Tradename | Company | Number | Date | Products |
---|---|---|---|---|
AKEEGA | Johnson & Johnson | N-216793 RX | 2023-08-11 | 2 products, RLD, RS |
Expiration | Code | ||
---|---|---|---|
NIRAPARIB TOSYLATE, ZEJULA, GLAXOSMITHKLINE | |||
2027-04-29 | ODE-295 | ||
2026-10-23 | ODE-277 | ||
2024-03-27 | ODE-133 | ||
ABIRATERONE ACETATE / NIRAPARIB TOSYLATE, AKEEGA, JANSSEN BIOTECH | |||
2026-08-11 | NP |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Niraparib Tosylate, Zejula, Glaxosmithkline | |||
11730725 | 2039-01-04 | DP | |
Abiraterone Acetate / Niraparib Tosylate, Akeega, Janssen Biotech | |||
11091459 | 2038-03-27 | DP | |
11673877 | 2038-03-27 | DP | U-3646, U-3647 |
11207311 | 2037-07-28 | U-2830 | |
8859562 | 2031-08-04 | U-2655, U-2830 | |
8071623 | 2031-03-27 | DS, DP | |
8436185 | 2029-04-24 | DP | |
8071579 | 2027-08-12 | U-2655, U-2830 | |
8143241 | 2027-08-12 | U-2655, U-2830 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Prostatic neoplasms | D011471 | — | C61 | 5 | 5 | 3 | — | 2 | 12 |
Castration-resistant prostatic neoplasms | D064129 | — | — | 2 | 2 | 2 | — | 1 | 5 |
Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | 1 | — | — | 1 |
Drug common name | Niraparib |
INN | niraparib |
Description | Niraparib is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. It has a role as an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a radiosensitizing agent and an apoptosis inducer. |
Classification | Small molecule |
Drug class | poly-ADP-ribose polymerase inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12 |
PDB | — |
CAS-ID | 1038915-60-4 |
RxCUI | — |
ChEMBL ID | CHEMBL1094636 |
ChEBI ID | — |
PubChem CID | 24958200 |
DrugBank | DB11793 |
UNII ID | HMC2H89N35 (ChemIDplus, GSRS) |