Mavorixafor
Xolremdi (mavorixafor) is a small molecule pharmaceutical. Mavorixafor was first approved as Xolremdi on 2024-04-26. It is used to treat infections and warts in the USA. The pharmaceutical is active against C-X-C chemokine receptor type 4.
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FDA approval date
EMA approval date
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Study first post date
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Xolremdi
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mavorixafor
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| XOLREMDI | X4 Pharmaceuticals | N-218709 RX | 2024-04-26 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| xolremdi | New Drug Application | 2024-11-12 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| infections | EFO_0000544 | D007239 | — |
| warts | — | D014860 | B07 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | 1 | 1 | — | — | 2 |
| Neutropenia | D009503 | — | D70 | 1 | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 2 | 2 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Waldenstrom macroglobulinemia | D008258 | — | C88.0 | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
| Liver failure | D017093 | — | K72.9 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mavorixafor |
| INN | mavorixafor |
| Description | AMD 070 is an aminoquinoline. |
| Classification | Small molecule |
| Drug class | CXCR receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCCCN(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc21 |
Identifiers
| PDB | — |
| CAS-ID | 558441-90-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL518924 |
| ChEBI ID | — |
| PubChem CID | 11256587 |
| DrugBank | DB05501 |
| UNII ID | 0G9LGB5O2W (ChemIDplus, GSRS) |
Target
Agency Approved
CXCR4
CXCR4
Organism
Homo sapiens
Gene name
CXCR4
Gene synonyms
NCBI Gene ID
Protein name
C-X-C chemokine receptor type 4
Protein synonyms
CD184, CD184 antigen, chemokine (C-X-C motif) receptor 4, FB22, Fusin, HM89, LAP-3, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, Lipopolysaccharide-associated protein 3, LPS-associated protein 3, neuropeptide Y receptor Y3, neuropeptide Y3 receptor, NPYRL, SDF-1 receptor, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor
Uniprot ID
Mouse ortholog
Cxcr4 (12767)
C-X-C chemokine receptor type 4 (Q4KMW1)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 313 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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11 adverse events reported
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