Meperidine
Demerol, Mepergan, Meperidine (meperidine) is a small molecule pharmaceutical. Meperidine was first approved as Meperidine and atropine sulfate on 1982-01-01. It is used to treat pain in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target kappa-type opioid receptor and delta-type opioid receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Demerol (generic drugs available since 1982-01-01)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Meperidine hydrochloride
Meperidine hydrochloride
+
Promethazine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MEPERGAN | Hikma Pharmaceuticals | N-011730 DISCN | 1982-01-01 | 1 products |
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FDA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AB: Phenylpiperidine derivatives, opioid analgesics
— N02AB02: Pethidine
— N02AB52: Pethidine, combinations excl. psycholeptics
— N02AB72: Pethidine, combinations with psycholeptics
— N02AG: Opioids in combination with antispasmodics
— N02AG03: Pethidine and antispasmodics
Clinical
Clinical Trials
155 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 1 | 1 | 1 | 3 | 14 | 19 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 1 | 5 | 5 | 11 |
| Labor pain | D048949 | — | — | — | 1 | 1 | 3 | 5 | 9 |
| Analgesia | D000698 | — | — | — | 1 | — | 2 | 2 | 5 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | — | 1 | 3 | 4 |
| Endoscopic retrograde cholangiopancreatography | D002760 | — | — | — | — | — | 1 | 2 | 3 |
| Colonoscopy | D003113 | — | — | — | — | 1 | 1 | 1 | 3 |
| Choledocholithiasis | D042883 | EFO_1000865 | — | — | 1 | — | 1 | 1 | 3 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | 1 | 1 | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obstetrical analgesia | D016362 | — | — | — | 3 | 1 | — | — | 3 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 1 | — | 1 | 2 |
| Phantom limb | D010591 | — | G54.6 | — | 1 | 1 | — | — | 1 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 1 | 1 | — | — | 1 |
| Obstetrical anesthesia | D000773 | — | — | — | 1 | 1 | — | — | 1 |
| Gastric outlet obstruction | D017219 | EFO_1000947 | — | — | — | 1 | — | — | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 1 | — | — | 1 |
| Ischemic stroke | D000083242 | — | — | — | — | 1 | — | — | 1 |
| Sciatica | D012585 | HP_0011868 | M54.3 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Graft vs host disease | D006086 | — | D89.81 | 1 | 1 | — | — | — | 2 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | 1 | — | — | — | 1 |
| Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | 1 | — | — | — | 1 |
| Acupuncture analgesia | D015667 | — | — | 1 | 1 | — | — | — | 1 |
| Cholangitis | D002761 | HP_0030151 | K83.0 | — | 1 | — | — | — | 1 |
| Choledochal cyst | D015529 | — | Q44.4 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cesarean section | D002585 | — | — | — | — | — | — | 5 | 5 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 4 | 4 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 2 | 2 |
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 2 | 2 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 2 | 2 |
| Hip injuries | D025981 | — | — | — | — | — | — | 2 | 2 |
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | — | — | — | — | 2 | 2 |
| Anesthesia | D000758 | — | — | — | — | — | — | 2 | 2 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | — | 1 | 1 |
| Colorectal neoplasms | D015179 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Meperidine |
| INN | pethidine |
| Description | Pethidine is a piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain. It has a role as an opioid analgesic, a kappa-opioid receptor agonist, a mu-opioid receptor agonist and an antispasmodic drug. It is an ethyl ester, a piperidinecarboxylate ester and a tertiary amino compound. It is a conjugate base of a pethidine(1+). |
| Classification | Small molecule |
| Drug class | analgesics (meperidine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)C1(c2ccccc2)CCN(C)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 57-42-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL607 |
| ChEBI ID | 6754 |
| PubChem CID | 4058 |
| DrugBank | DB00454 |
| UNII ID | 9E338QE28F (ChemIDplus, GSRS) |
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Meperidine
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Meperidine
+
Promethazine
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Safety
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6,274 adverse events reported
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