Niclosamide
Niclocide (niclosamide) is a small molecule pharmaceutical. Niclosamide was first approved as Niclocide on 1982-05-14. It is used to treat helminthiasis in the USA. It is known to target potassium channel subfamily T member 1 and neuropeptide Y receptor type 4-2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| helminthiasis | EFO_1001342 | D006373 | B65-B83 |
Agency Specific
FDA
EMA
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Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
35 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | 4 | 10 | 3 | 1 | — | 16 |
| Treatment outcome | D016896 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | — | 3 | 1 | — | — | 3 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | — | 1 | — | — | 1 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | 1 | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 2 | 1 | — | — | — | 3 |
| Carcinoma | D002277 | — | C80.0 | 2 | 1 | — | — | — | 3 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | 1 | — | — | — | 1 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 1 | 1 | — | — | — | 1 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 1 | — | — | — | 1 |
| Adenomatous polyposis coli | D011125 | — | D13.91 | — | 1 | — | — | — | 1 |
| Nasopharyngeal neoplasms | D009303 | — | — | — | 1 | — | — | — | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | 1 | 1 | — | — | — | 1 |
| Proctitis | D011349 | EFO_0005628 | K62.89 | 1 | 1 | — | — | — | 1 |
| Proctocolitis | D011350 | EFO_1001223 | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | — | 1 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Taeniasis | D013622 | EFO_1001433 | B68 | — | — | — | — | 1 | 1 |
| Parasitic intestinal diseases | D007411 | EFO_0009561 | B82 | — | — | — | — | 1 | 1 |
| Urinary incontinence | D014549 | HP_0000020 | R32 | — | — | — | — | 1 | 1 |
| Stress urinary incontinence | D014550 | HP_0010992 | — | — | — | — | — | 1 | 1 |
| Enuresis | D004775 | — | R32 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Niclosamide |
| INN | niclosamide |
| Description | Niclosamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections. It has a role as a piscicide, a molluscicide, an antiparasitic agent, an anticoronaviral agent, an anthelminthic drug, an apoptosis inducer and a STAT3 inhibitor. It is a member of monochlorobenzenes, a member of salicylanilides, a C-nitro compound, a secondary carboxamide and a member of benzamides. It is functionally related to a 5-chlorosalicylic acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O |
Identifiers
| PDB | — |
| CAS-ID | 50-65-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1448 |
| ChEBI ID | — |
| PubChem CID | 4477 |
| DrugBank | DB06803 |
| UNII ID | 8KK8CQ2K8G (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNT1
KCNT1
NPY4R2
NPY4R2
Organism
Homo sapiens
Gene name
KCNT1
Gene synonyms
KIAA1422
NCBI Gene ID
Protein name
potassium channel subfamily T member 1
Protein synonyms
KCa4.1, potassium channel, sodium activated subfamily T, member 1, potassium channel, subfamily T, member 1, Sequence like a calcium-activated K+ channel
Uniprot ID
Mouse ortholog
Kcnt1 (227632)
potassium channel subfamily T member 1 (Q8C3E7)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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