Ofloxacin
Ocuflox, Ofloxacin (ofloxacin) is a small molecule pharmaceutical. Ofloxacin was first approved as Floxin on 1990-12-28. It is used to treat bacterial conjunctivitis, bacterial infections, bacterial skin diseases, bronchitis, and chlamydia infections amongst others in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Ocuflox, Ofloxacin (discontinued: Floxin, Ofloxacin)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ocuflox | New Drug Application | 2024-06-13 |
| ofloxacin | ANDA | 2024-12-24 |
| ofloxacin ophth soln | ANDA | 2023-05-22 |
| ofloxacin ophthalmic | ANDA | 2022-10-28 |
| ofloxacin otic | ANDA | 2024-12-26 |
Indications
FDA
EMA
Show 13 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01M: Quinolone antibacterials
— J01MA: Fluoroquinolone antibacterials, systemic
— J01MA01: Ofloxacin
— J01R: Combinations of antibacterials
— J01RA: Combinations of antibacterials
— J01RA09: Ofloxacin and ornidazole
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AE: Fluoroquinolone antiinfectives, ophthalmologic
— S01AE01: Ofloxacin
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA16: Ofloxacin
Clinical
Clinical Trials
418 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 5 | 8 | 30 | 50 | 30 | 120 |
| Communicable diseases | D003141 | — | — | 1 | 3 | 19 | 20 | 15 | 57 |
| Helicobacter infections | D016481 | EFO_1000961 | — | — | — | 4 | 23 | 13 | 40 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 4 | 10 | 17 | 5 | 8 | 38 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 6 | 15 | 10 | 2 | 31 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | 3 | 3 | 10 | 7 | 3 | 24 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | — | 6 | 8 | 3 | 3 | 18 |
| Cataract | D002386 | HP_0000518 | H26.9 | 4 | 1 | 3 | 7 | 2 | 17 |
| Disease susceptibility | D004198 | — | — | — | — | 2 | 10 | 2 | 14 |
| Healthy volunteers/patients | — | — | — | 8 | 1 | — | 3 | 2 | 14 |
Show 89 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute disease | D000208 | — | — | — | 2 | 5 | — | 2 | 8 |
| Otitis | D010031 | — | — | — | 2 | 6 | — | 1 | 7 |
| Prostatitis | D011472 | EFO_0003830 | N41 | — | 1 | 5 | — | 1 | 7 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | — | 1 | — | 3 | 6 |
| Rhinosinusitis | D000096825 | — | — | 1 | 2 | 3 | — | 1 | 6 |
| Bacterial infections | D001424 | — | A49 | 1 | — | 3 | — | 2 | 6 |
| Fibrosis | D005355 | — | — | 2 | 1 | 2 | — | — | 5 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 2 | 1 | 2 | — | — | 5 |
| Bacterial conjunctivitis | D003234 | EFO_1000829 | H10.0 | 1 | 3 | 2 | — | — | 5 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | 1 | — | 4 | 5 |
Show 60 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myopia | D009216 | EFO_0003927 | H52.1 | 1 | 1 | — | — | 4 | 5 |
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | 2 | 2 | — | — | — | 3 |
| Pulmonary sarcoidosis | D017565 | DOID_13406 | D86.0 | 1 | 1 | — | — | — | 2 |
| Antibiotic prophylaxis | D019072 | — | — | — | 1 | — | — | 1 | 2 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | 1 | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | — | — | — | 1 |
| Meningeal tuberculosis | D014390 | — | A17.0 | 1 | 1 | — | — | — | 1 |
| Pterygium | D011625 | — | H11.0 | 1 | 1 | — | — | — | 1 |
| Corneal diseases | D003316 | — | H18.9 | 1 | 1 | — | — | — | 1 |
| Hyperopia | D006956 | EFO_0006310 | H52.0 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | 1 | — | — | — | 1 | 2 |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 1 | — | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | 1 | — | — | — | — | 1 |
| Hearing loss | D034381 | EFO_0004238 | H91.9 | 1 | — | — | — | — | 1 |
| Ototoxicity | D000081015 | — | — | 1 | — | — | — | — | 1 |
| Deafness | D003638 | EFO_0001063 | H91.9 | 1 | — | — | — | — | 1 |
| Escherichia coli infections | D004927 | EFO_1001318 | B96.20 | 1 | — | — | — | — | 1 |
| Sars-cov-2 | D000086402 | — | — | 1 | — | — | — | — | 1 |
| Short bowel syndrome | D012778 | — | K90.82 | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 5 | 5 |
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | — | — | — | 3 | 3 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 3 | 3 |
| Endometritis | D004716 | EFO_1001312 | — | — | — | — | — | 3 | 3 |
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 3 | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 3 | 3 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | — | — | 3 | 3 |
| Cerebral infarction | D002544 | — | I63 | — | — | — | — | 3 | 3 |
| Prosthesis-related infections | D016459 | EFO_1001406 | — | — | — | — | — | 2 | 2 |
| Chemical and drug induced liver injury | D056486 | EFO_0004228 | — | — | — | — | — | 2 | 2 |
Show 61 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Ofloxacin |
| INN | ofloxacin |
| Description | Ofloxacin is a racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. It has a role as a DNA synthesis inhibitor, an antiinfective agent, an antibacterial drug, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor and a topoisomerase IV inhibitor. It is a quinolone antibiotic, a fluoroquinolone antibiotic and a racemate. It contains a levofloxacin and a dextrofloxacin. |
| Classification | Small molecule |
| Drug class | antibacterials (quinolone derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23 |
Identifiers
| PDB | — |
| CAS-ID | 82419-36-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4 |
| ChEBI ID | 7731 |
| PubChem CID | 4583 |
| DrugBank | DB01165 |
| UNII ID | A4P49JAZ9H (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Ofloxacin
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 19,180 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
98,158 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use