Orgotein
Orgotein is an unknown pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
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Clinical Trials
130 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | 12 | 6 | 4 | 1 | 10 | 28 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 1 | — | 2 | 3 | 6 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | 1 | 1 | 3 | 5 |
| Sphincter of oddi dysfunction | D046628 | — | — | — | — | 1 | 1 | 2 | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | 1 | 1 | 2 | 4 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | — | — | 1 | 1 | 2 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | 1 | — | 1 | — | 2 |
| Frailty | D000073496 | — | R53.1 | — | — | — | 1 | — | 1 |
| Male breast neoplasms | D018567 | — | — | — | — | — | 1 | — | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | 1 | — | 1 |
Show 9 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | 9 | 4 | 3 | — | 8 | 20 |
| Sclerosis | D012598 | — | — | 8 | 3 | 2 | — | 8 | 18 |
| Postoperative complications | D011183 | — | — | — | 1 | 1 | — | 1 | 3 |
| Head and neck neoplasms | D006258 | — | — | 1 | — | 1 | — | — | 2 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | 1 | 1 | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | 1 | — | 1 | 2 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | 1 | — | — | 1 |
| Mucositis | D052016 | EFO_1001898 | — | — | — | 1 | — | — | 1 |
| Common bile duct diseases | D003137 | — | — | — | — | 1 | — | — | 1 |
| Seizures | D012640 | — | G40.4 | — | — | 1 | — | — | 1 |
Show 4 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | 1 | — | — | 1 | 8 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 2 | 3 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 1 | — | — | 2 | 3 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 1 | — | — | 1 | 2 |
| Reperfusion injury | D015427 | — | — | — | 1 | — | — | 1 | 2 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 1 | — | — | — | 2 |
| Periodontal diseases | D010510 | — | K05.6 | — | 1 | — | — | 1 | 2 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | 1 | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | 1 | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 1 |
Show 9 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Oxidative stress | D018384 | EFO_1001905 | — | 1 | — | — | — | 8 | 9 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | 3 | 4 |
| Male infertility | D007248 | EFO_0004248 | N46 | 1 | — | — | — | 2 | 3 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | 1 | — | — | — | — | 1 |
| Squamous cell neoplasms | D018307 | — | — | 1 | — | — | — | — | 1 |
| Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | 1 | — | — | — | — | 1 |
| Hypoxia | D000860 | — | R09.02 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscle strength | D053580 | — | — | — | — | — | — | 3 | 3 |
| Resistance training | D055070 | — | — | — | — | — | — | 3 | 3 |
| Infertility | D007246 | EFO_0000545 | — | — | — | — | — | 2 | 2 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | — | — | 2 | 2 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 2 | 2 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 2 | 2 |
| Body composition | D001823 | — | — | — | — | — | — | 2 | 2 |
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 2 | 2 |
| Peripheral nervous system diseases | D010523 | — | G64 | — | — | — | — | 2 | 2 |
| Pregnancy-induced hypertension | D046110 | — | O13 | — | — | — | — | 2 | 2 |
Show 79 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Orgotein |
| INN | orgotein |
| Description | Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O−2) radical into ordinary molecular oxygen (O2) and hydrogen peroxide (H2O2). Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage. Hydrogen peroxide is also damaging and is degraded by other enzymes such as catalase. Thus, SOD is an important antioxidant defense in nearly all living cells exposed to oxygen. One exception is Lactobacillus plantarum and related lactobacilli, which use a different mechanism to prevent damage from reactive O−2.
|
| Classification | Unknown |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108545 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | PKE82W49V1 (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
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Adverse Events
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362,014 adverse events reported
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