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AboutPricing
Drug ReportsPaclitaxel
Taxol, Paxene(paclitaxel)
Abraxane, Apealea, Paclitaxel, Pazenir (paclitaxel) is a small molecule pharmaceutical. Paclitaxel was first approved as Taxol on 1992-12-29. It is used to treat breast neoplasms, kaposi sarcoma, non-small-cell lung carcinoma, and ovarian neoplasms in the USA. It has been approved in Europe to treat breast neoplasms, kaposi sarcoma, non-small-cell lung carcinoma, ovarian neoplasms, and pancreatic neoplasms. The pharmaceutical is active against tubulin beta chain. In addition, it is known to target toll-like receptor 4 and nuclear receptor subfamily 1 group I member 2.
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Events Timeline
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YTD
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
digestive system diseasesD004066
respiratory tract diseasesD012140
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
Trade Name
FDA
EMA
Abraxane, Paclitaxel (discontinued: Paclitaxel, Taxol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Paclitaxel
Tradename
Company
Number
Date
Products
PACLITAXELAmerican RegentN-211875 RX2022-07-27
1 products, RLD, RS
ABRAXANEBristol Myers SquibbN-021660 RX2005-01-07
1 products, RLD, RS
PACLITAXELTevaN-216338 RX2023-05-11
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
abraxaneNew Drug Application2022-10-31
anti-empachoC2002632025-07-22
paclitaxelANDA2026-07-11
paclitaxel 100mg per vialANDA2026-08-10
paclitaxel injection,ANDA2009-07-02
paclitaxel protein bound particles albumin boundNew Drug Application2023-05-31
paclitaxel protein-bound particlesANDA2025-04-02
paclitaxel protein-bound particles for injectable suspension (albumin-bound)ANDA2025-09-17
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
ovarian neoplasmsEFO_0003893D010051C56
non-small-cell lung carcinoma—D002289—
kaposi sarcoma—D012514C46
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Paclitaxel, Abraxane, Bristol-Myers
95110462034-01-12U-1434
93933182032-03-04U-1290
95974092032-03-04U-1290
80343752026-08-13U-1290
77588912026-02-21U-1434
82683482026-02-21U-1290
91015432026-02-21U-1434
78207882024-10-27DPU-1092, U-1290, U-1434
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01C: Plant alkaloids and other natural products, antineoplastic drugs
— L01CD: Taxanes, antineoplastic
— L01CD01: Paclitaxel
— L01CD03: Paclitaxel poliglumex
— L01CD51: Paclitaxel and encequidar
HCPCS
Code
Description
J9264
Injection, paclitaxel protein-bound particles, 1 mg
J9267
Injection, paclitaxel, 1 mg
S1016
Non-pvc (polyvinyl chloride) intravenous administration set, for use with drugs that are not stable in pvc e.g., paclitaxel
Clinical
No data
Drug
General
Drug common namePaclitaxel
INNpaclitaxel
Description
Paclitaxel is a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. It has a role as a microtubule-stabilising agent, a metabolite, a human metabolite and an antineoplastic agent. It is a tetracyclic diterpenoid and a taxane diterpenoid. It is functionally related to a baccatin III.
Classification
Small molecule
Drug classantineoplastics, taxane derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C
Identifiers
PDB—
CAS-ID33069-62-4
RxCUI—
ChEMBL IDCHEMBL428647
ChEBI ID45863
PubChem CID36314
DrugBankDB01229
UNII IDP88XT4IS4D (ChemIDplus, GSRS)
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
203068
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
Q9CY33
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
TLR4
TLR4
NR1I2
NR1I2
Organism
Homo sapiens
Gene name
TLR4
Gene synonyms
NCBI Gene ID
7099
Protein name
toll-like receptor 4
Protein synonyms
CD284, homolog of Drosophila toll, hToll, toll like receptor 4 protein
Uniprot ID
Q9UM57
Mouse ortholog
Tlr4 (21898)
toll-like receptor 4 (Q9Z203)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Abraxane – Bristol Myers Squibb
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Abraxane – Celgene
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 104,609 documents
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Safety
Black-box Warning
Black-box warning for: Abraxane, Paclitaxel 100mg per vial, Paclitaxel injection,, Paclitaxel protein bound particles albumin bound, Paclitaxel protein-bound particles, Paclitaxel protein-bound particles for injectable suspension (albumin-bound)
Adverse Events
Top Adverse Reactions
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112,097 adverse events reported
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