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AboutPricing
Drug ReportsPembrolizumab
Keytruda(pembrolizumab)
Keytruda (pembrolizumab) is an antibody pharmaceutical. Pembrolizumab was first approved as Keytruda on 2014-09-04. It is used to treat hodgkin disease, melanoma, microsatellite instability, non-small-cell lung carcinoma, and squamous cell carcinoma amongst others in the USA. It has been approved in Europe to treat endometrial neoplasms, hodgkin disease, melanoma, non-small-cell lung carcinoma, and renal cell carcinoma amongst others. The pharmaceutical is active against programmed cell death protein 1.
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
respiratory tract diseasesD012140
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
genetic phenomenaD055614
Trade Name
FDA
EMA
Keytruda
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Pembrolizumab
Tradename
Proper name
Company
Number
Date
Products
KeytrudapembrolizumabMerck Sharp & DohmeN-125514 RX2015-01-15
1 products
Show 1 discontinued
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hodgkin disease—D006689C81
melanoma—D008545—
microsatellite instability—D053842—
non-small-cell lung carcinoma—D002289—
squamous cell carcinoma—D002294—
ureteral neoplasmsEFO_0003844D014516C66
urethral neoplasmsEFO_0003846D014523—
urinary bladder neoplasms—D001749C67
Agency Specific
FDA
EMA
Expiration
Code
pembrolizumab, Keytruda, Merck Sharp & Dohme LLC
2028-12-03Orphan excl.
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01F: Monoclonal antibodies and antibody drug conjugates
— L01FF: Pd-1/pdl-1 (programmed cell death protein 1/death ligand 1) inhibitors
— L01FF02: Pembrolizumab
HCPCS
Code
Description
J9271
Injection, pembrolizumab, 1 mg
Clinical
Clinical Trials
2327 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289——16219959329382
MelanomaD008545——13714217129263
Squamous cell carcinoma of head and neckD000077195——72104618163
Pancreatic neoplasmsD010190EFO_0003860C25414011—69
GlioblastomaD005909EFO_0000515—1524—1133
ThymomaD013945——1——1—2
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C802471475—12309
Breast neoplasmsD001943EFO_0003869C5064886—1134
Colorectal neoplasmsD015179——67697—4120
Renal cell carcinomaD002292EFO_0000376—68609—6115
Triple negative breast neoplasmsD064726——55628——108
Stomach neoplasmsD013274EFO_0003897C1644508—283
Ovarian neoplasmsD010051EFO_0003893C5642553—183
Liver neoplasmsD008113EFO_1001513C22.034417—1181
Head and neck neoplasmsD006258——32549—381
Lung neoplasmsD008175HP_0100526C34.90384310—673
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SarcomaD012509——2125———35
LymphomaD008223—C85.92113———27
Non-hodgkin lymphomaD008228—C85.91714———24
Large b-cell lymphoma diffuseD016403—C83.31316———24
Castration-resistant prostatic neoplasmsD064129——1012———20
Follicular lymphomaD008224—C821110———17
Myeloid leukemia acuteD015470—C92.099———16
Neuroendocrine tumorsD018358EFO_1001901D3A.8211———11
Pancreatic ductal carcinomaD021441——310———11
ImmunotherapyD007167——24——510
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeuroblastomaD009447EFO_0000621—2————2
RhabdomyosarcomaD012208——2————2
Lymphoid leukemiaD007945—C912————2
Hiv infectionsD015658EFO_0000764B202————2
Digestive system neoplasmsD004067——2————2
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340—1————1
Myelomonocytic leukemia chronicD015477—C93.11————1
AnemiaD000740HP_0001903D64.91————1
Leukemia myeloid chronic atypical bcr-abl negativeD054438—C92.21————1
ThrombocytosisD013922HP_0001894D75.831————1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Autoimmune diseasesD001327HP_0002960M30-M36————33
Heart diseasesD006331EFO_0003777I51.9————22
MyocarditisD009205—I51.4————22
Interstitial lung diseasesD017563HP_0006530J84.89————22
Cardiovascular diseasesD002318HP_0001626—————11
CardiomyopathiesD009202EFO_0000318I42————11
PericarditisD010493EFO_0007427I30————11
VasculitisD014657HP_0002633—————11
MyositisD009220EFO_0000783G72.49————11
ArthritisD001168HP_0001369M05-M14————11
Show 11 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePembrolizumab
INNpembrolizumab
Description
Pembrolizumab (formerly lambrolizumab, brand name Keytruda) is a humanized antibody used in cancer immunotherapy. This includes to treat melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, and stomach cancer. It is given by slow injection into a vein.
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
>5GGS:A,C|heavy chain QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAY MELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHHHHHH >5GGS:B,D|light chain EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTIS SLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQS GNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Identifiers
PDB5B8C, 5DK3, 5GGS, 5JXE
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL3137343
ChEBI ID—
PubChem CID—
DrugBankDB09037
UNII IDDPT0O3T46P (ChemIDplus, GSRS)
Target
Agency Approved
PDCD1
PDCD1
Organism
Homo sapiens
Gene name
PDCD1
Gene synonyms
PD1
NCBI Gene ID
5133
Protein name
programmed cell death protein 1
Protein synonyms
CD279, programmed cell death 1 protein, protein PD-1, systemic lupus erythematosus susceptibility 2
Uniprot ID
Q8IX89
Mouse ortholog
Pdcd1 (18566)
programmed cell death protein 1 (Q02242)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Keytruda – Merck Sharp & Dohme
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 59,377 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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30,553 adverse events reported
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