Phenylpropanolamine

Capsule, Codamine, Triaminic (phenylpropanolamine) is a small molecule pharmaceutical. Phenylpropanolamine was first approved as Triaminic-12 on 1982-01-01. It is used to treat common cold, obesity, rhinitis, and urinary incontinence in the USA.

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Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
respiratory tract diseases	D012140
otorhinolaryngologic diseases	D010038
urogenital diseases	D000091642
nutritional and metabolic diseases	D009750
signs and symptoms pathological conditions	D013568

Trade Name

FDA

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Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Chlorpheniramine maleate

Phenylpropanolamine hydrochloride

Tradename	Company	Number	Date	Products
TRIAMINIC-12	Novartis	N-018115 DISCN	1982-01-01	1 products

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EMA

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Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
obesity	EFO_0001073	D009765	E66.9
urinary incontinence	—	D014549	R32
rhinitis	EFO_0008521	D012220	J31
common cold	EFO_0007214	D003139	J00
allergic rhinitis perennial	EFO_1001417	D012221	J30.89
urticaria	EFO_0005531	D014581	L50
postoperative pain	—	D010149	G89.18
obstructive lung diseases	—	D008173	—
cough	—	D003371	R05

Agency Specific

FDA

EMA

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Patent Expiration

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ATC Codes

R: Respiratory system drugs

— R01: Nasal preparations

— R01B: Nasal decongestants for systemic use

— R01BA: Sympathomimetics

— R01BA01: Phenylpropanolamine

— R01BA51: Phenylpropanolamine, combinations

HCPCS

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Clinical

Clinical Trials

284 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Overactive urinary bladder	D053201	EFO_1000781	N32.81	6	9	20	15	10	58
Infections	D007239	EFO_0000544	—	—	4	9	13	9	34
Healthy volunteers/patients	—	—	—	21	—	—	3	—	24
Cough	D003371	—	R05	2	3	4	6	5	20
Urinary incontinence	D014549	—	R32	1	2	6	8	2	19
Urge urinary incontinence	D053202	EFO_0006865	N39.41	—	2	7	6	4	19
Helicobacter infections	D016481	EFO_1000961	—	—	3	5	4	4	15
Communicable diseases	D003141	—	—	—	1	8	1	1	10
Respiratory tract infections	D012141	—	J06.9	—	3	3	4	—	9
Type 2 diabetes mellitus	D003924	EFO_0001360	E11	—	2	1	2	1	5

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Pain	D010146	EFO_0003843	R52	—	—	3	—	—	3
Ulcerative colitis	D003093	EFO_0000729	K51	—	—	3	—	—	3
Colitis	D003092	EFO_0003872	K52.9	—	—	3	—	—	3
Ulcer	D014456	MPATH_579	—	—	—	3	—	—	3
Hypotension	D007022	EFO_0005251	I95	—	1	1	—	1	3
Urologic diseases	D014570	—	N39.9	—	—	1	—	1	2
Uveitis	D014605	EFO_1001231	H20.9	—	—	2	—	—	2
Back pain	D001416	—	M54	—	—	1	—	1	2
Inflammatory bowel diseases	D015212	EFO_0003767	—	—	—	2	—	—	2
Intestinal diseases	D007410	—	K63.9	—	—	2	—	—	2

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Syndrome	D013577	—	—	—	1	—	—	3	4
Hypertrophy	D006984	EFO_0002460	—	1	1	—	—	—	2
Neuralgia	D009437	EFO_0009430	—	1	2	—	—	—	2
Inflammation	D007249	MP_0001845	—	—	1	—	—	1	2
Systemic lupus erythematosus	D008180	EFO_0002690	M32	—	2	—	—	—	2
Hiv infections	D015658	EFO_0000764	B20	—	1	—	—	1	2
Ataxia	D001259	—	R27.0	1	2	—	—	—	2
Friedreich ataxia	D005621	Orphanet_95	G11.11	1	2	—	—	—	2
Cerebellar ataxia	D002524	—	—	1	2	—	—	—	2
Vomiting	D014839	—	R11.1	—	1	—	—	1	2

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Hyperplasia	D006965	EFO_0000536	—	2	—	—	—	—	2
Neoplasms	D009369	—	C80	2	—	—	—	—	2
Therapeutic equivalency	D013810	—	—	1	—	—	—	—	1
Non-small-cell lung carcinoma	D002289	—	—	1	—	—	—	—	1
Glioblastoma	D005909	EFO_0000515	—	1	—	—	—	—	1
Mucociliary clearance	D009079	—	—	1	—	—	—	—	1
High-intensity focused ultrasound ablation	D057086	—	—	1	—	—	—	—	1
Alzheimer disease	D000544	EFO_0000249	F03	1	—	—	—	—	1
Low-level light therapy	D028022	—	—	1	—	—	—	—	1

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Lung diseases	D008171	EFO_0003818	J98.4	—	—	—	—	2	2
Whooping cough	D014917	EFO_0000650	A37	—	—	—	—	2	2
Disease progression	D018450	—	—	—	—	—	—	2	2
Irritable bowel syndrome	D043183	EFO_0000555	K58	—	—	—	—	2	2
Diarrhea	D003967	—	R19.7	—	—	—	—	2	2
Obesity	D009765	EFO_0001073	E66.9	—	—	—	—	2	2
Schizophrenia	D012559	EFO_0000692	F20	—	—	—	—	1	1
Psychotic disorders	D011618	—	F20.81	—	—	—	—	1	1
Urinary bladder diseases	D001745	—	N32.9	—	—	—	—	1	1
Female urogenital diseases	D052776	—	—	—	—	—	—	1	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Phenylpropanolamine
INN	phenylpropanolamine
Description	(-)-norephedrine is an amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1R,2S-stereoisomer). It is a plant alkaloid. It has a role as a plant metabolite. It is a member of amphetamines and a phenethylamine alkaloid.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC(N)C(O)c1ccccc1

Identifiers

PDB	—
CAS-ID	14838-15-4
RxCUI	—
ChEMBL ID	CHEMBL61006
ChEBI ID	—
PubChem CID	10297
DrugBank	DB00397
UNII ID	33RU150WUN (ChemIDplus, GSRS)

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Phenylpropanolamine

Codeine

Brompheniramine

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Phenylpropanolamine

Brompheniramine

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Phenylpropanolamine

Chlorpheniramine

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Phenylpropanolamine

Clemastine

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Phenylpropanolamine

Guaifenesin

Codeine

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Phenylpropanolamine

Dextromethorphan

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Phenylpropanolamine

Guaifenesin

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Phenylpropanolamine

Hydrocodone

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Phenylpropanolamine

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Safety

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888 adverse events reported

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