Mobic, Zynrelef(meloxicam)
Meloxicam, Zynrelef (meloxicam) is a small molecule pharmaceutical. Meloxicam was first approved as Mobic on 2000-04-13. It is used to treat osteoarthritis and rheumatoid arthritis in the USA. It has been approved in Europe to treat postoperative pain. The pharmaceutical is active against prostaglandin G/H synthase 2. In addition, it is known to target prostaglandin G/H synthase 1.
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Commercial
Trade Name
FDA
EMA
Meloxicam (discontinued: Anjeso, Meloxicam, Mobic, Qmiiz, Vivlodex)
CombinationsZynrelef (discontinued: Zynrelef)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Meloxicam
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MELOXICAM | Avondale Pharmaceuticals | N-021530 RX | 2004-06-01 | 1 products, RLD, RS |
Show 4 discontinued
Bupivacaine
+
Meloxicam
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZYNRELEF KIT | Heron Therapeutics | N-211988 RX | 2021-05-12 | 2 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| meloxicam | ANDA | 2024-10-30 |
| mobic | ANDA | 2021-03-30 |
| trepoxicam | unapproved drug other | 2010-10-25 |
| trepoxicam-7.5 | unapproved drug other | 2011-08-01 |
| vivlodex | New Drug Application | 2021-04-30 |
| zynrelef | New Drug Application | 2024-09-10 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| rheumatoid arthritis | EFO_0000685 | D001172 | M06.9 |
| osteoarthritis | EFO_0002506 | D010003 | M15-M19 |
| postoperative pain | — | D010149 | G89.18 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
BUPIVACAINE / MELOXICAM, ZYNRELEF KIT, HERON THERAPS INC | |||
| 2024-05-12 | NP | ||
MELOXICAM, ANJESO, BAUDAX | |||
| 2023-02-20 | NP | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Meloxicam, Anjeso, Baudax | |||
| 10881663 | 2039-03-08 | U-3038 | |
| 11458145 | 2039-03-08 | U-3318 | |
| 9974746 | 2030-05-26 | DP | |
| 10709713 | 2030-05-26 | U-2750 | |
| 11253478 | 2030-05-26 | DP | U-3318 |
| 10463673 | 2024-02-24 | DP | U-2750 |
| 10471067 | 2024-02-24 | DP | U-2750 |
| Bupivacaine / Meloxicam, Zynrelef Kit, Heron Theraps Inc | |||
| 9694079 | 2035-04-20 | DP | U-3118 |
| 9801945 | 2035-04-20 | DP | U-3118 |
| 10098957 | 2035-04-20 | U-3118 | |
| 10213510 | 2035-04-20 | DP | U-3118 |
| 10632199 | 2035-04-20 | DP | U-3118 |
| 10898575 | 2035-04-20 | DP | U-3118 |
| 10980886 | 2035-04-20 | DP | |
| 11083730 | 2035-04-20 | DP | U-3118 |
| 11083797 | 2035-04-20 | DP | U-3118 |
| 11413350 | 2035-04-20 | U-3417 | |
| 9592227 | 2034-03-13 | DP | U-3118 |
| 9744163 | 2034-03-13 | DP | |
| 9913909 | 2034-03-13 | U-3118 | |
| 10398686 | 2034-03-13 | DP | |
| 11253504 | 2034-03-13 | U-3118 | |
| Meloxicam, Vivlodex, Iceutica Operations | |||
| 9649318 | 2035-03-31 | DP | |
| 9808468 | 2035-03-31 | U-2160, U-2165 | |
| 9526734 | 2033-03-31 | DP | |
| Meloxicam, Qmiiz Odt, Tersera | |||
| 8545879 | 2030-08-31 | DP | |
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AC: Oxicams, antiinflammatory and antirheumatic drugs
— M01AC06: Meloxicam
— M01AC56: Meloxicam, combinations
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BB: Amide local anesthetics
— N01BB59: Bupivacaine and meloxicam
Clinical
Clinical Trials
155 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 1 | 10 | 8 | 6 | 4 | 29 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 3 | 8 | 5 | 8 | 23 |
| Healthy volunteers/patients | — | — | — | 19 | — | — | 1 | — | 20 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 2 | 4 | 5 | 3 | 13 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | — | 4 | 2 | 5 | 11 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 2 | 1 | 7 | 10 |
| Spondylarthritis | D025241 | — | — | — | 3 | 2 | 1 | — | 5 |
| Spondylitis | D013166 | — | M46.9 | — | 3 | 2 | 1 | — | 5 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | 2 | 2 | 1 | — | 4 |
| Radiculopathy | D011843 | — | M54.1 | — | — | — | 1 | 2 | 3 |
Show 17 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | 4 | — | 1 | 5 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | 3 | — | 1 | 4 |
| Back pain | D001416 | HP_0003418 | M54 | — | — | 2 | — | 2 | 4 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 1 | — | 2 | 4 |
| Shoulder pain | D020069 | HP_0030834 | M25.51 | — | — | 2 | — | — | 2 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | — | — | 2 | — | — | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | 2 | 2 | — | — | 2 |
| Second primary neoplasms | D016609 | — | — | — | 2 | 2 | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 2 | 2 | — | — | 2 |
| Dysmenorrhea | D004412 | HP_0100607 | N94.6 | — | 2 | 1 | — | — | 2 |
Show 13 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bunion | D000071378 | — | M21.61 | — | 1 | — | — | 1 | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 2 | — | — | — | 2 |
| Multiple myeloma | D009101 | — | C90.0 | — | 2 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | — | 2 | — | — | — | 2 |
| Rupture | D012421 | — | — | — | 1 | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | — | 1 | — | — | — | 1 |
| Hodgkin disease | D006689 | — | C81 | — | 1 | — | — | — | 1 |
| Hematopoiesis | D006410 | — | — | — | 1 | — | — | — | 1 |
| Tonsillitis | D014069 | HP_0011110 | J03 | — | 1 | — | — | — | 1 |
| Impacted tooth | D014095 | HP_0011079 | K01.1 | — | 1 | — | — | — | 1 |
Show 4 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Contraception | D003267 | — | — | 2 | — | — | — | — | 2 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | 1 | — | — | — | — | 1 |
| Feeding behavior | D005247 | — | — | 1 | — | — | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intervertebral disc degeneration | D055959 | HP_0008419 | — | — | — | — | — | 7 | 7 |
| Spinal diseases | D013122 | — | M45-M49 | — | — | — | — | 5 | 5 |
| Intervertebral disc displacement | D007405 | EFO_1001800 | — | — | — | — | — | 5 | 5 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 2 | 2 |
| Rheumatic diseases | D012216 | — | M79.0 | — | — | — | — | 2 | 2 |
| Collagen diseases | D003095 | — | — | — | — | — | — | 2 | 2 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | — | — | 1 | 1 |
| Pain management | D059408 | — | — | — | — | — | — | 1 | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
Show 21 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Meloxicam |
| INN | meloxicam |
| Description | Meloxicam is a benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis. It has a role as a non-steroidal anti-inflammatory drug, an antirheumatic drug, a cyclooxygenase 2 inhibitor and an analgesic. It is a benzothiazine, a monocarboxylic acid amide and a member of 1,3-thiazoles. |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (isoxicam type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 |
Identifiers
| PDB | — |
| CAS-ID | 71125-38-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL599 |
| ChEBI ID | 6741 |
| PubChem CID | 54677470 |
| DrugBank | DB00814 |
| UNII ID | VG2QF83CGL (ChemIDplus, GSRS) |
Target
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Variants
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Zynrelef – Heron Therapeutics /de/
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Estimated US medical usage
Meloxicam
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Meloxicam, Trepoxicam, Trepoxicam-7.5, Vivlodex, Zynrelef
Adverse Events
Top Adverse Reactions
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12,333 adverse events reported
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