Relistor(methylnaltrexone)
Methylnaltrexone, Relistor (methylnaltrexone) is a small molecule pharmaceutical. Methylnaltrexone was first approved as Relistor on 2008-04-24. It is used to treat constipation in the USA. It has been approved in Europe to treat constipation and opioid-related disorders. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target kappa-type opioid receptor and delta-type opioid receptor.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Methylnaltrexone, Relistor
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methylnaltrexone bromide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RELISTOR | Salix Pharmaceuticals | N-208271 RX | 2016-07-19 | 1 products, RLD, RS |
| RELISTOR | Salix Pharmaceuticals | N-021964 RX | 2008-04-24 | 3 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| relistor | New Drug Application | 2024-05-14 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| constipation | — | D003248 | K59.0 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Methylnaltrexone Bromide, Relistor, Salix | |||
| 8524276 | 2031-03-10 | DP | |
| 8956651 | 2031-03-10 | DP | |
| 9314461 | 2031-03-10 | DP | |
| 10307417 | 2031-03-10 | DP | |
| 10376505 | 2031-03-10 | DP | |
| 8420663 | 2029-09-30 | U-1185 | |
| 9180125 | 2029-09-30 | DP | U-1185 |
| 9492445 | 2029-09-30 | DP | U-1185 |
| 9724343 | 2029-09-30 | DP | U-1185 |
| Methylnaltrexone Bromide, Relistor, Salix Pharms | |||
| 8247425 | 2030-12-31 | U-1185 | |
| 8822490 | 2029-09-30 | DP | U-1185 |
| 8552025 | 2024-04-08 | DP | |
| 9669096 | 2024-04-08 | DP | |
| 10376584 | 2024-04-08 | DP | U-1185 |
HCPCS
Code | Description |
|---|---|
| J2212 | Injection, methylnaltrexone, 0.1 mg |
Clinical
Clinical Trials
59 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Constipation | D003248 | — | K59.0 | — | 2 | 6 | 3 | 1 | 12 |
| Opioid-induced constipation | D000079689 | — | — | — | 2 | 5 | 3 | 1 | 11 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ileus | D045823 | — | K56.7 | — | 1 | 2 | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | 2 | — | — | 2 |
| Intestinal diseases | D007410 | — | K63.9 | — | 1 | 1 | — | — | 2 |
| Ventral hernia | D006555 | EFO_1001866 | K43 | — | — | 1 | — | — | 1 |
| Hernia | D006547 | — | K40-K46 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | 1 | — | — | — | 5 |
| Gastrointestinal diseases | D005767 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Methylnaltrexone |
| INN | methylnaltrexone bromide |
| Description | Methylnaltrexone is a member of phenanthrenes. |
| Classification | Small molecule |
| Drug class | narcotic agonists/antagonists (normorphine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[N+]1(CC2CC2)CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5 |
Identifiers
| PDB | — |
| CAS-ID | 83387-25-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1186579 |
| ChEBI ID | — |
| PubChem CID | 5361918 |
| DrugBank | DB06800 |
| UNII ID | RFO6IL3D3M (ChemIDplus, GSRS) |
Target
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 904 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
1,069 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use