Menthol
Salonpas (menthol) is a small molecule pharmaceutical. Menthol was first approved as Salonpas on 2008-02-20. It is used to treat pain and skin diseases in the USA. The pharmaceutical is active against alpha-1A adrenergic receptor, alpha-2A adrenergic receptor, and transient receptor potential cation channel subfamily M member 8. In addition, it is known to target alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1D, transient receptor potential cation channel subfamily A member 1, alpha-1B adrenergic receptor, 5-hydroxytryptamine receptor 2C, transient receptor potential cation channel subfamily V member 3, alpha-2C adrenergic receptor, and alpha-1D adrenergic receptor.
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Commercial
Trade Name
FDA
EMA
Combinations
Salonpas
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Menthol
+
Methyl salicylate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SALONPAS | Hisamitsu Pharmaceutical | N-022029 OTC | 2008-02-20 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| air sinsinpas-ex | C200263 | 2024-01-05 |
| antiphlamine | unapproved drug other | 2017-05-11 |
| cool pap cataplasma | OTC monograph not final | 2022-01-17 |
| essentials | OTC monograph not final | 2018-12-21 |
| family care pain relief | OTC monograph not final | 2013-11-26 |
| halls | C200263 | 2025-06-16 |
| halls naturals | OTC monograph final | 2013-08-07 |
| hallsmelon splash | OTC monograph final | 2014-02-04 |
| hallssugar free extra | OTC monograph not final | 2014-02-07 |
| mentholatum | unapproved drug other | 2023-07-06 |
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Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
279 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharyngitis | D010612 | — | R07.0 | 2 | — | 3 | 1 | 1 | 7 |
| Gingivitis | D005891 | — | K05.10 | — | — | — | 3 | 2 | 5 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | 3 | 2 | 5 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | 2 | 3 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | — | — | 1 | 1 | 2 |
| Back pain | D001416 | — | M54 | — | — | — | 1 | 1 | 2 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | 1 | 1 | — | 2 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 1 | 1 | 1 | — | 2 |
| Biofilms | D018441 | — | — | — | — | — | 2 | — | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | 1 | 1 | 2 |
Show 19 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tobacco use disorder | D014029 | — | F17 | 11 | 1 | 1 | — | 17 | 29 |
| Tobacco smoking | D000073869 | — | — | — | — | 1 | — | 19 | 20 |
| Pain | D010146 | EFO_0003843 | R52 | 6 | 1 | 2 | — | 2 | 10 |
| Acute pain | D059787 | — | R52 | 1 | 3 | 1 | — | 2 | 5 |
| Smoking cessation | D016540 | EFO_0004319 | — | — | — | 1 | — | 4 | 5 |
| Cough | D003371 | — | R05 | 1 | — | 2 | — | 1 | 4 |
| Harm reduction | D040261 | — | — | — | — | 1 | — | 2 | 3 |
| Colonic neoplasms | D003110 | — | C18 | — | 1 | 1 | — | 1 | 3 |
| Musculoskeletal pain | D059352 | — | — | — | — | 1 | — | 1 | 2 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 2 | — | — | 2 |
Show 11 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Peripheral nervous system diseases | D010523 | — | G64 | 1 | 3 | — | — | 1 | 4 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | 1 | — | — | 2 | 3 |
| Dyspnea | D004417 | — | R06.0 | — | 1 | — | — | 2 | 3 |
| Myalgia | D063806 | — | M79.1 | — | 1 | — | — | 1 | 2 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 1 | — | — | 1 | 2 |
| Abdominal pain | D015746 | EFO_0003766 | R10.9 | 1 | 1 | — | — | — | 2 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | — | — | 1 | 2 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | 1 | — | — | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 1 | 2 |
| Obstructive lung diseases | D008173 | — | — | — | 1 | — | — | 1 | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tobacco use | D064424 | — | Z72.0 | 2 | — | — | — | 30 | 32 |
| Common cold | D003139 | EFO_0007214 | J00 | 2 | — | — | — | 4 | 6 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 4 | 6 |
| Headache | D006261 | — | R51 | 1 | — | — | — | 2 | 3 |
| Hyperalgesia | D006930 | — | — | 1 | — | — | — | 1 | 2 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | 1 | — | — | — | 1 | 2 |
| Pneumonia | D011014 | EFO_0003106 | J18 | 1 | — | — | — | 1 | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 1 | 2 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | 1 | — | — | — | 1 | 2 |
| Covid-19 | D000086382 | — | U07.1 | 1 | — | — | — | 1 | 2 |
Show 8 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Smoking | D012907 | EFO_0004318 | — | — | — | — | — | 30 | 30 |
| Vaping | D000072137 | — | — | — | — | — | — | 22 | 22 |
| Cigarette smoking | D000073865 | — | — | — | — | — | — | 15 | 15 |
| Thirst | D013894 | — | — | — | — | — | — | 6 | 6 |
| Pruritus | D011537 | — | L29 | — | — | — | — | 5 | 5 |
| Syndrome | D013577 | — | — | — | — | — | — | 3 | 3 |
| Tobacco use cessation | D020340 | — | — | — | — | — | — | 3 | 3 |
| Chronic pain | D059350 | — | — | — | — | — | — | 3 | 3 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 3 | 3 |
| Nausea | D009325 | — | R11.0 | — | — | — | — | 3 | 3 |
Show 89 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Menthol |
| INN | racementhol |
| Description | (-)-menthol is a p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. It has a role as an antipruritic drug, an antitussive and an antispasmodic drug. It is an enantiomer of a (+)-menthol. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1CCC(C(C)C)C(O)C1 |
Identifiers
| PDB | — |
| CAS-ID | 114376-98-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL256087 |
| ChEBI ID | 25187 |
| PubChem CID | 16666 |
| DrugBank | DB00825 |
| UNII ID | YS08XHA860 (ChemIDplus, GSRS) |
Target
Agency Approved
ADRA1A
ADRA1A
ADRA2A
ADRA2A
TRPM8
TRPM8
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Alternate
ADRA2B
ADRA2B
HTR1B
HTR1B
HTR1D
HTR1D
TRPA1
TRPA1
ADRA1B
ADRA1B
HTR2C
HTR2C
TRPV3
TRPV3
ADRA2C
ADRA2C
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA2B
Gene synonyms
ADRA2L1, ADRA2RL1
NCBI Gene ID
Protein name
alpha-2B adrenergic receptor
Protein synonyms
ADRA2B adrenergic, alpha-2B-, receptor, Alpha-2 adrenergic receptor subtype C2, alpha-2-adrenergic receptor-like 1, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor, Alpha-2BAR, G-protein coupled receptor
Uniprot ID
Mouse ortholog
Adra2b (11552)
alpha-2B adrenergic receptor (P30545)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Menthol
+
Benzocaine
Total medical expenditures per year (USD, in millions)
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Menthol
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Menthol
+
Methyl salicylate
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4,792 adverse events reported
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