroderma

,

rheumatoid arthritis

,

chronic obstructive pulmonary disease

,

soft tissue infections

,

necrotizing fasciitis

,

fournier gangrene

,

,

raynaud disease

,

wounds and injuries

,

myasthenia gravis

,

cardiac surgical procedures

,

,

eosinophilic esophagitis

,

postpartum hemorrhage

,

acute kidney injury

,

sickle cell anemia

,

acute chest syndrome

,

vaso-occlusive crises

,

,

agammaglobulinemia

,

common variable immunodeficiency

,

graft vs host disease

,

hereditary angioedemas

,

afibrinogenemia

,

blood coagulation disorders

,

ischemic stroke

,

,

coronary artery disease

,

,

heart valve diseases

,

chronic inflammatory demyelinating polyradiculoneuropathy

,

kidney transplantation

,

,

von willebrand diseases

,

hemostatic disorders

,

postoperative hemorrhage

,

dermatomyositis

,

atrial fibrillation

,

,

,

cardiovascular diseases

,

acute coronary syndrome

,

hemorrhagic stroke

,

peripheral arterial disease

,

atherosclerosis

,

central nervous system diseases

,

central nervous system infections

,

encephalomyelitis

,

,

meningoencephalitis

,

acquired immunodeficiency syndrome

,

,

factor xiii deficiency

,

thrombocytopenia

,

,

primary immunodeficiency diseases

,

,

hereditary angioedema types i and ii

,

alpha 1-antitrypsin deficiency

,

surgical blood loss

,

immunologic deficiency syndromes

,

thrombocytopenic purpura idiopathic

,

,

cardiovascular surgical procedures

,

tropical spastic paraparesis

,

,

communicable diseases

,

thromboembolism

,

,

,

pneumococcal infections

,

,

streptococcal infections

,

bacterial pneumonia

,

,

bacterial meningitis

,

haemophilus influenzae

,

hereditary complement deficiency diseases

,

neisseriaceae infections

,

,

,

ataxia telangiectasia

,

,

x-linked combined immunodeficiency diseases

,

cerebellar ataxia

colonic neoplasms

,

rectal neoplasms

,

non-small-cell lung carcinoma

,

,

,

colorectal neoplasms

,

healthy volunteers/patients

,

non-small-cell lung carcinoma

,

,

neoplasm metastasis

,

thyroid diseases

,

laryngeal diseases

,

prostatic neoplasms

,

head and neck neoplasms

,

postmenopausal osteoporosis

,

,

rheumatoid arthritis

,

metabolic bone diseases

Globulin, immune

squamous cell carcinoma of head and neck

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

neoadjuvant therapy

,

stomach neoplasms

,

,

,

large b-cell lymphoma diffuse

,

pancreatic ductal carcinoma

,

,

hepatocellular carcinoma

,

liver neoplasms

,

uterine cervical neoplasms

,

b-cell lymphoma

,

waldenstrom macroglobulinemia

,

,

squamous cell carcinoma

,

breast neoplasms

,

renal cell carcinoma

,

urologic neoplasms

,

,

transitional cell carcinoma

,

paraproteinemias

,

polyneuropathies

,

monoclonal gammopathy of undetermined significance

,

biliary tract neoplasms

,

gallbladder neoplasms

,

small cell lung carcinoma

,

,

non-small-cell lung carcinoma

,

,

b-cell chronic lymphocytic leukemia

,

follicular lymphoma

,

colorectal neoplasms

,

mantle-cell lymphoma

,

esophageal squamous cell carcinoma

,

b-cell lymphoma marginal zone

,

pancreatic neoplasms

,

neoplasm metastasis

,

non-hodgkin lymphoma

,

healthy volunteers/patients

,

rheumatoid arthritis

,

,

type 2 diabetes mellitus

,

drug interactions

healthy volunteers/patients

,

myelodysplastic syndromes

,

lymphoid leukemia

,

thoracic neoplasms

,

neurologic manifestations

,

papillomaviridae

,

pharmacokinetics

,

soft tissue neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

endocrine gland neoplasms

,

breast diseases

,

bronchial neoplasms

,

intraductal carcinoma noninfiltrating

,

laryngeal diseases

,

,

oligodendroglioma

,

oral administration

,

,

pancreatic neoplasms

,

,

brain neoplasms

,

castration-resistant prostatic neoplasms

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

non-hodgkin lymphoma

,

myeloid leukemia acute

,

t-cell lymphoma

,

follicular lymphoma

,

,

kidney neoplasms

,

neuroendocrine tumors

,

pancreatic ductal carcinoma

,

uveal neoplasms

,

,

invasive hydatidiform mole

,

neuroendocrine carcinoma

,

t-cell lymphoma peripheral

,

,

microsatellite instability

,

thyroid neoplasms

,

myeloid leukemia

,

urethral neoplasms

,

colonic neoplasms

,

uterine neoplasms

,

gastrointestinal neoplasms

,

mouth neoplasms

,

oropharyngeal neoplasms

,

small cell carcinoma

,

vulvar neoplasms

,

b-cell lymphoma marginal zone

,

,

female genital neoplasms

,

hypersensitivity

,

,

epstein-barr virus infections

,

microsatellite repeats

,

rectal neoplasms

,

hypopharyngeal neoplasms

,

salivary gland neoplasms

,

endometrioid carcinoma

,

serous cystadenocarcinoma

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

non-muscle invasive bladder neoplasms

,

penile neoplasms

,

neoplasms by histologic type

,

,

b-cell chronic lymphocytic leukemia

,

t-cell lymphoma cutaneous

,

ureteral neoplasms

,

,

,

,

thymus neoplasms

,

burkitt lymphoma

,

laryngeal neoplasms

,

,

adenoid cystic carcinoma

,

,

glandular and epithelial neoplasms

,

male breast neoplasms

,

,

adenocarcinoma of lung

,

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

mycosis fungoides

,

,

pelvic neoplasms

,

central nervous system neoplasms

,

germ cell and embryonal neoplasms

,

digestive system neoplasms

,

basal cell carcinoma

,

thyroid diseases

,

reactive arthritis

,

mullerian mixed tumor

,

,

adenosquamous carcinoma

,

gestational trophoblastic disease

,

alveolar soft part sarcoma

,

biphenotypic leukemia acute

,

local neoplasm recurrence

,

,

,

meningeal carcinomatosis

,

immunoblastic lymphadenopathy

,

enteropathy-associated t-cell lymphoma

,

,

carcinoma in situ

,

cervical intraepithelial neoplasia

,

uterine cervical dysplasia

,

squamous intraepithelial lesions of the cervix

,

disease progression

,

central nervous system diseases

,

extranodal nk-t-cell lymphoma

,

neoplasms by site

,

x-linked bulbo-spinal atrophy

,

malignant fibrous histiocytoma

,

nasopharyngeal carcinoma

,

,

,

unknown primary neoplasms

,

synovial sarcoma

,

,

oral leukoplakia

,

,

hematologic diseases

,

bone marrow diseases

,

,

sezary syndrome

,

,

colonic diseases

,

histiocytic sarcoma

,

follicular dendritic cell sarcoma

,

interdigitating dendritic cell sarcoma

,

environmental biomarkers

,

circulating neoplastic cells

,

inflammatory breast neoplasms

,

meningeal neoplasms

,

intestinal neoplasms

,

nervous system neoplasms

,

kidney diseases

,

nervous system diseases

,

nerve tissue neoplasms

,

neuroepithelial neoplasms

,

neuroectodermal tumors

,

anaplastic thyroid carcinoma

,

adrenocortical carcinoma

,

carcinoid tumor

,

parotid neoplasms

,

mediastinal neoplasms

,

testicular neoplasms

,

male genital neoplasms

,

gastrointestinal stromal tumors

,

hairy cell leukemia

,

vaginal neoplasms

,

spinal cord neoplasms

,

acinar cell carcinoma

,

adenoviridae infections

,

,

hereditary breast and ovarian cancer syndrome

,

basal cell neoplasms

,

urogenital neoplasms

,

male urogenital diseases

,

hemangiosarcoma

,

perivascular epithelioid cell neoplasms

,

,

,

,

breast neoplasms

,

colorectal neoplasms

,

triple negative breast neoplasms

,

squamous cell carcinoma

,

renal cell carcinoma

,

ovarian neoplasms

,

neoplasm metastasis

,

stomach neoplasms

,

head and neck neoplasms

,

urinary bladder neoplasms

,

,

,

prostatic neoplasms

,

liver neoplasms

,

hepatocellular carcinoma

,

esophageal neoplasms

,

endometrial neoplasms

,

uterine cervical neoplasms

,

small cell lung carcinoma

,

hodgkin disease

,

transitional cell carcinoma

,

urologic neoplasms

,

fallopian tube neoplasms

,

,

multiple myeloma

,

squamous cell neoplasms

,

ovarian epithelial carcinoma

,

,

biliary tract neoplasms

,

esophageal squamous cell carcinoma

,

cholangiocarcinoma

,

plasma cell neoplasms

,

,

malignant mesothelioma

,

peritoneal neoplasms

,

merkel cell carcinoma

,

cutaneous malignant melanoma

,

nasopharyngeal neoplasms

,

bile duct neoplasms

,

gallbladder neoplasms

,

hematologic neoplasms

,

non-small-cell lung carcinoma

,

,

squamous cell carcinoma of head and neck

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