Muromonab-cd3
Muromonab-cd3 is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against T-cell surface glycoprotein CD3 epsilon chain.
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2Y
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FDA approval date
EMA approval date
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Study first post date
Last update post date
Start date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| immune system diseases | D007154 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J7505 | Muromonab-cd3, parenteral, 5 mg |
Clinical
Clinical Trials
200 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 16 | 21 | 7 | — | — | 38 |
| Leukemia | D007938 | — | C95 | 7 | 21 | 8 | — | — | 32 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 3 | 15 | 8 | — | — | 25 |
| Lymphoid leukemia | D007945 | — | C91 | 5 | 13 | 7 | — | — | 23 |
| Neoplasms | D009369 | — | C80 | 15 | 9 | 1 | — | — | 20 |
| Multiple myeloma | D009101 | — | C90.0 | 13 | 9 | 1 | — | — | 17 |
| Plasma cell neoplasms | D054219 | — | — | 13 | 9 | 1 | — | — | 17 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 7 | 9 | 2 | — | — | 17 |
| B-cell lymphoma | D016393 | — | — | 6 | 9 | 2 | — | — | 15 |
| Follicular lymphoma | D008224 | — | C82 | 3 | 7 | 4 | — | — | 13 |
Show 23 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 6 | 8 | — | — | — | 13 |
| Recurrence | D012008 | — | — | 7 | 4 | — | — | — | 10 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 7 | 4 | — | — | — | 8 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 5 | 3 | — | — | — | 8 |
| Lung neoplasms | D008175 | — | C34.90 | 4 | 2 | — | — | — | 6 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 3 | 3 | — | — | — | 6 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 4 | 2 | — | — | — | 5 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 3 | 4 | — | — | — | 5 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 2 | 3 | — | — | — | 5 |
| Adenocarcinoma | D000230 | — | — | 1 | 5 | — | — | — | 5 |
Show 64 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | 6 | — | — | — | — | 6 |
| Head and neck neoplasms | D006258 | — | — | 3 | — | — | — | — | 3 |
| Acute disease | D000208 | — | — | 2 | — | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | — | — | — | — | 2 |
| Uterine cervical neoplasms | D002583 | — | — | 2 | — | — | — | — | 2 |
| Osteosarcoma | D012516 | — | — | 2 | — | — | — | — | 2 |
| Soft tissue neoplasms | D012983 | — | — | 2 | — | — | — | — | 2 |
| Female genital neoplasms | D005833 | — | — | 2 | — | — | — | — | 2 |
| Mediastinal neoplasms | D008479 | — | C38.3 | 1 | — | — | — | — | 1 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | — | — | — | — | 1 |
Show 22 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | — | 1 | 1 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | — | — | — | 1 | 1 |
| Aplastic anemia | D000741 | — | D61.9 | — | — | — | — | 1 | 1 |
| Diamond-blackfan anemia | D029503 | EFO_0004130 | D61.01 | — | — | — | — | 1 | 1 |
| Cytopenia | D000095542 | — | — | — | — | — | — | 1 | 1 |
| Osteopetrosis | D010022 | — | Q78.2 | — | — | — | — | 1 | 1 |
| Hemophilia b | D002836 | — | D67 | — | — | — | — | 1 | 1 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | — | — | — | 1 | 1 |
| Embolism | D004617 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Muromonab-cd3 |
| INN | muromonab-cd3 |
| Description | Muromonab-CD3 (mouse mab) |
| Classification | Antibody |
| Drug class | cannabinol derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201608 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00075 |
| UNII ID | JGA39ICE2V (ChemIDplus, GSRS) |
Target
Agency Approved
CD3E
CD3E
Organism
Homo sapiens
Gene name
CD3E
Gene synonyms
T3E
NCBI Gene ID
Protein name
T-cell surface glycoprotein CD3 epsilon chain
Protein synonyms
CD3-epsilon, CD3e, CD3e antigen, epsilon polypeptide (TiT3 complex), CD3e molecule, epsilon (CD3-TCR complex), T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain
Uniprot ID
Mouse ortholog
Cd3e (12501)
T-cell surface glycoprotein CD3 epsilon chain (P22646)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,891 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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300 adverse events reported
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