Macugen(pegaptanib octasodium)
Macugen (pegaptanib octasodium) is an unknown pharmaceutical. Pegaptanib octasodium was first approved as Macugen on 2006-01-31. It has been approved in Europe to treat wet macular degeneration.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pegaptanib sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MACUGEN | Bausch Health Companies | N-021756 DISCN | 2004-12-17 | 1 products, RLD |
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Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 1 | 5 | 5 | 6 | 11 | 26 |
| Macular edema | D008269 | — | — | 2 | 5 | 3 | 4 | 3 | 14 |
| Edema | D004487 | HP_0000969 | R60.9 | 2 | 3 | 3 | 2 | 3 | 10 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 2 | 1 | 2 | 1 | 1 | 7 |
| Choroidal neovascularization | D020256 | — | — | — | 1 | 1 | 1 | 3 | 6 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | 1 | 1 | 2 | 1 | 1 | 6 |
| Pathologic neovascularization | D009389 | — | — | 1 | — | 1 | 1 | 2 | 5 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | 2 | 1 | 3 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | 1 | — | 2 | — | 3 |
| Papilledema | D010211 | EFO_1001074 | H35.81 | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 2 | 2 | — | — | 3 |
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | 1 | — | 1 | — | — | 2 |
| Vitreous hemorrhage | D014823 | EFO_0008626 | H43.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
| Cataract | D002386 | HP_0000518 | H26.9 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal neovascularization | D015861 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wet macular degeneration | D057135 | EFO_0004683 | — | — | — | — | — | 5 | 5 |
| Regional blood flow | D012039 | — | — | — | — | — | — | 1 | 1 |
| Uveitis | D014605 | HP_0000554 | H20.9 | — | — | — | — | 1 | 1 |
| Histoplasmosis | D006660 | EFO_0007310 | B39 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pegaptanib octasodium |
| INN | — |
| Description | Macugen (pegaptanib octasodium) is an unknown pharmaceutical. Pegaptanib octasodium was first approved as Macugen on 2006-01-31. It has been approved in Europe to treat wet macular degeneration. |
| Classification | Oligonucleotide |
| Drug class | angiogenesis inhibitors; aptamers, classical and mirror; PEGylated compounds, covalent attachment of macrogol (polyethylene glycol) polymer |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108752 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
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Safety
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552 adverse events reported
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