Penicillin g procaine
Bicillin C-r, Penicillin G Procaine (penicillin g procaine) is a small molecule pharmaceutical. Penicillin g procaine was first approved as Bicillin c-r on 1982-01-01. It is used to treat actinomycosis, anthrax, bacterial infections, bacterial skin diseases, and botulism amongst others in the USA.
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Penicillin g procaine (discontinued: Duracillin a.s, Penicillin g procaine, Pfizerpen-as)
CombinationsBicillin c-r (discontinued: Bicillin c-r)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Penicillin g benzathine
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Penicillin g procaine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BICILLIN C-R | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
| BICILLIN C-R 900/300 | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bicillin c-r 900/300 | New Drug Application | 2026-07-21 |
| bicillin cr | New Drug Application | 2026-07-21 |
Indications
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Clinical
Clinical Trials
875 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 11 | 23 | 52 | 124 | 70 | 265 |
| Communicable diseases | D003141 | — | — | 1 | 6 | 24 | 42 | 27 | 97 |
| Helicobacter infections | D016481 | EFO_1000961 | — | 4 | 8 | 20 | 39 | 24 | 91 |
| Pneumonia | D011014 | EFO_0003106 | J18 | 5 | 11 | 23 | 19 | 20 | 70 |
| Gastritis | D005756 | EFO_0000217 | K29.7 | 3 | 2 | 7 | 18 | 4 | 33 |
| Healthy volunteers/patients | — | — | — | 19 | — | 1 | 3 | 7 | 30 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | 2 | 3 | 7 | 9 | 10 | 29 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 1 | 5 | 6 | 10 | 7 | 26 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | 1 | 5 | 12 | 6 | 24 |
| Bacterial infections | D001424 | — | A49 | 4 | 3 | 1 | 9 | 6 | 23 |
Show 174 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | — | 5 | 5 | — | 4 | 12 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | 6 | 2 | — | 1 | 9 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 2 | 3 | — | 4 | 7 |
| Abscess | D000038 | EFO_0003030 | — | — | 1 | 3 | — | 2 | 6 |
| Treponemal infections | D014211 | EFO_1001217 | — | — | 1 | 4 | — | — | 5 |
| Leukemia | D007938 | — | C95 | — | 2 | 3 | — | 2 | 5 |
| Hematologic neoplasms | D019337 | — | — | — | 2 | 2 | — | 2 | 5 |
| Multiple myeloma | D009101 | — | C90.0 | — | 2 | 3 | — | 2 | 5 |
| Rheumatic heart disease | D012214 | EFO_1001161 | I09.9 | — | 2 | 1 | — | 2 | 5 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | 2 | — | 1 | 4 |
Show 78 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | — | 3 | 4 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | 4 | — | — | — | 4 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | — | 1 | — | — | 2 | 3 |
| Gastrointestinal microbiome | D000069196 | — | — | — | 1 | — | — | 1 | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | 1 | — | — | 1 | 2 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | — | 1 | — | — | 1 | 2 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 1 | — | — | 1 | 2 |
| Cleft palate | D002972 | EFO_0003920 | Q35 | — | 1 | — | — | 1 | 2 |
| B-cell lymphoma | D016393 | — | — | — | 1 | — | — | 1 | 2 |
| Tonsillectomy | D014068 | — | — | 1 | 1 | — | — | 1 | 2 |
Show 28 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | 2 | 4 |
| Impacted tooth | D014095 | — | K01.1 | 1 | — | — | — | 2 | 3 |
| Drug interactions | D004347 | — | — | 3 | — | — | — | — | 3 |
| Gastrointestinal diseases | D005767 | — | — | 1 | — | — | — | 2 | 3 |
| Digestive system diseases | D004066 | EFO_0000405 | K92.9 | 1 | — | — | — | 2 | 3 |
| Chemical and drug induced liver injury | D056486 | EFO_0004228 | — | 1 | — | — | — | 1 | 2 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | 1 | — | — | — | 1 | 2 |
| Respiration disorders | D012120 | — | J00-J99 | 2 | — | — | — | — | 2 |
| Non-muscle invasive bladder neoplasms | D000093284 | — | — | 2 | — | — | — | — | 2 |
| Jaw fractures | D007572 | — | — | 1 | — | — | — | — | 1 |
Show 14 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kwashiorkor | D007732 | EFO_1001009 | E40 | — | — | — | — | 4 | 4 |
| Hematopoietic stem cell transplantation | D018380 | — | — | — | — | — | — | 2 | 2 |
| Seizures | D012640 | — | G40.4 | — | — | — | — | 2 | 2 |
| Gram-positive bacterial infections | D016908 | — | — | — | — | — | — | 2 | 2 |
| Protein-energy malnutrition | D011502 | EFO_0009563 | E41 | — | — | — | — | 2 | 2 |
| Thyroid nodule | D016606 | EFO_1001436 | — | — | — | — | — | 2 | 2 |
| Periapical periodontitis | D010485 | EFO_1001391 | K04.5 | — | — | — | — | 2 | 2 |
| Gingival recession | D005889 | — | K06.0 | — | — | — | — | 2 | 2 |
| Cachexia | D002100 | — | R64 | — | — | — | — | 2 | 2 |
| Cytokine release syndrome | D000080424 | — | D89.83 | — | — | — | — | 1 | 1 |
Show 111 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Penicillin g procaine |
| INN | — |
| Description | Procaine benzylpenicillin also known as penicillin G procaine, is an antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. It is given by injection into a muscle.
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| Classification | Small molecule |
| Drug class | local anesthetics; penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CCN(CC)CCOC(=O)c1ccc(N)cc1.O |
Identifiers
| PDB | — |
| CAS-ID | 54-35-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200936 |
| ChEBI ID | — |
| PubChem CID | 5903 |
| DrugBank | — |
| UNII ID | — |
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Safety
Black-box Warning
Black-box warning for: Bicillin c-r 900/300, Bicillin cr
Adverse Events
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501 adverse events reported
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