Metoprolol
Dutoprol, Kapspargo, Lopressidone, Lopressor, Metoprolol, Toprol-xl (metoprolol) is a small molecule pharmaceutical. Metoprolol was first approved as Lopressor on 1982-01-01. It is used to treat angina pectoris, atrial fibrillation, atrial flutter, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target beta-2 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Kapspargo, Lopressor, Metoprolol, Toprol-xl (discontinued: Lopressor, Metoprolol)
CombinationsLopressor, Metoprolol hydrochlorothiazide (discontinued: Dutoprol, Lopressidone, Lopressor, Metoprolol hydrochlorothiazide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorthalidone
+
Metoprolol tartrate
Metoprolol tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOPRESSOR | Validus Pharmaceuticals | N-017963 RX | 1982-01-01 | 2 products, RLD |
Show 1 discontinued
Metoprolol fumarate
Metoprolol succinate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| KAPSPARGO SPRINKLE | Sun Pharmaceuticals | N-210428 RX | 2018-01-26 | 4 products, RLD, RS |
| TOPROL-XL | Toprol Acquisition | N-019962 RX | 1992-01-10 | 4 products, RLD, RS |
Hydrochlorothiazide
+
Metoprolol tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOPRESSOR HCT | Validus Pharmaceuticals | N-018303 RX | 1984-12-31 | 1 products, RLD |
Show 1 discontinued
Hydrochlorothiazide
+
Metoprolol succinate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUTOPROL | Concordia Laboratories | N-021956 DISCN | 2006-08-28 | 3 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| hypertensolol | unapproved drug other | 2011-08-01 |
| kapspargo | New Drug Application | 2023-04-12 |
| lopressor | New Drug Application | 2025-04-18 |
| lopressor hct | New Drug Application | 2023-09-13 |
| metoprolol | ANDA | 2025-01-15 |
| metoprolol succinate | ANDA | 2025-04-30 |
| metoprolol succinate er | ANDA | 2024-04-11 |
| metoprolol succinate metoprolol succinate er | ANDA | 2024-01-10 |
| metoprolol succinate metoprolol tartrate | ANDA | 2024-01-09 |
| metoprolol tartate | ANDA | 2015-04-01 |
Show 7 more
Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AB: Beta blocking agents, selective
— C07AB02: Metoprolol
— C07B: Beta blocking agents and thiazides
— C07BB: Beta blocking agents, selective, and thiazides
— C07BB02: Metoprolol and thiazides
— C07BB52: Metoprolol and thiazides, combinations
— C07C: Beta blocking agents and other diuretics
— C07CB: Beta blocking agents, selective, and other diuretics
— C07CB02: Metoprolol and other diuretics
— C07F: Beta blocking agents, other combinations
— C07FB: Beta blocking agents and calcium channel blockers
— C07FB02: Metoprolol and felodipine
— C07FB13: Metoprolol and amlodipine
— C07FX: Beta blocking agents, other combinations
— C07FX03: Metoprolol and acetylsalicylic acid
— C07FX05: Metoprolol and ivabradine
HCPCS
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Clinical
Clinical Trials
325 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 3 | 9 | 20 | 33 | 16 | 76 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 5 | 7 | 15 | 11 | 38 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 2 | 2 | 5 | 10 | 12 | 30 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | — | 6 | 12 | 19 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | 1 | 4 | 4 | 6 | 1 | 14 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | 2 | 2 | 8 | 1 | 13 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | 3 | 10 | 13 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | 2 | 2 | 7 | 2 | 13 |
| Coronary disease | D003327 | — | — | — | — | 1 | 4 | 7 | 12 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 3 | 1 | 1 | 5 | 1 | 11 |
Show 88 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | 3 | — | 1 | 5 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 2 | 1 | — | 1 | 4 |
| Burns | D002056 | — | T30.0 | — | 4 | 4 | — | — | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | 3 | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 1 | — | 1 | 3 |
| Renal insufficiency | D051437 | — | N19 | — | 1 | 1 | — | 1 | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | 1 | — | 1 | 3 |
| Fibrosis | D005355 | — | — | — | 1 | 1 | — | 1 | 3 |
| Lung neoplasms | D008175 | — | C34.90 | — | — | 2 | — | — | 2 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | 1 | — | 1 | 2 |
Show 28 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 20 | 1 | — | — | — | 21 |
| Tachycardia | D013610 | — | R00.0 | 1 | 2 | — | — | 4 | 7 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 4 | 1 | — | — | — | 5 |
| Dermatitis | D003872 | — | L30.9 | 4 | 1 | — | — | — | 5 |
| Eczema | D004485 | — | L30.9 | 3 | 1 | — | — | — | 4 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 2 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | — | 2 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | — | 1 | — | — | 1 | 2 |
| Wounds and injuries | D014947 | — | T14.8 | — | 2 | — | — | — | 2 |
| Prader-willi syndrome | D011218 | Orphanet_739 | Q87.11 | — | 2 | — | — | — | 2 |
Show 17 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | 1 | 3 |
| Drug interactions | D004347 | — | — | 2 | — | — | — | 1 | 3 |
| Covid-19 | D000086382 | — | U07.1 | 1 | — | — | — | 1 | 2 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | 1 | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | — | — | — | — | 2 |
| Fasting | D005215 | EFO_0002756 | — | 2 | — | — | — | — | 2 |
| Malaria | D008288 | EFO_0001068 | B54 | 1 | — | — | — | — | 1 |
| Hepatitis c | D006526 | — | B19.2 | 1 | — | — | — | — | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | 1 | — | — | — | — | 1 |
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | — | — | — | — | 1 |
Show 8 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Percutaneous coronary intervention | D062645 | — | — | — | — | — | — | 2 | 2 |
| Kidney transplantation | D016030 | — | — | — | — | — | — | 2 | 2 |
| Cerebral hemorrhage | D002543 | — | — | — | — | — | — | 2 | 2 |
| Chest pain | D002637 | — | R07.9 | — | — | — | — | 2 | 2 |
| Coronary occlusion | D054059 | — | I21 | — | — | — | — | 1 | 1 |
| Drug-eluting stents | D054855 | — | — | — | — | — | — | 1 | 1 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | — | 1 | 1 |
| Vomiting | D014839 | — | R11.1 | — | — | — | — | 1 | 1 |
| Nausea | D009325 | — | R11.0 | — | — | — | — | 1 | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 1 | 1 |
Show 16 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Metoprolol |
| INN | metoprolol |
| Description | Metoprolol is a propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, a xenobiotic, an environmental contaminant and a geroprotector. It is a propanolamine, an aromatic ether, a secondary alcohol and a secondary amino compound. |
| Classification | Small molecule |
| Drug class | beta-blockers (propranolol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COCCc1ccc(OCC(O)CNC(C)C)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 37350-58-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL13 |
| ChEBI ID | 6904 |
| PubChem CID | 4171 |
| DrugBank | DB00264 |
| UNII ID | GEB06NHM23 (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Metoprolol
+
Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Metoprolol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 26,233 documents
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Safety
Black-box Warning
Black-box warning for: Hypertensolol, Metoprolol succinate metoprolol succinate er
Adverse Events
Top Adverse Reactions
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56,007 adverse events reported
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