Pegargiminase
Pegargiminase is an enzyme pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
197 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 4 | 4 | 1 | 1 | 9 |
| Colonoscopy | D003113 | — | — | — | — | — | 3 | 2 | 5 |
| Constipation | D003248 | HP_0002019 | K59.0 | — | — | 1 | 2 | 1 | 4 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 2 | — | 1 | — | 3 |
| Head and neck neoplasms | D006258 | — | — | — | — | — | 1 | 1 | 2 |
| Gastrointestinal hemorrhage | D006471 | HP_0002239 | K92.2 | 1 | — | — | 1 | — | 2 |
| Analgesia | D000698 | — | — | — | — | — | 1 | — | 1 |
| Acromegaly | D000172 | — | — | — | — | — | 1 | — | 1 |
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | — | — | — | 1 | — | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | 1 | — | 1 |
Show 9 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 5 | 4 | 1 | — | — | 8 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | 8 | — | — | 8 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 3 | 4 | 2 | — | — | 8 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 3 | 2 | 2 | — | — | 6 |
| Hepatitis c | D006526 | — | B19.2 | 3 | 4 | 1 | — | — | 5 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 2 | 2 | — | — | 4 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | — | 4 | — | — | 4 |
| Leukemia | D007938 | — | C95 | — | 1 | 2 | — | 1 | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | 2 | 1 | — | — | 3 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 1 | — | — | 2 |
Show 12 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 4 | 4 | — | — | 4 | 10 |
| Neoplasms | D009369 | — | C80 | 5 | 1 | — | — | — | 5 |
| Non-small-cell lung carcinoma | D002289 | — | — | 4 | 1 | — | — | — | 4 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 2 | — | — | — | 4 |
| Prostatic neoplasms | D011471 | — | C61 | 2 | 1 | — | — | — | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 1 | — | — | — | 3 |
| Colorectal neoplasms | D015179 | — | — | 2 | 1 | — | — | 1 | 3 |
| Rhabdomyosarcoma | D012208 | — | — | 1 | 2 | — | — | — | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 1 | — | — | — | 2 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 2 | 1 | — | — | — | 2 |
Show 31 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | 1 | 6 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | — | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | — | — | — | — | 2 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | 2 | — | — | — | — | 2 |
| Hyperuricemia | D033461 | HP_0002149 | — | 2 | — | — | — | — | 2 |
| Gout | D006073 | EFO_0004274 | M10 | 2 | — | — | — | — | 2 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Magnetic resonance imaging | D008279 | — | — | 1 | — | — | — | — | 1 |
| Citrullinemia | D020159 | — | E72.23 | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | — | — | — | — | — | 1 | 1 |
| Transcranial direct current stimulation | D065908 | — | — | — | — | — | — | 1 | 1 |
| Physical therapy modalities | D026741 | — | — | — | — | — | — | 1 | 1 |
| Proprioception | D011434 | — | — | — | — | — | — | 1 | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 1 | 1 |
| Microbiota | D064307 | — | — | — | — | — | — | 1 | 1 |
| Colostomy | D003125 | — | — | — | — | — | — | 1 | 1 |
| Surgical anastomosis | D000714 | — | — | — | — | — | — | 1 | 1 |
| Acute-on-chronic liver failure | D065290 | — | — | — | — | — | — | 1 | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | — | 1 | 1 |
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pegargiminase |
| INN | pegargiminase |
| Description | Pegargiminase (pegylated arginine deiminase) |
| Classification | Enzyme |
| Drug class | enzymes; PEGylated compounds, covalent attachment of macrogol (polyethylene glycol) polymer |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3137346 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 0B7PYQ9YRT (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
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Adverse Events
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