Methylprednisolone
Depo-medrol, Medrol, Methylprednisolone, Neo-medrol, Solu-medrol (methylprednisolone) is a small molecule pharmaceutical. Methylprednisolone was first approved as Medrol on 1982-01-01. It is used to treat adrenal insufficiency, ankylosing spondylitis, asthma, atopic dermatitis, and berylliosis amongst others in the USA. The pharmaceutical is active against glucocorticoid receptor. In addition, it is known to target short transient receptor potential channel 5.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Depo-medrol, Medrol, Methylprednisolone, Solu-medrol (discontinued: A-methapred, M-predrol, Medrol, Methylprednisolone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methylprednisolone acetate
Methylprednisolone
Methylprednisolone sodium succinate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SOLU-MEDROL | Pharmacia & Upjohn | N-011856 RX | 1982-01-01 | 5 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| depo-medrol | New Drug Application | 2024-07-24 |
| dyural 40 kit | unapproved drug other | 2024-10-05 |
| dyural 80 kit | unapproved drug other | 2024-10-05 |
| dyural 80-lm | unapproved drug other | 2024-10-05 |
| dyural l kit | unapproved drug other | 2024-10-05 |
| dyural lm kit | unapproved drug other | 2024-10-05 |
| hybrisil | unapproved drug other | 2011-04-22 |
| medrol | New Drug Application | 2024-07-18 |
| medroloan ii suik | unapproved drug other | 2022-12-09 |
| medroloan suik | unapproved drug other | 2022-12-09 |
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
D: Dermatologicals
— D07: Corticosteroids, dermatological preparations
— D07A: Corticosteroid dermatological preparations, plain
— D07AA: Corticosteroids, weak (group i)
— D07AA01: Methylprednisolone
— D07AC: Corticosteroids, potent (group iii)
— D07AC14: Methylprednisolone aceponate
— D07C: Corticosteroids, combinations with antibiotics
— D07CA: Corticosteroids, weak, combinations with antibiotics
— D07CA02: Methylprednisolone and antibiotics
— D10: Anti-acne preparations
— D10A: Anti-acne preparations for topical use
— D10AA: Corticosteroids, combinations for treatment of acne
— D10AA02: Methylprednisolone
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H02: Corticosteroids for systemic use
— H02A: Corticosteroids for systemic use, plain
— H02AB: Glucocorticoids, systemic
— H02AB04: Methylprednisolone
— H02B: Corticosteroids for systemic use, combinations
— H02BX: Corticosteroids for systemic use, combinations
— H02BX01: Methylprednisolone, combinations
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01C: Antiinflammatory agents and antiinfectives in combination
— S01CA: Corticosteroids and antiinfectives in combination, opthalmologic
— S01CA08: Methylprednisolone and antiinfectives
— S03: Ophthalmological and otological preparations
— S03C: Corticosteroids and antiinfectives in combination, opthalmologic and otologic
— S03CA: Corticosteroids and antiinfectives in combination
— S03CA07: Methylprednisolone and antiinfectives
HCPCS
Code | Description |
|---|---|
| J1020 | Injection, methylprednisolone acetate, 20 mg |
| J1030 | Injection, methylprednisolone acetate, 40 mg |
| J1040 | Injection, methylprednisolone acetate, 80 mg |
| J2920 | Injection, methylprednisolone sodium succinate, up to 40 mg |
| J2930 | Injection, methylprednisolone sodium succinate, up to 125 mg |
| J7509 | Methylprednisolone oral, per 4 mg |
Clinical
Clinical Trials
2097 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 36 | 107 | 57 | 6 | 16 | 200 |
| Leukemia | D007938 | — | C95 | 21 | 80 | 28 | 7 | 11 | 130 |
| Syndrome | D013577 | — | — | 17 | 54 | 25 | 17 | 22 | 122 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 7 | 40 | 26 | 9 | 5 | 78 |
| Prostatic neoplasms | D011471 | — | C61 | 12 | 33 | 25 | 6 | 8 | 77 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 3 | 19 | 22 | 19 | 8 | 69 |
| Lymphoid leukemia | D007945 | — | C91 | 8 | 37 | 19 | 7 | 4 | 69 |
| Kidney transplantation | D016030 | — | — | 5 | 19 | 14 | 20 | 3 | 56 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 3 | 17 | 16 | 16 | 5 | 56 |
| Covid-19 | D000086382 | — | — | 2 | 10 | 23 | 7 | 17 | 55 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Graft vs host disease | D006086 | — | D89.81 | 15 | 36 | 16 | — | 7 | 66 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 11 | 34 | 17 | — | 4 | 59 |
| Myelodysplastic syndromes | D009190 | — | D46 | 10 | 39 | 2 | — | 4 | 49 |
| Multiple myeloma | D009101 | — | C90.0 | 10 | 21 | 8 | — | 6 | 44 |
| Preleukemia | D011289 | — | — | 9 | 32 | 2 | — | 4 | 42 |
| Plasma cell neoplasms | D054219 | — | — | 8 | 18 | 8 | — | 6 | 40 |
| Alcoholic hepatitis | D006519 | EFO_1001345 | K70.1 | 1 | 6 | 7 | — | 6 | 19 |
| Plasmacytoma | D010954 | — | C90.3 | 3 | 9 | 2 | — | 4 | 18 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 7 | 15 | 2 | — | — | 18 |
| Myeloid leukemia | D007951 | — | C92 | 6 | 14 | 2 | — | — | 17 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloproliferative disorders | D009196 | — | D47.1 | 5 | 17 | — | — | 2 | 22 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 1 | 11 | — | — | 2 | 14 |
| T-cell lymphoma | D016399 | — | — | 5 | 9 | — | — | — | 11 |
| T-cell lymphoma peripheral | D016411 | — | — | 4 | 7 | — | — | — | 8 |
| Fanconi anemia | D005199 | Orphanet_84 | D61.09 | 3 | 6 | — | — | 1 | 8 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 7 | — | — | — | 7 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | 2 | 2 | — | — | 3 | 6 |
| Necrosis | D009336 | — | — | — | 5 | — | — | 1 | 6 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | 5 | — | — | — | 6 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 3 | 5 | — | — | — | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pathologic dilatation | D004108 | — | — | 1 | — | — | — | 4 | 5 |
| Intestinal diseases | D007410 | HP_0002242 | K63.9 | 1 | — | — | — | 2 | 3 |
| Therapeutic equivalency | D013810 | — | — | 3 | — | — | — | — | 3 |
| Precancerous conditions | D011230 | — | — | 2 | — | — | — | — | 2 |
| Ataxia | D001259 | — | R27.0 | 2 | — | — | — | — | 2 |
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | 2 | — | — | — | — | 2 |
| Cerebellar ataxia | D002524 | HP_0001251 | — | 2 | — | — | — | — | 2 |
| Retinal perforations | D012167 | EFO_1001028 | — | 1 | — | — | — | 1 | 2 |
| Tinnitus | D014012 | HP_0000360 | H93.1 | 1 | — | — | — | 1 | 2 |
| Blister | D001768 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 3 | 3 |
| Rotator cuff injuries | D000070636 | — | M75.1 | — | — | — | — | 3 | 3 |
| Regeneration | D012038 | — | — | — | — | — | — | 3 | 3 |
| Granulomatous mastitis | D058890 | — | N61.2 | — | — | — | — | 2 | 2 |
| Mastitis | D008413 | EFO_1001034 | N61 | — | — | — | — | 2 | 2 |
| Keratoconjunctivitis | D007637 | — | H16.2 | — | — | — | — | 2 | 2 |
| Blood pressure | D001794 | EFO_0004325 | — | — | — | — | — | 2 | 2 |
| Muscle cramp | D009120 | HP_0003394 | — | — | — | — | — | 2 | 2 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | — | 2 | 2 |
| Vitiligo | D014820 | EFO_0004208 | L80 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methylprednisolone |
| INN | methylprednisolone |
| Description | 6alpha-methylprednisolone is the 6alpha-stereoisomer of 6-methylprednisolone. It has a role as an anti-inflammatory drug, a neuroprotective agent, an antiemetic, an adrenergic agent, a xenobiotic and an environmental contaminant. It is a 6-methylprednisolone, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. |
| Classification | Small molecule |
| Drug class | steroids (not prednisolone derivatives); prednisone and prednisolone derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]2(C)C=CC(=O)C=C12 |
Identifiers
| PDB | — |
| CAS-ID | 83-43-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL650 |
| ChEBI ID | 6888 |
| PubChem CID | 6741 |
| DrugBank | DB00959 |
| UNII ID | X4W7ZR7023 (ChemIDplus, GSRS) |
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
TRPC5
TRPC5
Organism
Homo sapiens
Gene name
TRPC5
Gene synonyms
TRP5
NCBI Gene ID
Protein name
short transient receptor potential channel 5
Protein synonyms
hTRP-5, hTRP5, protein phosphatase 1, regulatory subunit 159, transient receptor potential channel 5, Transient receptor protein 5, TRP-5
Uniprot ID
Mouse ortholog
Trpc5 (22067)
short transient receptor potential channel 5 (Q9R0D4)
Variants
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Financial
Revenue by drug
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Medrol – Pfizer
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Estimated US medical usage
Methylprednisolone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 73,891 documents
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Safety
Black-box Warning
Black-box warning for: Dyural 40 kit, Dyural 80 kit, Dyural 80-lm, Dyural lm kit, Physicians ez use m-pred
Adverse Events
Top Adverse Reactions
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68,475 adverse events reported
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