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AboutPricing
Drug ReportsPerphenazine
Perphenazine
Perphenazine (perphenazine) is a small molecule pharmaceutical. Perphenazine was first approved as Triavil 2-25 on 1982-01-01. It is used to treat huntington disease, nausea, psychotic disorders, reye syndrome, and schizophrenia amongst others in the USA. The pharmaceutical is active against D(2) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C, histamine H1 receptor, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 6.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Perphenazine (discontinued: Perphenazine, Trilafon)
Combinations
Perphenazine amitriptyline (discontinued: Etrafon, Perphenazine amitriptyline, Triavil)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amitriptyline hydrochloride
+
Perphenazine
Tradename
Company
Number
Date
Products
TRIAVIL 2-25New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
TRIAVIL 4-10New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
TRIAVIL 2-10New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
TRIAVIL 4-25New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
TRIAVIL 4-50New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
ETRAFON-AMerck & CoN-014713 DISCN1982-01-01
1 products
ETRAFON 2-25Merck & CoN-014713 DISCN1982-01-01
1 products
ETRAFON-FORTEMerck & CoN-014713 DISCN1982-01-01
1 products
ETRAFON 2-10Merck & CoN-014713 DISCN1982-01-01
1 products
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Perphenazine
Tradename
Company
Number
Date
Products
TRILAFONMerck & CoN-010775 DISCN1982-01-01
4 products, RLD
TRILAFONMerck & CoN-011213 DISCN1982-01-01
1 products
TRILAFONMerck & CoN-011294 DISCN1982-01-01
1 products
TRILAFONMerck & CoN-011361 DISCN1982-01-01
1 products
TRILAFONMerck & CoN-011557 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
perphenazineANDA2025-11-18
perphenazine and amitriptyline hydrochlorideANDA2025-08-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
substance withdrawal syndromeEFO_0005800D013375—
painEFO_0003843D010146R52
vomiting—D014839R11.1
nausea—D009325R11.0
torticollis—D014103F45.8
tourette syndromeEFO_0004895D005879F95.2
huntington diseaseOrphanet_399D006816G10
schizophreniaEFO_0000692D012559F20
psychotic disorders—D011618F20.81
psychotic affective disorders—D000341F39
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AB: Phenothiazines with piperazine structure, antipsychotics
— N05AB03: Perphenazine
HCPCS
Code
Description
J3310
Injection, perphenazine, up to 5 mg
Q0175
Perphenazine, 4 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen
Clinical
Clinical Trials
34 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20—547621
Psychotic disordersD011618—F20.81—12328
Weight gainD015430——1——1—2
Schizophrenia spectrum and other psychotic disordersD019967—————1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DementiaD003704EFO_0003862F03——2——2
Mental disordersD001523EFO_0000677F91.9——2——2
Postoperative nausea and vomitingD020250EFO_0004888———1——1
VomitingD014839—R11.1——1——1
Psychophysiologic disordersD011602—F45.9——1——1
DepressionD003863—F33.9——1——1
Anxiety disordersD001008EFO_0006788F41.1——1——1
Somatoform disordersD013001—F45——1——1
Disease progressionD018450————1——1
Vascular dementiaD015140—F01——1——1
Show 3 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———31———3
Cocaine-related disordersD019970—F1412———2
Ischemic strokeD000083242———1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug interactionsD004347——1———12
ObesityD009765EFO_0001073E66.91————1
Body weightD001835EFO_0004338—1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bipolar disorderD001714EFO_0000289F30.9————22
StrokeD020521EFO_0000712I63.9————11
Drug-related side effects and adverse reactionsD064420—T88.7————11
RecurrenceD012008——————11
Type 2 diabetes mellitusD003924EFO_0001360E11————11
EmergenciesD004630——————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePerphenazine
INNperphenazine
Description
Perphenazine is a phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and an antiemetic. It is a member of phenothiazines, a N-alkylpiperazine, a N-(2-hydroxyethyl)piperazine and an organochlorine compound. It derives from a hydride of a 10H-phenothiazine.
Classification
Small molecule
Drug classTypical antipsychotic
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
Identifiers
PDB—
CAS-ID58-39-9
RxCUI—
ChEMBL IDCHEMBL567
ChEBI ID8028
PubChem CID4748
DrugBankDB00850
UNII IDFTA7XXY4EZ (ChemIDplus, GSRS)
Target
Agency Approved
DRD2
DRD2
Organism
Homo sapiens
Gene name
DRD2
Gene synonyms
NCBI Gene ID
1813
Protein name
D(2) dopamine receptor
Protein synonyms
Dopamine D2 receptor, seven transmembrane helix receptor
Uniprot ID
Q9UPA9
Mouse ortholog
Drd2 (13489)
D(2) dopamine receptor (Q0VGH9)
Alternate
HTR2A
HTR2A
HTR2C
HTR2C
HRH1
HRH1
HTR7
HTR7
HTR6
HTR6
Organism
Homo sapiens
Gene name
HTR2A
Gene synonyms
HTR2
NCBI Gene ID
3356
Protein name
5-hydroxytryptamine receptor 2A
Protein synonyms
5-HT2 receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, serotonin 5-HT-2A receptor, Serotonin receptor 2A
Uniprot ID
Q5T8C0
Mouse ortholog
Htr2a (15558)
5-hydroxytryptamine receptor 2A (P35363)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Perphenazine
+
Amitriptyline
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Perphenazine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,727 documents
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Safety
Black-box Warning
Black-box warning for: Perphenazine, Perphenazine and amitriptyline hydrochloride
Adverse Events
Top Adverse Reactions
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1,704 adverse events reported
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