Phenylpropanolamine

Capsule, Codamine, Triaminic (phenylpropanolamine) is a small molecule pharmaceutical. Phenylpropanolamine was first approved as Triaminic-12 on 1982-01-01. It is used to treat common cold, obesity, rhinitis, and urinary incontinence in the USA.

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Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
respiratory tract diseases	D012140
otorhinolaryngologic diseases	D010038
urogenital diseases	D000091642
nutritional and metabolic diseases	D009750
signs and symptoms pathological conditions	D013568

Trade Name

FDA

EMA

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Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Chlorpheniramine maleate

Phenylpropanolamine hydrochloride

Tradename	Company	Number	Date	Products
TRIAMINIC-12	Novartis	N-018115 DISCN	1982-01-01	1 products

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EMA

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Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
obesity	EFO_0001073	D009765	E66.9
urinary incontinence	HP_0000020	D014549	R32
rhinitis	EFO_0008521	D012220	J31
common cold	EFO_0007214	D003139	J00
allergic rhinitis perennial	EFO_1001417	D012221	J30.89
urticaria	EFO_0005531	D014581	L50
postoperative pain	—	D010149	G89.18
obstructive lung diseases	HP_0006536	D008173	—
cough	HP_0012735	D003371	R05

Agency Specific

FDA

EMA

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Patent Expiration

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ATC Codes

R: Respiratory system drugs

— R01: Nasal preparations

— R01B: Nasal decongestants for systemic use

— R01BA: Sympathomimetics

— R01BA01: Phenylpropanolamine

— R01BA51: Phenylpropanolamine, combinations

HCPCS

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Clinical

Clinical Trials

726 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Pain	D010146	EFO_0003843	R52	16	20	17	13	13	75
Postoperative pain	D010149	—	G89.18	5	6	11	33	12	66
Healthy volunteers/patients	—	—	—	50	1	—	2	6	59
Opioid-related disorders	D009293	EFO_0005611	F11	10	12	13	9	16	57
Infections	D007239	EFO_0000544	—	3	6	9	13	9	38
Chronic pain	D059350	HP_0012532	—	3	3	8	8	4	25
Syndrome	D013577	—	—	—	6	6	3	8	23
Cough	D003371	HP_0012735	R05	5	3	8	4	3	23
Neoplasms	D009369	—	C80	8	4	4	2	4	21
Hiv infections	D015658	EFO_0000764	B20	7	3	1	3	5	19

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Cocaine-related disorders	D019970	—	F14	4	3	2	—	—	8
Lymphoma	D008223	—	C85.9	2	2	2	—	1	6
Treatment-resistant depressive disorder	D061218	—	—	1	3	1	—	—	5
Multiple myeloma	D009101	—	C90.0	1	1	2	—	1	5
Amyotrophic lateral sclerosis	D000690	HP_0007354	G12.21	1	3	1	—	—	4
Sclerosis	D012598	—	—	—	3	1	—	—	4
Neoplasm metastasis	D009362	EFO_0009708	—	2	1	1	—	—	4
Peripheral nervous system diseases	D010523	HP_0009830	G64	—	4	1	—	—	4
Psychomotor agitation	D011595	—	—	—	2	1	—	1	4
Rett syndrome	D015518	Orphanet_778	F84.2	—	2	1	—	1	4

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Hyperalgesia	D006930	—	—	1	2	—	—	2	5
Diarrhea	D003967	HP_0002014	R19.7	—	1	—	—	3	4
Motor neuron disease	D016472	EFO_0003782	G12.2	1	3	—	—	—	3
Breast neoplasms	D001943	EFO_0003869	C50	1	1	—	—	2	3
Fibromyalgia	D005356	EFO_0005687	M79.1	2	1	—	—	—	3
Prostatic neoplasms	D011471	—	C61	3	1	—	—	—	3
Spinal cord injuries	D013119	EFO_1001919	—	—	2	—	—	1	3
Parkinson disease	D010300	EFO_0002508	G20	—	2	—	—	1	3
Irritable bowel syndrome	D043183	EFO_0000555	K58	—	1	—	—	2	3
Non-hodgkin lymphoma	D008228	—	C85.9	2	2	—	—	—	3

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Drug interactions	D004347	—	—	6	—	—	—	3	9
Prostatic hyperplasia	D011470	EFO_0000284	N40	3	—	—	—	—	3
Tuberculosis	D014376	EFO_0000774	A15-A19	1	—	—	—	1	2
Food-drug interactions	D018565	—	—	2	—	—	—	—	2
Intervertebral disc degeneration	D055959	HP_0008419	—	1	—	—	—	1	2
Squamous cell carcinoma of head and neck	D000077195	—	—	1	—	—	—	1	2
Renal insufficiency	D051437	HP_0000083	N19	2	—	—	—	—	2
Liver diseases	D008107	HP_0002910	K70-K77	2	—	—	—	—	2
Hepatic insufficiency	D048550	—	—	2	—	—	—	—	2
Melanoma	D008545	—	—	1	—	—	—	—	1

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Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Apnea	D001049	HP_0002104	R06.81	—	—	—	—	2	2
Pneumonia	D011014	EFO_0003106	—	—	—	—	—	2	2
Emergence delirium	D000071257	—	—	—	—	—	—	2	2
Whooping cough	D014917	EFO_0000650	A37.0	—	—	—	—	2	2
Pregnancy rate	D018873	—	—	—	—	—	—	2	2
Obesity	D009765	EFO_0001073	E66.9	—	—	—	—	2	2
Torsades de pointes	D016171	EFO_0005307	I47.21	—	—	—	—	1	1
Cardiovascular diseases	D002318	HP_0001626	—	—	—	—	—	1	1
Post-traumatic stress disorders	D013313	EFO_0001358	F43.1	—	—	—	—	1	1
Traumatic stress disorders	D040921	—	—	—	—	—	—	1	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Phenylpropanolamine
INN	phenylpropanolamine
Description	(-)-norephedrine is an amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1R,2S-stereoisomer). It is a plant alkaloid. It has a role as a plant metabolite. It is a member of amphetamines and a phenethylamine alkaloid.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC(N)C(O)c1ccccc1

Identifiers

PDB	—
CAS-ID	14838-15-4
RxCUI	—
ChEMBL ID	CHEMBL61006
ChEBI ID	—
PubChem CID	10297
DrugBank	DB00397
UNII ID	33RU150WUN (ChemIDplus, GSRS)

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Financial

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Estimated US medical usage

Phenylpropanolamine

Codeine

Brompheniramine

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Phenylpropanolamine

Brompheniramine

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Phenylpropanolamine

Chlorpheniramine

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Phenylpropanolamine

Clemastine

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Phenylpropanolamine

Guaifenesin

Codeine

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Phenylpropanolamine

Dextromethorphan

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Phenylpropanolamine

Guaifenesin

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Phenylpropanolamine

Hydrocodone

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Phenylpropanolamine

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Safety

Black-box Warning

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Adverse Events

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1,036 adverse events reported

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