Orgotein
Orgotein is an unknown pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
115 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 1 | — | 2 | 3 | 6 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | 1 | 1 | 3 | 5 |
| Sphincter of oddi dysfunction | D046628 | — | — | — | — | 1 | 1 | 2 | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | 1 | 1 | 2 | 4 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | 1 | — | 1 | — | 2 |
| Frailty | D000073496 | — | R53.1 | — | — | — | 1 | — | 1 |
| Male breast neoplasms | D018567 | — | — | — | — | — | 1 | — | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | 1 | — | 1 |
| Paresthesia | D010292 | — | R20.2 | — | — | — | 1 | — | 1 |
| Postcholecystectomy syndrome | D017562 | EFO_1001117 | K91.5 | — | — | — | 1 | — | 1 |
Show 7 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | 10 | 5 | 4 | — | 9 | 23 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | 10 | 5 | 3 | — | 9 | 22 |
| Sclerosis | D012598 | — | — | 9 | 4 | 2 | — | 8 | 19 |
| Head and neck neoplasms | D006258 | — | — | 1 | — | 1 | — | — | 2 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | 1 | 1 | — | — | 2 |
| Mucositis | D052016 | EFO_1001898 | — | — | 1 | 1 | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | 1 | — | 1 | 2 |
| Postoperative complications | D011183 | — | — | — | 1 | 1 | — | — | 2 |
| Fatigue | D005221 | — | R53.83 | — | — | 1 | — | 1 | 2 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | 1 | — | — | 1 |
Show 5 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | 1 | — | — | 1 | 8 |
| Peripheral nervous system diseases | D010523 | — | G64 | — | 1 | — | — | 2 | 3 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 1 | — | — | 2 | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 1 | 2 |
| Periodontal diseases | D010510 | — | K05.6 | — | 1 | — | — | 1 | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | — | 1 |
| Reperfusion injury | D015427 | — | — | — | 1 | — | — | — | 1 |
| Myocardial reperfusion injury | D015428 | EFO_0002687 | — | — | 1 | — | — | — | 1 |
| Dermatitis | D003872 | — | L30.9 | 1 | 1 | — | — | — | 1 |
Show 6 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Oxidative stress | D018384 | EFO_1001905 | — | 1 | — | — | — | 6 | 7 |
| Male infertility | D007248 | EFO_0004248 | N46 | 1 | — | — | — | 2 | 3 |
| Infertility | D007246 | EFO_0000545 | — | 1 | — | — | — | 2 | 3 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | 1 | 2 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | 1 | — | — | — | — | 1 |
| Squamous cell neoplasms | D018307 | — | — | 1 | — | — | — | — | 1 |
| Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | 1 | — | — | — | — | 1 |
| Hypoxia | D000860 | — | R09.02 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscle strength | D053580 | — | — | — | — | — | — | 3 | 3 |
| Resistance training | D055070 | — | — | — | — | — | — | 3 | 3 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | — | — | 2 | 2 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 2 | 2 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 2 | 2 |
| Body composition | D001823 | — | — | — | — | — | — | 2 | 2 |
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 2 | 2 |
| Lipid peroxidation | D015227 | — | — | — | — | — | — | 1 | 1 |
| Endoscopy | D004724 | — | — | — | — | — | — | 1 | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 1 | 1 |
Show 69 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Orgotein |
| INN | orgotein |
| Description | Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O−2) radical into ordinary molecular oxygen (O2) and hydrogen peroxide (H2O2). Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage. Hydrogen peroxide is also damaging and is degraded by other enzymes such as catalase. Thus, SOD is an important antioxidant defense in nearly all living cells exposed to oxygen. One exception is Lactobacillus plantarum and related lactobacilli, which use a different mechanism to prevent damage from reactive O−2.
|
| Classification | Unknown |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108545 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | PKE82W49V1 (ChemIDplus, GSRS) |
Target
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Trends
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Safety
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Adverse Events
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