Phenylbutazone
Azolid, Butazolidin (phenylbutazone) is a small molecule pharmaceutical. Phenylbutazone was first approved as Butazolidin on 1982-01-01. It is used to treat gouty arthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1.
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Commercial
Therapeutic Areas
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| gouty arthritis | — | D015210 | — |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AA: Butylpyrazolidines, antiinflammatory and antirheumatic drugs
— M01AA01: Phenylbutazone
— M01B: Antiinflammatory/antirheumatic agents in combination
— M01BA: Antiinflammatory/antirheumatic agents in combination with corticosteroids
— M01BA01: Phenylbutazone and corticosteroids
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA01: Phenylbutazone
HCPCS
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Clinical
Clinical Trials
1043 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | — | 1 | 10 | 6 | 14 | 17 | 46 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 1 | 2 | 2 | 3 | 9 | 15 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | 2 | — | 2 | — | 4 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 2 | — | 2 | — | 4 |
| Epiretinal membrane | D019773 | — | — | — | 1 | 1 | 1 | 2 | 4 |
| Edema | D004487 | — | R60.9 | — | 1 | — | 1 | 1 | 3 |
| Cataract | D002386 | EFO_0001059 | H26.9 | — | 1 | — | 1 | 1 | 3 |
| Posterior uveitis | D015866 | EFO_1001119 | — | — | — | — | 1 | 1 | 2 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | — | — | 2 | — | 2 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Papilledema | D010211 | EFO_1001074 | H35.81 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 1 | — | — | — | 1 |
| Retinal neovascularization | D015861 | — | H35.05 | — | 1 | — | — | — | 1 |
| Vitrectomy | D014821 | — | — | — | 1 | — | — | — | 1 |
| Radiation injuries | D011832 | — | T66 | — | 1 | — | — | — | 1 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | — | 1 | — | — | — | 1 |
| Uveal melanoma | D000098943 | — | — | — | 1 | — | — | — | 1 |
| Capsule opacification | D058442 | — | H26.4 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Visual acuity | D014792 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Phenylbutazone |
| INN | phenylbutazone |
| Description | Phenylbutazone is a member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position. It has a role as a non-narcotic analgesic, a non-steroidal anti-inflammatory drug, an antirheumatic drug, a peripheral nervous system drug, a metabolite and an EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor. |
| Classification | Small molecule |
| Drug class | anti-inflammatory analgesics (phenylbutazone type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 50-33-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL101 |
| ChEBI ID | 48574 |
| PubChem CID | 4781 |
| DrugBank | DB00812 |
| UNII ID | GN5P7K3T8S (ChemIDplus, GSRS) |
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Safety
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769 adverse events reported
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