Neostigmine
Bloxiverz, Neostigmine Methylsulfate, Prevduo (neostigmine) is a small molecule pharmaceutical. Neostigmine was first approved as Bloxiverz on 2013-05-31. It is used to treat drug-induced abnormalities, myasthenia gravis, urinary bladder diseases, and urinary retention in the USA. It is known to target acetylcholinesterase.
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Commercial
Trade Name
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Bloxiverz (generic drugs available since 2015-12-28)
CombinationsPrevduo
Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Glycopyrrolate
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Neostigmine methylsulfate
Neostigmine methylsulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BLOXIVERZ | Exela Pharma Sciences | N-204078 RX | 2013-05-31 | 3 products, RLD, RS |
| NEOSTIGMINE METHYLSULFATE | Fresenius Kabi | N-203629 RX | 2015-01-08 | 3 products, RLD, RS |
Labels
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EMA
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Indications
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EMA
Agency Specific
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ATC Codes
N: Nervous system drugs
— N07: Other nervous system drugs in atc
— N07A: Parasympathomimetics
— N07AA: Anticholinesterase parasympathomimetics
— N07AA01: Neostigmine
— N07AA51: Neostigmine, combinations
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EB: Parasympathomimetics, antiglaucoma preparations and miotics
— S01EB06: Neostigmine
HCPCS
Code | Description |
|---|---|
| J2710 | Injection, neostigmine methylsulfate, up to 0.5 mg |
Clinical
Clinical Trials
248 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuromuscular blockade | D019148 | — | — | 2 | 4 | 6 | 25 | 10 | 46 |
| Delayed emergence from anesthesia | D055191 | — | — | — | 2 | — | 9 | 8 | 19 |
| Postoperative pain | D010149 | — | G89.18 | 1 | 2 | 1 | 2 | 5 | 10 |
| General anesthesia | D000768 | — | — | 1 | 3 | 5 | 1 | 1 | 10 |
| Anesthesia | D000758 | — | — | — | — | 2 | 3 | 2 | 7 |
| Post-dural puncture headache | D051299 | — | — | — | 1 | 1 | 3 | — | 5 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | 4 | — | — | 1 | — | 5 |
| Postoperative complications | D011183 | — | — | — | 1 | — | 2 | 1 | 4 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | 1 | 1 | 2 | 4 |
| Muscle relaxation | D009126 | — | — | — | — | — | 3 | — | 3 |
Show 40 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Morbid obesity | D009767 | EFO_0001074 | — | — | 1 | 1 | — | 2 | 3 |
| Hypospadias | D007021 | EFO_0004209 | Q54 | — | 1 | 1 | — | — | 1 |
| Burns | D002056 | — | T30.0 | — | — | 1 | — | — | 1 |
| Muscle fatigue | D018763 | — | — | — | — | 1 | — | — | 1 |
| Elective surgical procedures | D017558 | — | — | — | — | 1 | — | — | 1 |
| Replacement arthroplasty knee | D019645 | — | — | — | — | 1 | — | — | 1 |
| Replacement arthroplasty hip | D019644 | — | — | — | — | 1 | — | — | 1 |
| Blood coagulation | D001777 | GO_0007596 | — | — | — | 1 | — | — | 1 |
| Knee injuries | D007718 | — | — | — | 1 | 1 | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | — | 1 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Septic shock | D012772 | — | A48.3 | — | 1 | — | — | — | 1 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | 1 | — | — | — | 1 |
| Intra-abdominal hypertension | D059325 | — | — | — | 1 | — | — | — | 1 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | 1 | 1 | — | — | — | 1 |
| Obstructive jaundice | D041781 | EFO_1001068 | — | 1 | 1 | — | — | — | 1 |
| Urinary retention | D016055 | HP_0000016 | R33 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neurogenic bowel | D055496 | EFO_1001061 | K59.2 | 4 | — | — | — | — | 4 |
| Constipation | D003248 | HP_0002019 | K59.0 | 2 | — | — | — | 1 | 3 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | — | — | — | — | 1 |
| Labor pain | D048949 | — | — | 1 | — | — | — | — | 1 |
| Fecal incontinence | D005242 | — | R15 | 1 | — | — | — | — | 1 |
| Snoring | D012913 | — | R06.83 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Critical illness | D016638 | — | — | — | — | — | — | 3 | 3 |
| Delirium | D003693 | — | R41.0 | — | — | — | — | 2 | 2 |
| Gallbladder diseases | D005705 | EFO_0003832 | K82.9 | — | — | — | — | 2 | 2 |
| Acute pain | D059787 | — | R52 | — | — | — | — | 2 | 2 |
| Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | — | — | — | — | 2 | 2 |
| Analgesia | D000698 | — | — | — | — | — | — | 2 | 2 |
| Conduction anesthesia | D000765 | — | — | — | — | — | — | 1 | 1 |
| Hysterectomy | D007044 | EFO_0003881 | — | — | — | — | — | 1 | 1 |
| Electroencephalography | D004569 | — | — | — | — | — | — | 1 | 1 |
| Sleep | D012890 | GO_0030431 | — | — | — | — | — | 1 | 1 |
Show 18 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Neostigmine |
| INN | neostigmine bromide |
| Description | Neostigmine is a quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an antidote to curare poisoning. |
| Classification | Small molecule |
| Drug class | cholinesterase inhibitors (physostigmine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)C(=O)Oc1cccc([N+](C)(C)C)c1 |
Identifiers
| PDB | — |
| CAS-ID | 59-99-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL278020 |
| ChEBI ID | 7514 |
| PubChem CID | 4456 |
| DrugBank | DB01400 |
| UNII ID | 005SYP50G5 (ChemIDplus, GSRS) |
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Bloxiverz – Avadel Pharmaceuticals
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Estimated US medical usage
Neostigmine
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Trends
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Safety
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606 adverse events reported
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