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Drug ReportsPhenylpropanolamine
Phenylpropanolamine
Capsule, Codamine, Triaminic (phenylpropanolamine) is a small molecule pharmaceutical. Phenylpropanolamine was first approved as Triaminic-12 on 1982-01-01. It is used to treat common cold, obesity, rhinitis, and urinary incontinence in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
urogenital diseasesD000091642
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpheniramine maleate
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Phenylpropanolamine hydrochloride
Tradename
Company
Number
Date
Products
TRIAMINIC-12NovartisN-018115 DISCN1982-01-01
1 products
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FDA
EMA
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
obesityEFO_0001073D009765E66.9
urinary incontinence—D014549R32
rhinitisEFO_0008521D012220J31
common coldEFO_0007214D003139J00
allergic rhinitis perennialEFO_1001417D012221J30.89
urticariaEFO_0005531D014581L50
postoperative pain—D010149G89.18
obstructive lung diseases—D008173—
cough—D003371R05
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R01: Nasal preparations
— R01B: Nasal decongestants for systemic use
— R01BA: Sympathomimetics
— R01BA01: Phenylpropanolamine
— R01BA51: Phenylpropanolamine, combinations
HCPCS
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Clinical
Clinical Trials
753 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Respiratory tract infectionsD012141—J06.9——11—2
Common coldD003139EFO_0007214J00———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544———1——1
Communicable diseasesD003141————1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePhenylpropanolamine
INNphenylpropanolamine
Description
(-)-norephedrine is an amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1R,2S-stereoisomer). It is a plant alkaloid. It has a role as a plant metabolite. It is a member of amphetamines and a phenethylamine alkaloid.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
CC(N)C(O)c1ccccc1
Identifiers
PDB—
CAS-ID14838-15-4
RxCUI—
ChEMBL IDCHEMBL61006
ChEBI ID—
PubChem CID10297
DrugBankDB00397
UNII ID33RU150WUN (ChemIDplus, GSRS)
Target
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Variants
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Financial
Revenue by drug
$
€
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Estimated US medical usage
Phenylpropanolamine
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Codeine
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Brompheniramine
Total medical expenditures per year (USD, in millions)
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Phenylpropanolamine
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Brompheniramine
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Phenylpropanolamine
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Chlorpheniramine
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Phenylpropanolamine
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Clemastine
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Phenylpropanolamine
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Guaifenesin
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Codeine
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Phenylpropanolamine
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Dextromethorphan
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Phenylpropanolamine
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Guaifenesin
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Phenylpropanolamine
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Hydrocodone
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Phenylpropanolamine
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,991 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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773 adverse events reported
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