Lumefantrine
Coartem (lumefantrine) is a small molecule pharmaceutical. Lumefantrine was first approved as Coartem on 2009-04-07. It is used to treat falciparum malaria and malaria in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
Combinations
Coartem
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| coartem | New Drug Application | 2026-03-26 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| malaria | EFO_0001068 | D008288 | B54 |
| falciparum malaria | EFO_0007444 | D016778 | B50 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
No data
Clinical
Clinical Trials
250 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | 21 | 20 | 47 | 73 | 47 | 199 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | 8 | 19 | 26 | 35 | 23 | 102 |
| Vivax malaria | D016780 | EFO_0007445 | B51 | 1 | 1 | 2 | 7 | 6 | 17 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | — | 1 | 6 | — | 9 |
| Recurrence | D012008 | — | — | 1 | — | — | 1 | 4 | 6 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | 3 | 2 | 5 |
| Hiv | D006678 | — | O98.7 | 2 | — | — | 2 | — | 4 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | 1 | 3 | 4 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | — | 3 | — | 4 |
| Schistosomiasis | D012552 | EFO_1001475 | B65 | — | 1 | — | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | — | 1 | — | 1 | 4 |
| Protozoan infections | D011528 | — | B50-B64 | 3 | — | 1 | — | — | 4 |
| Fever | D005334 | — | R50.9 | — | — | 1 | — | 2 | 3 |
| Glucosephosphate dehydrogenase deficiency | D005955 | EFO_0007287 | — | — | 1 | 2 | — | — | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | — | 1 | — | — | 1 |
| Disease susceptibility | D004198 | — | — | — | — | 1 | — | — | 1 |
| Cardiotoxicity | D066126 | EFO_1001482 | — | — | — | 1 | — | — | 1 |
| Asymptomatic diseases | D058070 | — | — | — | 1 | 1 | — | — | 1 |
| Hemolytic anemia | D000743 | — | D55-D59 | — | — | 1 | — | — | 1 |
| Patient compliance | D010349 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | 2 | — | — | — | 4 |
| Combination drug therapy | D004359 | — | — | 2 | 1 | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 2 | 1 | — | — | — | 2 |
| Schistosomiasis haematobia | D012553 | EFO_0007530 | B65.0 | — | 1 | — | — | — | 1 |
| Coinfection | D060085 | — | — | — | 1 | — | — | — | 1 |
| Ebola hemorrhagic fever | D019142 | EFO_0007243 | A98.4 | — | 1 | — | — | — | 1 |
| Virus diseases | D014777 | — | B34 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parasitic diseases | D010272 | EFO_0001067 | B88 | 3 | — | — | — | — | 3 |
| Parasitemia | D018512 | — | — | 3 | — | — | — | — | 3 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | — | 1 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | 1 | — | — | — | — | 1 |
| Vector borne diseases | D000079426 | — | — | 1 | — | — | — | — | 1 |
| Pathologic processes | D010335 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 1 | 1 |
| Severe acute malnutrition | D000067011 | — | — | — | — | — | — | 1 | 1 |
| Diarrhea | D003967 | — | R19.7 | — | — | — | — | 1 | 1 |
| Chemoprevention | D018890 | — | — | — | — | — | — | 1 | 1 |
| Asymptomatic infections | D058345 | — | — | — | — | — | — | 1 | 1 |
| Persistent infection | D000088562 | — | — | — | — | — | — | 1 | 1 |
| Impacted tooth | D014095 | — | K01.1 | — | — | — | — | 1 | 1 |
| Drug resistance | D004351 | — | Z16.30 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lumefantrine |
| INN | lumefantrine |
| Description | Lumefantrine is a member of the class of fluorenes that is 9-(p-chlorobenzylidene)-9H-fluorene which is substitutec by chlorine at positions 2 and 7, and by a 2-(dibutylamino)-1-hydroxyethyl group at position 4. An antimalarial drug used in combination with artemether for the treatment of multi-drug resistant strains of falciparum malaria. It has a role as an antimalarial. It is a tertiary amine, a member of monochlorobenzenes, a secondary alcohol and a member of fluorenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 82186-77-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL38827 |
| ChEBI ID | 156095 |
| PubChem CID | 6437380 |
| DrugBank | DB06708 |
| UNII ID | F38R0JR742 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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357 adverse events reported
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