Nitrofurazone
Actin-n, Furacin (nitrofurazone) is a small molecule pharmaceutical. Nitrofurazone was first approved as Actin-n on 1982-01-01. It is used to treat burns, clostridium infections, escherichia coli infections, proteus infections, and staphylococcal skin infections amongst others in the USA.
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Nitrofurazone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ACTIN-N | Sherwood Medical | N-017343 DISCN | 1982-01-01 | 1 products |
| FURACIN | Shire | N-005795 DISCN | 1982-01-01 | 1 products |
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ATC Codes
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CA: Antiinfective irrigating solutions
— B05CA03: Nitrofural
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AF: Nitrofuran derivatives, antiseptics and disinfectants
— D08AF01: Nitrofural
— D09: Medicated dressings
— D09A: Medicated dressings
— D09AA: Medicated dressings with antiinfectives
— D09AA03: Nitrofural
P: Antiparasitic products, insecticides and repellents
— P01: Antiprotozoals
— P01C: Agents against leishmaniasis and trypanosomiasis
— P01CC: Nitrofuran derivatives, antiprotozoal drugs
— P01CC02: Nitrofural
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AX: Other antiinfectives in atc
— S01AX04: Nitrofural
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA02: Nitrofural
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Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | — | — | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | 1 | — | — | 1 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscular atrophy | D009133 | HP_0003202 | — | 3 | 2 | — | — | — | 3 |
| Spinal muscular atrophy | D009134 | EFO_0003823 | G12.1 | 3 | 2 | — | — | — | 3 |
| Atrophy | D001284 | — | — | 3 | 2 | — | — | — | 3 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | — | 1 | — | — | — | 1 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 1 | — | — | — | 1 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Spinal muscular atrophies of childhood | D014897 | Orphanet_83419 | G12.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Immunotherapy | D007167 | — | — | — | — | — | — | 3 | 3 |
| Melanoma | D008545 | — | — | — | — | — | — | 2 | 2 |
| Microbiota | D064307 | — | — | — | — | — | — | 2 | 2 |
| Metagenome | D054892 | — | — | — | — | — | — | 2 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | — | — | 2 | 2 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 1 | 1 |
| High-throughput nucleotide sequencing | D059014 | — | — | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
| Colonic neoplasms | D003110 | — | C18 | — | — | — | — | 1 | 1 |
| Pilonidal sinus | D010864 | HP_0010769 | L05 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nitrofurazone |
| INN | nitrofural |
| Description | Nitrofurazone (INN, trade name Furacin) is an antimicrobial organic compound belonging to the nitrofuran class. It is most commonly used as a topical antibiotic ointment. It is effective against gram-positive bacteria, gram-negative bacteria, and can be used in the treatment of trypanosomiasis. Its use in medicine has become less frequent, as safer and more effective products have become available. Nitrofurazone is listed under California Prop 65, and has demonstrated clear evidence to be mutagenic and carcinogenic during animal studies, and has been discontinued for human use in the USA. The substance is pale yellow and crystalline. It was once widely used as an antibiotic for livestock.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)N/N=C/c1ccc([N+](=O)[O-])o1 |
Identifiers
| PDB | — |
| CAS-ID | 59-87-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL869 |
| ChEBI ID | — |
| PubChem CID | 1839 |
| DrugBank | DB00336 |
| UNII ID | X8XI70B5Z6 (ChemIDplus, GSRS) |
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65 adverse events reported
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