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Drug ReportsNadolol
Nadolol
Corzide, Nadolol (nadolol) is a small molecule pharmaceutical. Nadolol was first approved as Corgard on 1982-01-01. It is used to treat angina pectoris, heart failure, hypertension, and myocardial infarction in the USA. The pharmaceutical is active against beta-2 adrenergic receptor and beta-1 adrenergic receptor. In addition, it is known to target beta-3 adrenergic receptor.
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Drug
Target
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Events Timeline
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3M
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Nadolol (discontinued: Corgard, Nadolol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bendroflumethiazide
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Nadolol
Tradename
Company
Number
Date
Products
CORZIDEKing PharmaceuticalsN-018647 DISCN1983-05-25
2 products, RLD
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Nadolol
Tradename
Company
Number
Date
Products
CORGARDUS WorldMedsN-018063 DISCN1982-01-01
5 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
nadololANDA2024-12-23
nadolol and bendroflumethiazideANDA2016-04-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
heart failureHP_0001635D006333I50
hypertensionEFO_0000537D006973I10
myocardial infarctionEFO_0000612D009203I21
angina pectorisEFO_0003913D000787I20
nephrotic syndromeEFO_0004255D009404N04
edemaHP_0000969D004487R60.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AA: Beta blocking agents, non-selective
— C07AA12: Nadolol
— C07B: Beta blocking agents and thiazides
— C07BA: Beta blocking agents, non-selective, and thiazides
— C07BA12: Nadolol and thiazides
HCPCS
No data
Clinical
Clinical Trials
27 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I101————1
Migraine disordersD008881EFO_0003821G431————1
HeadacheD006261HP_0002315R511————1
Chest painD002637HP_0100749R07.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNadolol
INNnadolol
Description
Nadolol, sold under the brand name Corgard among others, is a medication used to treat high blood pressure, heart pain, atrial fibrillation, and some inherited arrhythmic syndromes. It has also been used to prevent migraine headaches and complications of cirrhosis. It is taken orally.
Classification
Small molecule
Drug classanalgesics (mixed opiate receptor agonists/antagonists); beta-blockers (propranolol type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C)NCC(O)COc1cccc2c1C[C@H](O)[C@H](O)C2
Identifiers
PDB—
CAS-ID42200-33-9
RxCUI—
ChEMBL IDCHEMBL649
ChEBI ID—
PubChem CID39147
DrugBankDB01203
UNII IDFEN504330V (ChemIDplus, GSRS)
Target
Agency Approved
ADRB2
ADRB2
ADRB1
ADRB1
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
154
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Q9UMZ5
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Alternate
ADRB3
ADRB3
Organism
Homo sapiens
Gene name
ADRB3
Gene synonyms
ADRB3R, B3AR
NCBI Gene ID
155
Protein name
beta-3 adrenergic receptor
Protein synonyms
adrenergic, beta-3-, receptor, Beta-3 adrenoceptor, Beta-3 adrenoreceptor
Uniprot ID
Q4JFT4
Mouse ortholog
Adrb3 (11556)
beta-3 adrenergic receptor (Q9QZ98)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Nadolol
+
Bendroflumethiazide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Nadolol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,873 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,353 adverse events reported
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