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Drug ReportsMeloxicam
Mobic, Zynrelef(meloxicam)
Meloxicam, Symbravo, Zynrelef (meloxicam) is a small molecule pharmaceutical. Meloxicam was first approved as Mobic on 2000-04-13. It is used to treat osteoarthritis and rheumatoid arthritis in the USA. It has been approved in Europe to treat postoperative pain. The pharmaceutical is active against prostaglandin G/H synthase 2. In addition, it is known to target prostaglandin G/H synthase 1.
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Drug
Target
Variants
Financial
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Events Timeline
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3M
6M
YTD
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Meloxicam, Qamzova, Xifyrm (discontinued: Anjeso, Meloxicam, Mobic, Qmiiz, Vivlodex)
Combinations
Symbravo, Zynrelef (discontinued: Zynrelef)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Meloxicam
Tradename
Company
Number
Date
Products
MELOXICAMAvondale PharmaceuticalsN-021530 RX2004-06-01
1 products, RLD, RS
XIFYRMAzurityN-218395 RX2025-06-05
1 products, RLD, RS
QAMZOVANanjing Simcere Dongyuan PharmaceuticalN-217593 RX2025-04-22
1 products, RLD, RS
Show 4 discontinued
Bupivacaine
+
Meloxicam
Tradename
Company
Number
Date
Products
ZYNRELEF KITHeron TherapeuticsN-211988 RX2021-05-12
2 products, RLD, RS
Show 1 discontinued
Meloxicam
+
Rizatriptan benzoate
Tradename
Company
Number
Date
Products
SYMBRAVOAxsome TherapeuticsN-215431 RX2025-01-30
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
meloxicamANDA2025-12-19
mobicANDA2021-03-30
qamzovaNew Drug Application2025-04-23
symbravoNew Drug Application2025-11-21
trepoxicamunapproved drug other2010-10-25
trepoxicam-7.5unapproved drug other2011-08-01
vivlodexNew Drug Application2021-04-30
xifyrmNew Drug Application2025-06-18
zynrelefNew Drug Application2025-05-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
rheumatoid arthritisEFO_0000685D001172M06.9
osteoarthritisEFO_0002506D010003M15-M19
postoperative pain—D010149G89.18
migraine disordersEFO_0003821D008881G43
Agency Specific
FDA
EMA
Expiration
Code
BUPIVACAINE / MELOXICAM, ZYNRELEF KIT, HERON THERAPS INC
2024-05-12NP
MELOXICAM, ANJESO, BAUDAX
2023-02-20NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Meloxicam, Anjeso, Baudax
108816632039-03-08U-3038
114581452039-03-08U-3318
99747462030-05-26DP
107097132030-05-26U-2750
112534782030-05-26DPU-3318
104636732024-02-24DPU-2750
104710672024-02-24DPU-2750
Bupivacaine / Meloxicam, Zynrelef Kit, Heron Theraps Inc
96940792035-04-20DPU-3118
98019452035-04-20DPU-3118
100989572035-04-20U-3118
102135102035-04-20DPU-3118
106321992035-04-20DPU-3118
108985752035-04-20DPU-3118
109808862035-04-20DP
110837302035-04-20DPU-3118
110837972035-04-20DPU-3118
114133502035-04-20U-3417
95922272034-03-13DPU-3118
97441632034-03-13DP
99139092034-03-13U-3118
103986862034-03-13DP
112535042034-03-13U-3118
Meloxicam, Vivlodex, Iceutica Operations
96493182035-03-31DP
98084682035-03-31U-2160, U-2165
95267342033-03-31DP
Meloxicam, Qmiiz Odt, Tersera
85458792030-08-31DP
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AC: Oxicams, antiinflammatory and antirheumatic drugs
— M01AC06: Meloxicam
— M01AC56: Meloxicam, combinations
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BB: Amide local anesthetics
— N01BB59: Bupivacaine and meloxicam
HCPCS
Code
Description
C9088
Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg
J1738
Injection, meloxicam, 1 mg
Clinical
Clinical Trials
152 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InflammationD007249MP_0001845—————22
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMeloxicam
INNmeloxicam
Description
Meloxicam is a benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis. It has a role as a non-steroidal anti-inflammatory drug, an antirheumatic drug, a cyclooxygenase 2 inhibitor and an analgesic. It is a benzothiazine, a monocarboxylic acid amide and a member of 1,3-thiazoles.
Classification
Small molecule
Drug classanti-inflammatory agents (isoxicam type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1
Identifiers
PDB—
CAS-ID71125-38-7
RxCUI—
ChEMBL IDCHEMBL599
ChEBI ID6741
PubChem CID54677470
DrugBankDB00814
UNII IDVG2QF83CGL (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Zynrelef – Heron Therapeutics /de/
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Estimated US medical usage
Meloxicam
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 18,452 documents
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Safety
Black-box Warning
Black-box warning for: Meloxicam, Qamzova, Symbravo, Trepoxicam, Trepoxicam-7.5, Vivlodex, Xifyrm, Zynrelef
Adverse Events
Top Adverse Reactions
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13,302 adverse events reported
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