ONVANSERTIB
Onvansertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against serine/threonine-protein kinase PLK1. In addition, it is known to target serine/threonine-protein kinase PLK2, serine/threonine-protein kinase PLK3, and receptor-type tyrosine-protein kinase FLT3.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
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YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ONVANSERTIB |
| INN | onvansertib |
| Description | Onvansertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against serine/threonine-protein kinase PLK1. In addition, it is known to target serine/threonine-protein kinase PLK2, serine/threonine-protein kinase PLK3, and receptor-type tyrosine-protein kinase FLT3. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCN(c2ccc(OC(F)(F)F)c(Nc3ncc4c(n3)-c3c(c(C(N)=O)nn3CCO)CC4)c2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1034616-18-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1738758 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 67RM91WDHQ (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PLK3
PLK3
Organism
Homo sapiens
Gene name
PLK3
Gene synonyms
CNK, FNK, PRK
NCBI Gene ID
Protein name
serine/threonine-protein kinase PLK3
Protein synonyms
Cytokine-inducible serine/threonine-protein kinase, FGF-inducible kinase, PLK-3, Polo-like kinase 3, Proliferation-related kinase
Uniprot ID
Mouse ortholog
Plk3 (12795)
serine/threonine-protein kinase PLK3 (Q9R009)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 199 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10 adverse events reported
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