PRABOTULINUMTOXIN A
Prabotulinumtoxin a is an unknown pharmaceutical. It is currently being investigated in clinical studies.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| jeuveau | Biologic Licensing Application | 2023-04-28 |
Indications
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Clinical
Clinical Trials
77 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscle spasticity | D009128 | HP_0001257 | — | — | 1 | 2 | 1 | 4 | 8 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 2 | 1 | 3 | — | 6 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 2 | 1 | 1 | 4 |
| Facies | D019066 | — | — | 1 | — | 1 | 1 | — | 3 |
| Cicatrix | D002921 | HP_0100699 | L90.5 | — | 1 | 1 | 1 | — | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | 1 | — | 1 |
| Fissure in ano | D005401 | HP_0012390 | K60.2 | — | — | — | 1 | — | 1 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | — | — | — | 1 | — | 1 |
| Graves ophthalmopathy | D049970 | EFO_1001466 | — | — | — | — | 1 | — | 1 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | — | 1 | — | 1 |
Show 1 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | — | — | 4 | — | 1 | 5 |
| Urinary incontinence | D014549 | HP_0000020 | R32 | — | — | 3 | — | 1 | 4 |
| Enuresis | D004775 | — | R32 | — | — | 3 | — | 1 | 4 |
| Hypertrophy | D006984 | EFO_0002460 | — | — | 1 | 1 | — | — | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | 2 | — | — | 2 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | 2 | — | — | 2 |
| Hypertrophic cicatrix | D017439 | — | L91.0 | — | 1 | 1 | — | — | 1 |
| Urinary bladder diseases | D001745 | — | N32.9 | — | — | 1 | — | — | 1 |
| Headache | D006261 | HP_0002315 | R51 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | 3 | — | — | — | 3 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 3 | — | — | — | 3 |
| Torticollis | D014103 | HP_0000473 | F45.8 | — | 2 | — | — | 1 | 3 |
| Dystonic disorders | D020821 | — | G24 | — | 2 | — | — | 1 | 3 |
| Dystonia | D004421 | HP_0001332 | G24 | — | 2 | — | — | 1 | 3 |
| Clubfoot | D003025 | HP_0008110 | Q66.0 | — | 1 | — | — | 1 | 2 |
| Equinus deformity | D004863 | — | — | — | 1 | — | — | 1 | 2 |
| Talipes | D000070558 | HP_0001883 | Q66.1 | — | 1 | — | — | 1 | 2 |
| Hallux valgus | D006215 | HP_0001822 | — | — | 1 | — | — | — | 1 |
| Cerebral palsy | D002547 | — | G80 | — | 1 | — | — | — | 1 |
Show 8 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Complex regional pain syndromes | D020918 | EFO_1001998 | — | 1 | — | — | — | 2 | 3 |
| Reflex sympathetic dystrophy | D012019 | EFO_1001147 | G90.5 | 1 | — | — | — | 2 | 3 |
| Syndrome | D013577 | — | — | 1 | — | — | — | 1 | 2 |
| Somatoform disorders | D013001 | — | F45 | 1 | — | — | — | — | 1 |
| Blepharospasm | D001764 | — | G24.5 | 1 | — | — | — | — | 1 |
| Skin aging | D015595 | EFO_0005422 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemiplegia | D006429 | HP_0011099 | G81.0 | — | — | — | — | 2 | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 2 | 2 |
| Vaginismus | D052065 | — | N94.2 | — | — | — | — | 1 | 1 |
| Cosmetic techniques | D003357 | — | — | — | — | — | — | 1 | 1 |
| Neurologic gait disorders | D020233 | HP_0003376 | R26.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PRABOTULINUMTOXIN A |
| INN | — |
| Description | Botulinum toxin, or botulinum neurotoxin, is a highly potent neurotoxic protein produced by the bacterium Clostridium botulinum and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. The toxin causes the disease botulism. The toxin is also used commercially for medical and cosmetic purposes.
|
| Classification | Neurotoxin |
| Drug class | fluoroquinolone derivatives, nonantibacterial indication (e.g., antineoplastic antibiotics) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297229 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00083 |
| UNII ID | — |
Target
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Trends
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Safety
Black-box Warning
Black-box warning for: Jeuveau
Adverse Events
Top Adverse Reactions
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2,824 adverse events reported
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