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AboutPricing
Drug ReportsPembrolizumab
Keytruda(pembrolizumab)
Keytruda (pembrolizumab) is an antibody pharmaceutical. Pembrolizumab was first approved as Keytruda on 2014-09-04. It is used to treat hodgkin disease, melanoma, microsatellite instability, non-small-cell lung carcinoma, and squamous cell carcinoma amongst others in the USA. It has been approved in Europe to treat endometrial neoplasms, hodgkin disease, melanoma, non-small-cell lung carcinoma, and renal cell carcinoma amongst others. The pharmaceutical is active against programmed cell death protein 1.
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
respiratory tract diseasesD012140
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
genetic phenomenaD055614
Trade Name
FDA
EMA
Keytruda (discontinued: Keytruda)
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Pembrolizumab
Tradename
Proper name
Company
Number
Date
Products
KeytrudapembrolizumabMerck & CoN-125514 RX2015-01-15
1 products
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
keytrudaBiologic Licensing Application2024-12-11
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
non-small-cell lung carcinoma—D002289—
urinary bladder neoplasms—D001749C67
hodgkin disease—D006689C81
melanoma—D008545—
urethral neoplasmsEFO_0003846D014523—
ureteral neoplasmsEFO_0003844D014516C66
squamous cell carcinoma—D002294—
microsatellite instability—D053842—
Agency Specific
FDA
EMA
Expiration
Code
pembrolizumab, Keytruda, Merck Sharp & Dohme LLC
2028-12-03Orphan excl.
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01F: Monoclonal antibodies and antibody drug conjugates
— L01FF: Pd-1/pdl-1 (programmed cell death protein 1/death ligand 1) inhibitors
— L01FF02: Pembrolizumab
HCPCS
Code
Description
J9271
Injection, pembrolizumab, 1 mg
Clinical
Clinical Trials
2526 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CarcinomaD002277—C80.069137341—205
Non-small-cell lung carcinomaD002289——75974011180
MelanomaD008545——54771315114
Squamous cell carcinoma of head and neckD000077195——2756101—79
Squamous cell carcinomaD002294——1857131—78
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C80135951—1177
Lung neoplasmsD008175HP_0100526C34.90517335——134
Breast neoplasmsD001943EFO_0003869C5035688——93
Colorectal neoplasmsD015179——38445——68
LymphomaD008223—C85.926462—162
Triple negative breast neoplasmsD064726——24465——62
Renal cell carcinomaD002292EFO_0000376—30307——51
Ovarian neoplasmsD010051EFO_0003893C5621413——50
AdenocarcinomaD000230——12359——50
RecurrenceD012008——10353—142
Show 34 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C252221———34
Neoplasm metastasisD009362EFO_0009708—1717———26
SarcomaD012509——1019———22
B-cell lymphomaD016393——715———20
Castration-resistant prostatic neoplasmsD064129——512———15
Large b-cell lymphoma diffuseD016403—C83.3610———15
Brain neoplasmsD001932EFO_0003833C71611———14
Non-hodgkin lymphomaD008228—C85.989———12
T-cell lymphomaD016399——210———11
LeukemiaD007938—C9567———10
Show 140 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Thoracic neoplasmsD013899——2————2
Glandular and epithelial neoplasmsD009375——2————2
Lip neoplasmsD008048—C001————1
Eye neoplasmsD005134EFO_0003824C69.91————1
Myelodysplastic syndromesD009190—D461————1
PharmacokineticsD010599——1————1
Soft tissue neoplasmsD012983——1————1
Digestive system neoplasmsD004067——1————1
Lung diseasesD008171HP_0002088J98.41————1
Respiratory tract neoplasmsD012142EFO_0003853D141————1
Show 8 more
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePembrolizumab
INNpembrolizumab
Description
Pembrolizumab (formerly lambrolizumab, brand name Keytruda) is a humanized antibody used in cancer immunotherapy. This includes to treat melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, and stomach cancer. It is given by slow injection into a vein.
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
>5GGS:A,C|heavy chain QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAY MELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHHHHHH >5GGS:B,D|light chain EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTIS SLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQS GNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Identifiers
PDB5B8C, 5DK3, 5GGS, 5JXE
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL3137343
ChEBI ID—
PubChem CID—
DrugBankDB09037
UNII IDDPT0O3T46P (ChemIDplus, GSRS)
Target
Agency Approved
PDCD1
PDCD1
Organism
Homo sapiens
Gene name
PDCD1
Gene synonyms
PD1
NCBI Gene ID
5133
Protein name
programmed cell death protein 1
Protein synonyms
CD279, programmed cell death 1 protein, protein PD-1, systemic lupus erythematosus susceptibility 2
Uniprot ID
Q8IX89
Mouse ortholog
Pdcd1 (18566)
programmed cell death protein 1 (Q02242)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Keytruda – Merck & Co
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 68,132 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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70,298 adverse events reported
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