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Drug ReportsMetoprolol
Metoprolol
Dutoprol, Kapspargo, Lopressidone, Lopressor, Metoprolol, Toprol-xl (metoprolol) is a small molecule pharmaceutical. Metoprolol was first approved as Lopressor on 1982-01-01. It is used to treat angina pectoris, atrial fibrillation, atrial flutter, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target beta-2 adrenergic receptor.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
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Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Kapspargo, Lopressor, Metoprolol, Toprol-xl (discontinued: Lopressor, Metoprolol)
Combinations
Lopressor, Metoprolol hydrochlorothiazide (discontinued: Dutoprol, Lopressidone, Lopressor, Metoprolol hydrochlorothiazide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorthalidone
+
Metoprolol tartrate
Tradename
Company
Number
Date
Products
LOPRESSIDONENovartisN-019451 DISCN1987-12-31
2 products
Hide discontinued
Metoprolol tartrate
Tradename
Company
Number
Date
Products
LOPRESSORValidus PharmaceuticalsN-017963 RX1982-01-01
2 products, RLD
Show 1 discontinued
Metoprolol fumarate
Tradename
Company
Number
Date
Products
LOPRESSORNovartisN-019786 DISCN1989-12-27
4 products
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Metoprolol succinate
Tradename
Company
Number
Date
Products
KAPSPARGO SPRINKLESun PharmaceuticalsN-210428 RX2018-01-26
4 products, RLD, RS
TOPROL-XLToprol AcquisitionN-019962 RX1992-01-10
4 products, RLD, RS
Hydrochlorothiazide
+
Metoprolol tartrate
Tradename
Company
Number
Date
Products
LOPRESSOR HCTValidus PharmaceuticalsN-018303 RX1984-12-31
1 products, RLD
Show 1 discontinued
Hydrochlorothiazide
+
Metoprolol succinate
Tradename
Company
Number
Date
Products
DUTOPROLConcordia LaboratoriesN-021956 DISCN2006-08-28
3 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
hypertensololunapproved drug other2011-08-01
kapspargoNew Drug Application2023-04-12
lopressorNew Drug Application2023-09-14
lopressor hctNew Drug Application2023-09-13
metoprololANDA2024-05-30
metoprolol succinateANDA2024-12-03
metoprolol succinate erANDA2024-04-11
metoprolol succinate metoprolol succinate erANDA2024-01-10
metoprolol succinate metoprolol tartrateANDA2024-01-09
metoprolol tartateANDA2015-04-01
Show 7 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
atrial fibrillationEFO_0000275D001281I48.0
heart failureHP_0001635D006333I50
hypertensionEFO_0000537D006973I10
myocardial infarctionEFO_0000612D009203I21
angina pectorisEFO_0003913D000787I20
atrial flutterEFO_0003911D001282—
ventricular tachycardia—D017180I47.2
ventricular fibrillationHP_0001663D014693I49.01
supraventricular tachycardiaHP_0004755D013617I47.1
nephrotic syndromeEFO_0004255D009404N04
Show 3 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Metoprolol Succinate, Kapspargo Sprinkle, Spil
95046552035-07-09DP
97005302035-07-09DP
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AB: Beta blocking agents, selective
— C07AB02: Metoprolol
— C07B: Beta blocking agents and thiazides
— C07BB: Beta blocking agents, selective, and thiazides
— C07BB02: Metoprolol and thiazides
— C07BB52: Metoprolol and thiazides, combinations
— C07C: Beta blocking agents and other diuretics
— C07CB: Beta blocking agents, selective, and other diuretics
— C07CB02: Metoprolol and other diuretics
— C07F: Beta blocking agents, other combinations
— C07FB: Beta blocking agents and calcium channel blockers
— C07FB02: Metoprolol and felodipine
— C07FB13: Metoprolol and amlodipine
— C07FX: Beta blocking agents, other combinations
— C07FX03: Metoprolol and acetylsalicylic acid
— C07FX05: Metoprolol and ivabradine
HCPCS
No data
Clinical
Clinical Trials
318 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10——2——2
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———4————4
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMetoprolol
INNmetoprolol
Description
Metoprolol is a propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, a xenobiotic, an environmental contaminant and a geroprotector. It is a propanolamine, an aromatic ether, a secondary alcohol and a secondary amino compound.
Classification
Small molecule
Drug classbeta-blockers (propranolol type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COCCc1ccc(OCC(O)CNC(C)C)cc1
Identifiers
PDB—
CAS-ID37350-58-6
RxCUI—
ChEMBL IDCHEMBL13
ChEBI ID6904
PubChem CID4171
DrugBankDB00264
UNII IDGEB06NHM23 (ChemIDplus, GSRS)
Target
Agency Approved
ADRB1
ADRB1
Organism
Homo sapiens
Gene name
ADRB1
Gene synonyms
ADRB1R, B1AR
NCBI Gene ID
153
Protein name
beta-1 adrenergic receptor
Protein synonyms
adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Uniprot ID
Q9UKG8
Mouse ortholog
Adrb1 (11554)
beta-1 adrenergic receptor (P34971)
Alternate
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
154
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Q9UMZ5
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Metoprolol
+
Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Metoprolol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 25,077 documents
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Safety
Black-box Warning
Black-box warning for: Hypertensolol, Metoprolol succinate metoprolol succinate er
Adverse Events
Top Adverse Reactions
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53,869 adverse events reported
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