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AboutPricing
Drug ReportsMenthol
Menthol
Salonpas (menthol) is a small molecule pharmaceutical. Menthol was first approved as Salonpas on 2008-02-20. It is used to treat pain and skin diseases in the USA. The pharmaceutical is active against alpha-1A adrenergic receptor, alpha-2A adrenergic receptor, and transient receptor potential cation channel subfamily M member 8. In addition, it is known to target alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1D, transient receptor potential cation channel subfamily A member 1, alpha-1B adrenergic receptor, 5-hydroxytryptamine receptor 2C, transient receptor potential cation channel subfamily V member 3, alpha-2C adrenergic receptor, and alpha-1D adrenergic receptor.
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YTD
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EMA approval date
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Study first post date
Last update post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Combinations
Salonpas
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Menthol
+
Methyl salicylate
Tradename
Company
Number
Date
Products
SALONPASHisamitsu PharmaceuticalN-022029 OTC2008-02-20
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
air sinsinpas-exC2002632024-01-05
antiphlamineunapproved drug other2017-05-11
cool pap cataplasmaOTC monograph not final2022-01-17
essentialsOTC monograph not final2018-12-21
family care pain reliefOTC monograph not final2013-11-26
hallsC2002632025-03-16
halls naturalsOTC monograph final2013-08-07
hallsmelon splashOTC monograph final2014-02-04
hallssugar free extraOTC monograph not final2014-02-07
mentholatumunapproved drug other2023-07-06
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
arthritisEFO_0005856D001168M05-M14
inflammationMP_0001845D007249—
acute pain—D059787R52
sprains and strains—D013180—
skin diseases—D012871L00-L99
contusions—D003288T14.8
back pain—D001416M54
muscle cramp—D009120—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Menthol / Methyl Salicylate, Salonpas, Hisamitsu Pharm Co
88096152030-01-03DP
92331842027-08-01DP
ATC Codes
No data
HCPCS
No data
Clinical
No data
Drug
General
Drug common nameMenthol
INNracementhol
Description
(-)-menthol is a p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. It has a role as an antipruritic drug, an antitussive and an antispasmodic drug. It is an enantiomer of a (+)-menthol.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC1CCC(C(C)C)C(O)C1
Identifiers
PDB—
CAS-ID114376-98-6
RxCUI—
ChEMBL IDCHEMBL256087
ChEBI ID25187
PubChem CID16666
DrugBankDB00825
UNII IDYS08XHA860 (ChemIDplus, GSRS)
Target
Agency Approved
ADRA1A
ADRA1A
ADRA2A
ADRA2A
TRPM8
TRPM8
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
148
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Q9UD67
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Alternate
ADRA2B
ADRA2B
HTR1B
HTR1B
HTR1D
HTR1D
TRPA1
TRPA1
ADRA1B
ADRA1B
HTR2C
HTR2C
TRPV3
TRPV3
ADRA2C
ADRA2C
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA2B
Gene synonyms
ADRA2L1, ADRA2RL1
NCBI Gene ID
151
Protein name
alpha-2B adrenergic receptor
Protein synonyms
ADRA2B adrenergic, alpha-2B-, receptor, Alpha-2 adrenergic receptor subtype C2, alpha-2-adrenergic receptor-like 1, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor, Alpha-2BAR, G-protein coupled receptor
Uniprot ID
Q9BZK0
Mouse ortholog
Adra2b (11552)
alpha-2B adrenergic receptor (P30545)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Menthol
+
Benzocaine
Total medical expenditures per year (USD, in millions)
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Menthol
Total medical expenditures per year (USD, in millions)
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Menthol
+
Methyl salicylate
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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