Meperidine
Demerol, Mepergan, Meperidine (meperidine) is a small molecule pharmaceutical. Meperidine was first approved as Meperidine and atropine sulfate on 1982-01-01. It is used to treat pain in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target kappa-type opioid receptor and delta-type opioid receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Demerol, Meperidine (discontinued: Demerol, Meperidine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Meperidine hydrochloride
Meperidine hydrochloride
+
Promethazine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MEPERGAN | Hikma Pharmaceuticals | N-011730 DISCN | 1982-01-01 | 1 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| demerol | New Drug Application | 2024-12-12 |
| meperidine hcl | unapproved drug other | 2014-08-13 |
| meperidine hydrochloride | ANDA | 2024-12-19 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
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ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AB: Phenylpiperidine derivatives, opioid analgesics
— N02AB02: Pethidine
— N02AB52: Pethidine, combinations excl. psycholeptics
— N02AB72: Pethidine, combinations with psycholeptics
— N02AG: Opioids in combination with antispasmodics
— N02AG03: Pethidine and antispasmodics
Clinical
Clinical Trials
169 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 1 | — | — | 5 | 18 | 24 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 1 | 5 | 5 | 11 |
| Labor pain | D048949 | — | — | — | 1 | 1 | 3 | 5 | 9 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | 1 | 7 | 8 |
| Analgesia | D000698 | — | — | — | 1 | — | 3 | 3 | 7 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | 1 | 1 | 3 |
| Endoscopic retrograde cholangiopancreatography | D002760 | — | — | — | — | — | 1 | 2 | 3 |
| Colonoscopy | D003113 | — | — | — | — | 1 | 1 | 1 | 3 |
| Choledocholithiasis | D042883 | EFO_1000865 | — | — | 1 | — | 1 | 1 | 3 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | — | 1 | 2 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cesarean section | D002585 | — | — | — | — | 1 | — | 5 | 6 |
| Adenoma | D000236 | — | — | — | — | 1 | — | 2 | 3 |
| Obstetrical analgesia | D016362 | — | — | — | 3 | 1 | — | — | 3 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 1 | — | 1 | 2 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 2 | — | — | 2 |
| Phantom limb | D010591 | — | G54.6 | — | 1 | 1 | — | — | 1 |
| Obstetric labor complications | D007744 | — | — | — | — | 1 | — | — | 1 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 1 | 1 | — | — | 1 |
| Obstetrical anesthesia | D000773 | — | — | — | 1 | 1 | — | — | 1 |
| Depression | D003863 | — | F33.9 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | 1 | — | — | 2 | 3 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | 1 | — | — | — | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | — | 1 | 2 |
| Ovarian epithelial carcinoma | D000077216 | — | — | — | 1 | — | — | 1 | 2 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | 1 | — | — | — | 1 |
| Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | 1 | — | — | — | 1 |
| Pathologic dilatation | D004108 | — | — | — | 1 | — | — | — | 1 |
| Acupuncture analgesia | D015667 | — | — | 1 | 1 | — | — | — | 1 |
| Acute kidney injury | D058186 | — | N17 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | — | — | — | — | 4 | 4 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 4 | 4 |
| Replacement arthroplasty knee | D019645 | — | — | — | — | — | — | 3 | 3 |
| Renal insufficiency | D051437 | — | N19 | — | — | — | — | 3 | 3 |
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 3 | 3 |
| Anesthesia | D000758 | — | — | — | — | — | — | 3 | 3 |
| Conduction anesthesia | D000765 | — | — | — | — | — | — | 3 | 3 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 3 | 3 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 2 | 2 |
| Shoulder impingement syndrome | D019534 | EFO_1001178 | M75.4 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Meperidine |
| INN | pethidine |
| Description | Pethidine is a piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain. It has a role as an opioid analgesic, a kappa-opioid receptor agonist, a mu-opioid receptor agonist and an antispasmodic drug. It is an ethyl ester, a piperidinecarboxylate ester and a tertiary amino compound. It is a conjugate base of a pethidine(1+). |
| Classification | Small molecule |
| Drug class | analgesics (meperidine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)C1(c2ccccc2)CCN(C)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 57-42-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL607 |
| ChEBI ID | 6754 |
| PubChem CID | 4058 |
| DrugBank | DB00454 |
| UNII ID | 9E338QE28F (ChemIDplus, GSRS) |
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Estimated US medical usage
Meperidine
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Meperidine
+
Promethazine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
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Additional graphs summarizing 17,427 documents
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Safety
Black-box Warning
Black-box warning for: Demerol, Meperidine hydrochloride
Adverse Events
Top Adverse Reactions
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8,088 adverse events reported
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