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AboutPricing
Drug ReportsLumefantrine
Lumefantrine
Coartem (lumefantrine) is a small molecule pharmaceutical. Lumefantrine was first approved as Coartem on 2009-04-07. It is used to treat falciparum malaria and malaria in the USA.
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YTD
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2Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
Trade Name
FDA
EMA
Combinations
Coartem
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Artemether
+
Lumefantrine
Tradename
Company
Number
Date
Products
COARTEMNovartisN-022268 RX2009-04-07
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
coartemNew Drug Application2025-06-17
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
malariaEFO_0001068D008288B54
falciparum malariaEFO_0007444D016778B50
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P01: Antiprotozoals
— P01B: Antimalarials
— P01BF: Artemisinin and derivatives, combinations
— P01BF01: Artemether and lumefantrine
HCPCS
No data
Clinical
Clinical Trials
238 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalariaD008288EFO_0001068B543554116
Falciparum malariaD016778EFO_0007444B50—553—11
Trigeminal neuralgiaD014277EFO_1001219G50.0———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Body weightD001835EFO_0004338——11——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLumefantrine
INNlumefantrine
Description
Lumefantrine is a member of the class of fluorenes that is 9-(p-chlorobenzylidene)-9H-fluorene which is substitutec by chlorine at positions 2 and 7, and by a 2-(dibutylamino)-1-hydroxyethyl group at position 4. An antimalarial drug used in combination with artemether for the treatment of multi-drug resistant strains of falciparum malaria. It has a role as an antimalarial. It is a tertiary amine, a member of monochlorobenzenes, a secondary alcohol and a member of fluorenes.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc1
Identifiers
PDB—
CAS-ID82186-77-4
RxCUI—
ChEMBL IDCHEMBL38827
ChEBI ID156095
PubChem CID6437380
DrugBankDB06708
UNII IDF38R0JR742 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,308 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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339 adverse events reported
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