Lotamilast
Lotamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Labels
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| 10% methyl salicylate pain relief patch | C200263 | 2024-06-27 |
| 1st medxpatch | C200263 | 2024-10-31 |
| 365 whole foods market anticavity/antigingivitis mouthwash | OTC monograph not final | 2022-05-12 |
| 701 dieda zhengtong yaogao medicated | OTC monograph not final | 2019-11-13 |
| 701 dieda zhengtong yaogao medicated plaster | OTC monograph not final | 2014-06-26 |
| absolut skin spf 50 moisturizing sunscreen | C200263 | 2025-04-09 |
| advanced antiseptic citrus | C200263 | 2025-02-20 |
| advanced citrus antiseptic | C200263 | 2025-01-10 |
| advil targeted relief | C200263 | 2024-02-08 |
| ageless pain relief | C200263 | 2023-12-12 |
Show 692 more
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Clinical
Clinical Trials
676 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | — | — | 1 | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 21 | 3 | — | — | 9 | 33 |
| Neoplasms | D009369 | — | C80 | 17 | 14 | — | — | 2 | 29 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 14 | 11 | — | — | 2 | 18 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 7 | 8 | — | — | 1 | 12 |
| Squamous cell carcinoma | D002294 | — | — | 5 | 6 | — | — | 1 | 9 |
| Lung neoplasms | D008175 | — | C34.90 | 6 | 4 | — | — | 1 | 9 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 4 | 4 | — | — | 1 | 8 |
| Fibrosis | D005355 | — | — | — | 2 | — | — | 6 | 8 |
| Myelodysplastic syndromes | D009190 | — | D46 | 4 | 5 | — | — | — | 7 |
| Multiple myeloma | D009101 | — | C90.0 | 5 | 2 | — | — | — | 7 |
Show 214 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Shoulder pain | D020069 | — | M25.51 | 2 | — | — | — | 2 | 4 |
| Bursitis | D002062 | EFO_1000941 | M71.9 | 1 | — | — | — | 2 | 3 |
| Heart disease risk factors | D000082742 | — | — | 3 | — | — | — | — | 3 |
| Vasoconstriction | D014661 | — | — | 3 | — | — | — | — | 3 |
| Disease | D004194 | EFO_0000408 | R69 | 3 | — | — | — | — | 3 |
| Contraception | D003267 | — | — | 2 | — | — | — | — | 2 |
| Serous cystadenocarcinoma | D018284 | — | — | 2 | — | — | — | — | 2 |
| Hepatic insufficiency | D048550 | — | — | 2 | — | — | — | — | 2 |
| Abdominal pain | D015746 | EFO_0003766 | R10.9 | 1 | — | — | — | 1 | 2 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | — | — | — | 1 | 2 |
Show 55 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | — | — | 4 | 4 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | — | — | — | 4 | 4 |
| Trigger finger disorder | D052582 | — | M65.3 | — | — | — | — | 3 | 3 |
| Overweight | D050177 | — | E66.3 | — | — | — | — | 3 | 3 |
| Dystocia | D004420 | EFO_1000911 | O66.9 | — | — | — | — | 2 | 2 |
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | — | — | — | — | 2 | 2 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | — | — | — | 2 | 2 |
| Minimally invasive surgical procedures | D019060 | — | — | — | — | — | — | 2 | 2 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 2 | 2 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | — | — | — | 2 | 2 |
Show 121 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lotamilast |
| INN | lotamilast |
| Description | Lotamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Small molecule |
| Drug class | antiasthmatics/antiallergics (not acting primarily as antihistamines): type IV phosphodiesterase |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNc1nc(-c2cccc(NC(=O)c3ccc(C(=O)OC)cc3)c2)c2cc(OC)c(OC)cc2n1 |
Identifiers
| PDB | — |
| CAS-ID | 947620-48-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989967 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | TO043KKB9C (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Aptensio xr, Concerta, Cotempla xr-odt, Covaryx, Covaryx covaryx, Daytrana, Diclovix m, Dyural 40 kit, Dyural 80 kit, Dyural 80-lm, Dyural lm kit, Eemt, Eemt eemt, Esterified estrogens and methyltestosterone, Esterified estrogens and methyltestosterone full strength esterified estrogens and methyltestosterone half strength, Estratest f.s., Estratest f.s. estratest h.s., Estratest fs estratest hs, Fenovar, Healthy mamabe well rounded, Hycodan, Hydrocodone bitartrate and homatropine methylbromide, Hydromet, Jornay pm, Metadate cd, Metadate er, Methylene blue, Methylin, Methylphenidate, Methylphenidate hydrochloride, Methylphenidate hydrochloride (la), Methylphenidate hydrochloride extended release, Methylphenidate transdermal system, Perseris, Physicians ez use m-pred, Prenate elite, Prenate essential, Provayblue, Quillichew er, Quillivant, Relexxii, Ritalin, Varophen
Adverse Events
0 adverse events reported
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