Naloxegol
Movantik, Moventig (naloxegol) is a small molecule pharmaceutical. Naloxegol was first approved as Movantik on 2014-09-16. It is used to treat constipation in the USA. It has been approved in Europe to treat constipation and opioid-related disorders.
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Brand Name | Status | Last Update |
|---|---|---|
| movantik | New Drug Application | 2024-12-19 |
Indications
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Clinical
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43 clinical trials
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Indications Phases 4
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Constipation | D003248 | — | K59.0 | 1 | — | — | — | 4 | 5 |
| Digestive signs and symptoms | D012817 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Opioid-induced constipation | D000079689 | — | — | — | — | — | — | 4 | 4 |
| Cancer pain | D000072716 | — | G89.3 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Naloxegol |
| INN | naloxegol |
| Description | Naloxegol is an organic heteropentacyclic compound that is naloxone in which the keto group is replaced by a PEG moiety. Used for treatment of opioid-induced constipation. It has a role as a mu-opioid receptor antagonist and a cathartic. It is an organic heteropentacyclic compound, a member of phenols, an aromatic ether, a tertiary alcohol and a polyether. It is functionally related to a naloxone. It derives from a hydride of a morphinan. |
| Classification | Small molecule |
| Drug class | narcotic agonists/antagonists (normorphine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=CCN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](OCCOCCOCCOCCOCCOCCOCCOC)CC[C@@]3(O)[C@H]1C5 |
Identifiers
| PDB | — |
| CAS-ID | 854601-70-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2219418 |
| ChEBI ID | 82975 |
| PubChem CID | 56959087 |
| DrugBank | — |
| UNII ID | 44T7335BKE (ChemIDplus, GSRS) |
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Movantik – RedHill Biopharma
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Movantik – AstraZeneca
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2,290 adverse events reported
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