Loxo Oncology - PharmaKB

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Disease Reports

Company ReportsLoxo Oncology

Loxo Oncology(LOXO)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Retevmo	Selpercatinib	2020-05-08	2037-2038	Non-small-cell lung carcinoma , Thyroid neoplasms
Jaypirca	Pirtobrutinib	2023-01-27	2036	Mantle-cell lymphoma

Clinical Trials

Therapeutic Areas:

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Classification:

All

Approval:

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Status:

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Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

healthy volunteers/patients

,

renal insufficiency

,

hepatic insufficiency

,

,

,

,

breast neoplasms

,

,

non-hodgkin lymphoma

,

,

,

,

,

germ cell and embryonal neoplasms

,

medulloblastoma

,

,

,

,

rhabdomyosarcoma

,

primitive neuroectodermal tumors

,

primitive neuroectodermal tumors peripheral

,

,

,

,

langerhans-cell histiocytosis

,

neuroectodermal tumors

,

colonic neoplasms

,

gastrointestinal neoplasms

,

central nervous system neoplasms

,

nervous system neoplasms

,

histiocytic sarcoma

,

juvenile xanthogranuloma

,

squamous cell carcinoma

,

anaplastic thyroid carcinoma

,

medullary carcinoma

,

papillary carcinoma

,

brain stem neoplasms

,

,

myofibromatosis

,

follicular adenocarcinoma

,

non-small-cell lung carcinoma

,

papillary thyroid cancer

,

,

neuroendocrine carcinoma

,

thyroid neoplasms

,

thyroid diseases

,

pancreatic neoplasms

,

erectile dysfunction

,

,

,

physiological sexual dysfunction

ischemic stroke

,

,

patent foramen ovale

,

atrial fibrillation

,

thromboembolism

respiratory insufficiency

,

hepatocellular carcinoma

,

liver neoplasms

,

atrial fibrillation

,

,

allergic rhinitis seasonal

,

allergic rhinitis perennial

,

,

,

allergic rhinitis

,

,

b-cell chronic lymphocytic leukemia

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

b-cell lymphoma

,

lymphoid leukemia

,

ischemic stroke

,

,

patent foramen ovale

,

atrial fibrillation

renal cell carcinoma

,

human influenza

,

nutritional status

,

pneumococcal infections

,

pneumococcal pneumonia

,

,

,

systemic lupus erythematosus

,

cutaneous lupus erythematosus

,

inflammatory bowel diseases

,

,

,

tendon injuries

,

,

haemophilus influenzae

,

streptococcus pneumoniae

,

,

,

,

energy metabolism

,

endometrial neoplasms

,

,

mullerian mixed tumor

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

,

non-small-cell lung carcinoma

,

,

neoplasm metastasis

,

,

falciparum malaria

,

ovarian neoplasms

,

brain neoplasms

,

healthy volunteers/patients

,

prostatic neoplasms

,

,

,

colorectal neoplasms

,

squamous cell carcinoma

,

multiple myeloma

,

plasma cell neoplasms

,

ovarian epithelial carcinoma

,

cutaneous malignant melanoma

,

,

type 1 diabetes mellitus

,

triple negative breast neoplasms

,

squamous cell carcinoma of head and neck

,

sickle cell anemia

,

myeloid leukemia acute

,

myeloid leukemia

,

,

,

chronic hepatitis b

,

,

primary myelofibrosis

,

hepatocellular carcinoma

,

liver neoplasms

,

fallopian tube neoplasms

,

pancreatic neoplasms

,

,

hematologic neoplasms

,

ductal carcinoma

,

circulating neoplastic cells

,

uterine neoplasms

,

uterine cervical neoplasms

,

,

streptococcus agalactiae

,

,

follicular lymphoma

,

neisseria meningitidis

,

haemophilus influenzae type b

,

invasive hydatidiform mole

,

biliary tract neoplasms

,

uveal neoplasms

,

respiratory tract diseases

,

respiration disorders

,

,

focal segmental glomerulosclerosis

,

cytomegalovirus infections

,

chronic hepatitis

,

kidney diseases

,

membranous glomerulonephritis

,

nephrotic syndrome

,

,

,

endometrioid carcinoma

,

breast diseases

,

squamous cell neoplasms

,

neurofibromatosis 2

,

acoustic neuroma

,

neurofibromatosis 1

,

neurofibromatoses

,

,

,

,

,

pulmonary tuberculosis

,

adenocarcinoma of lung

,

disease progression

,

peritoneal neoplasms

,

,

beta-thalassemia

,

,

sickle cell trait

,

essential thrombocythemia

,

polycythemia vera

,

,

,

,

,

breast neoplasms

,

,

rheumatoid arthritis

,

,

head and neck neoplasms

,

inflammatory breast neoplasms

,

,

respiratory syncytial virus infections

,

,

bacterial infections

,

,

streptococcal infections

,

,

stomach neoplasms

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

infectious skin diseases

,

bacterial skin diseases

,

ductal carcinoma breast

,

renal insufficiency

,

,

,

,

urinary bladder neoplasms

,

acute coronary syndrome

,

,

rotavirus infections

,

,

mucinous adenocarcinoma

,

,

meningococcal meningitis

,

,

respiratory syncytial viruses

,

,

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

,

acquired immunodeficiency syndrome

,

,

chronic obstructive pulmonary disease

,

communicable diseases

,

,

obstructive lung diseases

,

,

dental focal infection

,

focal infection

,

,

,

immunologic deficiency syndromes

,

ventilator-associated pneumonia

,

growth and development

,

immunologic tests

,

,

alzheimer disease

,

wasting syndrome

,

,

,

insulin resistance

,

abdominal obesity

,

lipid metabolism

,

latent autoimmune diabetes in adults

,

community-acquired infections

,

,

,

staphylococcal infections

,

resistance training

,

,

,

major depressive disorder

,

depressive disorder

,

thyroid neoplasms

,

papillary thyroid cancer

,

thyroid diseases

,

clostridioides difficile

stomach neoplasms

breast neoplasms

,

lobular carcinoma

,

invasive hydatidiform mole

,

thoracic neoplasms

,

glandular and epithelial neoplasms

,

,

,

myelodysplastic syndromes

,

pharmacokinetics

,

soft tissue neoplasms

,

digestive system neoplasms

,

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

endocrine gland neoplasms

,

breast diseases

,

bronchial neoplasms

,

intraductal carcinoma noninfiltrating

,

,

,

pancreatic neoplasms

,

neoplasm metastasis

,

,

b-cell lymphoma

,

castration-resistant prostatic neoplasms

,

large b-cell lymphoma diffuse

,

brain neoplasms

,

non-hodgkin lymphoma

,

t-cell lymphoma

,

,

cholangiocarcinoma

,

neuroendocrine tumors

,

follicular lymphoma

,

myeloid leukemia acute

,

neuroendocrine carcinoma

,

pancreatic ductal carcinoma

,

kidney neoplasms

,

thyroid neoplasms

,

t-cell lymphoma peripheral

,

uterine neoplasms

,

myeloid leukemia

,

uveal neoplasms

,

lymphoid leukemia

,

,

invasive hydatidiform mole

,

female genital neoplasms

,

small cell carcinoma

,

urethral neoplasms

,

ureteral neoplasms

,

colonic neoplasms

,

vulvar neoplasms

,

b-cell lymphoma marginal zone

,

,

thyroid diseases

,

,

microsatellite repeats

,

gastrointestinal neoplasms

,

mouth neoplasms

,

oropharyngeal neoplasms

,

laryngeal neoplasms

,

salivary gland neoplasms

,

endometrioid carcinoma

,

serous cystadenocarcinoma

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

penile neoplasms

,

b-cell chronic lymphocytic leukemia

,

,

,

mullerian mixed tumor

,

,

cutaneous malignant melanoma

,

thymus neoplasms

,

rectal neoplasms

,

hypopharyngeal neoplasms

,

male genital neoplasms

,

bile duct neoplasms

,

respiratory tract infections

,

papillomavirus infections

,

,

adenoid cystic carcinoma

,

,

male breast neoplasms

,

,

malignant fibrous histiocytoma

,

epstein-barr virus infections

,

adenocarcinoma of lung

,

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

,

sezary syndrome

,

mycosis fungoides

,

t-cell lymphoma cutaneous

,

,

pelvic neoplasms

,

hemangiosarcoma

,

,

germ cell and embryonal neoplasms

,

neoplasms by histologic type

,

adenoviridae infections

,

basal cell carcinoma

,

anaplastic thyroid carcinoma

,

reactive arthritis

,

clear cell adenocarcinoma

,

gestational trophoblastic disease

,

alveolar soft part sarcoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

biphenotypic leukemia acute

,

local neoplasm recurrence

,

,

,

meningeal carcinomatosis

,

papillomaviridae

,

second primary neoplasms

,

immunoblastic lymphadenopathy

,

enteropathy-associated t-cell lymphoma

,

intestinal diseases

,

,

carcinoma in situ

,

cervical intraepithelial neoplasia

,

uterine cervical dysplasia

,

squamous intraepithelial lesions of the cervix

,

central nervous system diseases

,

extranodal nk-t-cell lymphoma

,

,

,

,

unknown primary neoplasms

,

synovial sarcoma

,

,

oral leukoplakia

,

,

lymphoproliferative disorders

,

,

colonic diseases

,

histiocytic sarcoma

,

follicular dendritic cell sarcoma

,

interdigitating dendritic cell sarcoma

,

environmental biomarkers

,

circulating neoplastic cells

,

inflammatory breast neoplasms

,

meningeal neoplasms

,

intestinal neoplasms

,

central nervous system neoplasms

,

nervous system neoplasms

,

nervous system diseases

,

nerve tissue neoplasms

,

primitive neuroectodermal tumors

,

neuroepithelial neoplasms

,

neuroectodermal tumors

,

adrenocortical carcinoma

,

carcinoid tumor

,

mediastinal neoplasms

,

testicular neoplasms

,

gastrointestinal stromal tumors

,

hairy cell leukemia

,

burkitt lymphoma

,

laryngeal diseases

,

vaginal neoplasms

,

gallbladder neoplasms

,

acinar cell carcinoma

,

adenomyoepithelioma

,

hereditary breast and ovarian cancer syndrome

,

maxillary sinus neoplasms

,

basal cell neoplasms

,

urogenital neoplasms

,

male urogenital diseases

,

urogenital diseases

,

adenosquamous carcinoma

,

,

,

breast neoplasms

,

colorectal neoplasms

,

,

triple negative breast neoplasms

,

renal cell carcinoma

,

ovarian neoplasms

,

,

,

urinary bladder neoplasms

,

head and neck neoplasms

,

prostatic neoplasms

,

esophageal neoplasms

,

stomach neoplasms

,

liver neoplasms

,

hepatocellular carcinoma

,

endometrial neoplasms

,

uterine cervical neoplasms

,

ovarian epithelial carcinoma

,

small cell lung carcinoma

,

transitional cell carcinoma

,

hodgkin disease

,

fallopian tube neoplasms

,

urologic neoplasms

,

multiple myeloma

,

,

squamous cell neoplasms

,

,

plasma cell neoplasms

,

,

esophageal squamous cell carcinoma

,

malignant mesothelioma

,

biliary tract neoplasms

,

peritoneal neoplasms

,

microsatellite instability

,

merkel cell carcinoma

,

non-muscle invasive bladder neoplasms

,

hematologic neoplasms

,

hypersensitivity

,

nasopharyngeal neoplasms

,

nasopharyngeal carcinoma

,

disease progression

,

muscle neoplasms

,

,

non-small-cell lung carcinoma

,

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

healthy volunteers/patients

,

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

hematologic neoplasms

,

myeloproliferative disorders

,

myelomonocytic leukemia chronic

,

myeloid leukemia

,

myelomonocytic leukemia juvenile

,

,

,

cholangiocarcinoma

,

healthy volunteers/patients

,

drug interactions

,

,

mitochondrial diseases

,

,

hypersensitivity

,

parkinson disease

,

,

ovarian neoplasms

,

ovarian epithelial carcinoma

,

prostatic neoplasms

,

gastrointestinal stromal tumors

,

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

,

rheumatoid arthritis

,

,

sickle cell anemia

,

,

,

,

,

cystic fibrosis

,

,

cardiovascular diseases

,

hypercholesterolemia

,

coronary disease

,

atherosclerosis

,

chronic renal insufficiency

,

kidney diseases

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

,

diabetes complications

,

,

,

bariatric surgery

,

,

pancreatic neoplasms

,

type 1 diabetes mellitus

,

prediabetic state

,

glucose intolerance

,

exocrine pancreatic insufficiency

,

keratoconjunctivitis sicca

,

dry eye syndromes

,

,

human experimentation

,

,

gastrointestinal hemorrhage

,

,

,

,

peptic esophagitis

,

,

,

gastroesophageal reflux

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