Lumefantrine
Coartem (lumefantrine) is a small molecule pharmaceutical. Lumefantrine was first approved as Coartem on 2009-04-07. It is used to treat falciparum malaria and malaria in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
Combinations
Coartem
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| coartem | New Drug Application | 2025-06-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| malaria | EFO_0001068 | D008288 | B54 |
| falciparum malaria | EFO_0007444 | D016778 | B50 |
Agency Specific
FDA
EMA
No data
Patent Expiration
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HCPCS
No data
Clinical
Clinical Trials
239 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | 3 | 7 | 5 | 4 | 1 | 18 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | — | 7 | 5 | 3 | — | 13 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Body weight | D001835 | EFO_0004338 | — | — | 1 | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | 2 | — | — | — | 4 |
| Combination drug therapy | D004359 | — | — | 2 | 1 | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 2 | 1 | — | — | — | 2 |
| Schistosomiasis haematobia | D012553 | EFO_0007530 | B65.0 | — | 1 | — | — | — | 1 |
| Ebola hemorrhagic fever | D019142 | EFO_0007243 | A98.4 | — | 1 | — | — | — | 1 |
| Virus diseases | D014777 | — | B34 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 1 | — | — | — | 4 | 5 |
| Parasitic diseases | D010272 | EFO_0001067 | B88 | 2 | — | — | — | — | 2 |
| Parasitemia | D018512 | — | — | 2 | — | — | — | — | 2 |
| Protozoan infections | D011528 | — | B50-B64 | 2 | — | — | — | — | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 2 | 2 |
| Severe acute malnutrition | D000067011 | — | — | — | — | — | — | 2 | 2 |
| Hyperthermia | D000084462 | — | — | — | — | — | — | 1 | 1 |
| Diarrhea | D003967 | — | R19.7 | — | — | — | — | 1 | 1 |
| Chemoprevention | D018890 | — | — | — | — | — | — | 1 | 1 |
| Wasting syndrome | D019282 | — | — | — | — | — | — | 1 | 1 |
| Cachexia | D002100 | — | R64 | — | — | — | — | 1 | 1 |
| Kwashiorkor | D007732 | EFO_1001009 | E40 | — | — | — | — | 1 | 1 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lumefantrine |
| INN | lumefantrine |
| Description | Lumefantrine is a member of the class of fluorenes that is 9-(p-chlorobenzylidene)-9H-fluorene which is substitutec by chlorine at positions 2 and 7, and by a 2-(dibutylamino)-1-hydroxyethyl group at position 4. An antimalarial drug used in combination with artemether for the treatment of multi-drug resistant strains of falciparum malaria. It has a role as an antimalarial. It is a tertiary amine, a member of monochlorobenzenes, a secondary alcohol and a member of fluorenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 82186-77-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL38827 |
| ChEBI ID | 156095 |
| PubChem CID | 6437380 |
| DrugBank | DB06708 |
| UNII ID | F38R0JR742 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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335 adverse events reported
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