Phenylbutazone
Azolid, Butazolidin (phenylbutazone) is a small molecule pharmaceutical. Phenylbutazone was first approved as Butazolidin on 1982-01-01. It is used to treat gouty arthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1.
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| gouty arthritis | — | D015210 | — |
Agency Specific
FDA
EMA
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ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AA: Butylpyrazolidines, antiinflammatory and antirheumatic drugs
— M01AA01: Phenylbutazone
— M01B: Antiinflammatory/antirheumatic agents in combination
— M01BA: Antiinflammatory/antirheumatic agents in combination with corticosteroids
— M01BA01: Phenylbutazone and corticosteroids
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA01: Phenylbutazone
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Clinical
Clinical Trials
1357 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 115 | 209 | 63 | 4 | 9 | 338 |
| Plasma cell neoplasms | D054219 | — | — | 109 | 200 | 60 | 4 | 8 | 320 |
| Leukemia | D007938 | — | C95 | 36 | 66 | 30 | 2 | 6 | 125 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 33 | 58 | 28 | 2 | 5 | 112 |
| Macular edema | D008269 | — | — | 5 | 22 | 21 | 33 | 36 | 112 |
| Lymphoid leukemia | D007945 | — | C91 | 30 | 52 | 23 | 2 | 4 | 98 |
| Lymphoma | D008223 | — | C85.9 | 27 | 55 | 16 | 4 | 2 | 94 |
| Edema | D004487 | HP_0000969 | R60.9 | 5 | 20 | 21 | 21 | 29 | 91 |
| Vomiting | D014839 | HP_0002013 | R11.1 | 3 | 14 | 34 | 21 | 15 | 84 |
| Nausea | D009325 | HP_0002018 | R11.0 | 2 | 13 | 29 | 20 | 12 | 73 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyloidosis | D000686 | EFO_1001875 | E85 | 14 | 18 | 3 | — | 2 | 30 |
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | 11 | 13 | 3 | — | 2 | 25 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 7 | 9 | 4 | — | — | 17 |
| Mantle-cell lymphoma | D020522 | — | — | 3 | 14 | 1 | — | — | 16 |
| Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 4 | 11 | 1 | — | — | 14 |
| Carcinoma | D002277 | — | C80.0 | 2 | 6 | 4 | — | 2 | 13 |
| Myeloid leukemia | D007951 | — | C92 | 6 | 6 | 2 | — | — | 11 |
| Smoldering multiple myeloma | D000075122 | — | — | 2 | 9 | 1 | — | — | 11 |
| Hodgkin disease | D006689 | — | C81 | 4 | 5 | 2 | — | — | 11 |
| Philadelphia chromosome | D010677 | — | — | 1 | 7 | 2 | — | — | 9 |
Show 109 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasmacytoma | D010954 | — | C90.3 | 4 | 6 | — | — | 2 | 11 |
| Hematologic neoplasms | D019337 | — | — | 7 | 5 | — | — | — | 10 |
| Follicular lymphoma | D008224 | — | C82 | 2 | 6 | — | — | — | 7 |
| T-cell leukemia | D015458 | — | — | 2 | 4 | — | — | — | 6 |
| Blast crisis | D001752 | — | — | 2 | 5 | — | — | — | 6 |
| Adenocarcinoma | D000230 | — | — | 3 | 3 | — | — | 1 | 6 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 2 | 5 | — | — | — | 6 |
| Plasma cell leukemia | D007952 | — | C90.1 | 1 | 3 | — | — | 1 | 5 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 1 | 5 | — | — | — | 5 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 1 | — | — | 2 | 4 |
Show 99 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 8 | — | — | — | 1 | 9 |
| Pruritus | D011537 | HP_0000989 | L29 | 2 | — | — | — | 2 | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | 2 | 4 |
| Cesarean section | D002585 | — | — | 1 | — | — | — | 2 | 3 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 3 | — | — | — | — | 3 |
| Endometrioid carcinoma | D018269 | — | — | 1 | — | — | — | 1 | 2 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 1 | — | — | — | 1 | 2 |
| Hairy cell leukemia | D007943 | — | C91.4 | 2 | — | — | — | — | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | 1 | 2 |
| Sleep deprivation | D012892 | — | F51.12 | 2 | — | — | — | — | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Deglutition disorders | D003680 | HP_0002015 | R13.1 | — | — | — | — | 3 | 3 |
| Respiratory sounds | D012135 | HP_0010307 | R06.1 | — | — | — | — | 2 | 2 |
| Ganglion cysts | D045888 | — | M67.4 | — | — | — | — | 2 | 2 |
| Necrosis | D009336 | — | — | — | — | — | — | 2 | 2 |
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | — | 2 | 2 |
| Astigmatism | D001251 | EFO_0004222 | H52.2 | — | — | — | — | 2 | 2 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 2 | 2 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | — | — | — | 2 | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 2 | 2 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | — | 2 | 2 |
Show 77 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Phenylbutazone |
| INN | phenylbutazone |
| Description | Phenylbutazone is a member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position. It has a role as a non-narcotic analgesic, a non-steroidal anti-inflammatory drug, an antirheumatic drug, a peripheral nervous system drug, a metabolite and an EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor. |
| Classification | Small molecule |
| Drug class | anti-inflammatory analgesics (phenylbutazone type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 50-33-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL101 |
| ChEBI ID | 48574 |
| PubChem CID | 4781 |
| DrugBank | DB00812 |
| UNII ID | GN5P7K3T8S (ChemIDplus, GSRS) |
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Safety
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554 adverse events reported
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