Menthol
Salonpas (menthol) is a small molecule pharmaceutical. Menthol was first approved as Salonpas on 2008-02-20. It is used to treat pain and skin diseases in the USA. The pharmaceutical is active against alpha-1A adrenergic receptor, alpha-2A adrenergic receptor, and transient receptor potential cation channel subfamily M member 8. In addition, it is known to target alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1D, transient receptor potential cation channel subfamily A member 1, alpha-1B adrenergic receptor, 5-hydroxytryptamine receptor 2C, transient receptor potential cation channel subfamily V member 3, alpha-2C adrenergic receptor, and alpha-1D adrenergic receptor.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Combinations
Salonpas
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Menthol
+
Methyl salicylate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SALONPAS | Hisamitsu Pharmaceutical | N-022029 OTC | 2008-02-20 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| air sinsinpas-ex | C200263 | 2024-01-05 |
| antiphlamine | unapproved drug other | 2017-05-11 |
| cool pap cataplasma | OTC monograph not final | 2022-01-17 |
| essentials | OTC monograph not final | 2018-12-21 |
| family care pain relief | OTC monograph not final | 2013-11-26 |
| halls | C200263 | 2024-08-21 |
| halls naturals | OTC monograph final | 2013-08-07 |
| hallsmelon splash | OTC monograph final | 2014-02-04 |
| hallssugar free extra | OTC monograph not final | 2014-02-07 |
| mentholatum | unapproved drug other | 2023-07-06 |
Show 18 more
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
533 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 16 | 12 | 14 | 2 | 15 | 56 |
| Neuralgia | D009437 | EFO_0009430 | — | 3 | 11 | 7 | 6 | 12 | 37 |
| Cough | D003371 | HP_0012735 | R05 | 7 | 5 | 2 | 2 | 14 | 28 |
| Healthy volunteers/patients | — | — | — | 12 | 3 | — | 1 | 12 | 27 |
| Postherpetic neuralgia | D051474 | — | — | 1 | 6 | 5 | 3 | 2 | 15 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 3 | 3 | 6 | 3 | 1 | 15 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 2 | 2 | 6 | 4 | 1 | 14 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | 5 | 6 | 2 | 1 | 12 |
| Rhinitis | D012220 | EFO_0008521 | J31 | 1 | 3 | 1 | 4 | 2 | 11 |
| Syndrome | D013577 | — | — | — | — | — | 2 | 8 | 10 |
Show 52 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tobacco use disorder | D014029 | — | F17 | 11 | 1 | 2 | — | 16 | 29 |
| Tobacco use | D064424 | — | — | 2 | — | 1 | — | 26 | 29 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | 1 | 9 | 12 | — | 6 | 25 |
| Vaping | D000072137 | — | — | — | — | 1 | — | 20 | 21 |
| Tobacco smoking | D000073869 | — | — | — | — | 1 | — | 19 | 20 |
| Cigarette smoking | D000073865 | — | — | — | — | 1 | — | 13 | 14 |
| Nervous system diseases | D009422 | — | G00-G99 | — | 6 | 7 | — | 1 | 13 |
| Acute pain | D059787 | — | R52 | 2 | 3 | 2 | — | 6 | 11 |
| Herpes zoster | D006562 | EFO_0006510 | B02 | — | 5 | 4 | — | — | 8 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 4 | 3 | — | — | 7 |
Show 29 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Deglutition disorders | D003680 | HP_0002015 | R13.1 | — | 3 | — | — | 8 | 11 |
| Pruritus | D011537 | HP_0000989 | L29 | 1 | 1 | — | — | 8 | 9 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 4 | — | — | 4 | 9 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 2 | 1 | — | — | 4 | 7 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | 3 | — | — | 2 | 5 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | 1 | 1 | — | — | 3 | 5 |
| Chronic pain | D059350 | HP_0012532 | — | — | 1 | — | — | 4 | 5 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | 1 | — | — | 3 | 4 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 1 | — | — | 3 | 4 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | 2 | — | — | 2 | 4 |
Show 42 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic cough | D000096822 | — | — | 1 | — | — | — | 9 | 10 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 2 | — | — | — | 3 | 5 |
| Headache | D006261 | HP_0002315 | R51 | 2 | — | — | — | 3 | 5 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | 2 | — | — | — | 1 | 3 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | 2 | — | — | — | 1 | 3 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | — | — | — | 2 | 3 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 2 | 3 |
| Sclerosis | D012598 | — | — | 2 | — | — | — | — | 2 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | — | — | — | 1 | 2 |
| Rhinorrhea | D000086722 | — | — | 1 | — | — | — | 1 | 2 |
Show 22 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Smoking | D012907 | EFO_0004318 | — | — | — | — | — | 29 | 29 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | — | 6 | 6 |
| Thirst | D013894 | — | — | — | — | — | — | 5 | 5 |
| Hypotrichosis | D007039 | HP_0008070 | — | — | — | — | — | 4 | 4 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 3 | 3 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | — | — | — | 2 | 2 |
| Radiculopathy | D011843 | — | M54.1 | — | — | — | — | 2 | 2 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | — | — | 2 | 2 |
| Metabolism | D008660 | GO_0008152 | — | — | — | — | — | 2 | 2 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | — | — | 2 | 2 |
Show 110 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Menthol |
| INN | racementhol |
| Description | (-)-menthol is a p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. It has a role as an antipruritic drug, an antitussive and an antispasmodic drug. It is an enantiomer of a (+)-menthol. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1CCC(C(C)C)C(O)C1 |
Identifiers
| PDB | — |
| CAS-ID | 114376-98-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL256087 |
| ChEBI ID | 25187 |
| PubChem CID | 16666 |
| DrugBank | DB00825 |
| UNII ID | YS08XHA860 (ChemIDplus, GSRS) |
Target
Agency Approved
ADRA1A
ADRA1A
ADRA2A
ADRA2A
TRPM8
TRPM8
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Alternate
ADRA2B
ADRA2B
HTR1B
HTR1B
HTR1D
HTR1D
TRPA1
TRPA1
ADRA1B
ADRA1B
HTR2C
HTR2C
TRPV3
TRPV3
ADRA2C
ADRA2C
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA2B
Gene synonyms
ADRA2L1, ADRA2RL1
NCBI Gene ID
Protein name
alpha-2B adrenergic receptor
Protein synonyms
ADRA2B adrenergic, alpha-2B-, receptor, Alpha-2 adrenergic receptor subtype C2, alpha-2-adrenergic receptor-like 1, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor, Alpha-2BAR, G-protein coupled receptor
Uniprot ID
Mouse ortholog
Adra2b (11552)
alpha-2B adrenergic receptor (P30545)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Menthol
+
Benzocaine
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Menthol
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Menthol
+
Methyl salicylate
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 59,049 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
4,176 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use