Monalizumab
Monalizumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against NKG2-A/NKG2-B type II integral membrane protein.
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Commercial
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Clinical
Clinical Trials
21 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 5 | 1 | — | — | 7 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 4 | 1 | — | — | 6 |
| Squamous cell carcinoma | D002294 | — | — | 3 | 4 | 1 | — | — | 5 |
| Carcinoma | D002277 | — | C80.0 | 2 | 2 | 1 | — | — | 4 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 2 | 3 | 1 | — | — | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | 2 | — | — | — | 3 |
| Colorectal neoplasms | D015179 | — | — | — | 2 | — | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 2 | — | — | — | 2 |
| Head and neck neoplasms | D006258 | — | — | 1 | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | 1 | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 1 | — | — | — | 1 |
| Lymphoid leukemia | D007945 | — | C91 | 1 | 1 | — | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Female genital neoplasms | D005833 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Monalizumab |
| INN | monalizumab |
| Description | Monalizumab, a humanized anti-NKG2A antibody(formerly IPH2201) is an investigational drug being studied for rheumatoid arthritis, gynecologic malignancies and other cancers.
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| Classification | Antibody |
| Drug class | monoclonal antibodies; narcotic agonists/antagonists (normorphine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297787 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 3ZXZ2V0588 (ChemIDplus, GSRS) |
Target
Agency Approved
KLRC1
KLRC1
Organism
Homo sapiens
Gene name
KLRC1
Gene synonyms
NKG2A
NCBI Gene ID
Protein name
NKG2-A/NKG2-B type II integral membrane protein
Protein synonyms
C-lectin type II protein, CD159 antigen-like family member A, CD159a, killer cell lectin-like receptor subfamily C, member 1, natural killer cell lectin, natural killer group protein 2, NK cell receptor A, NKG2-1/B activating NK receptor, NKG2-A/B type II integral membrane protein, NKG2-A/B-activating NK receptor
Uniprot ID
Mouse ortholog
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Alternate
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Variants
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Trends
PubMed Central
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Safety
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Adverse Events
Top Adverse Reactions
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16 adverse events reported
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