Lipegfilgrastim
Lonquex (lipegfilgrastim) is a protein pharmaceutical. Lipegfilgrastim was first approved as Lonquex on 2013-07-25. It has been approved in Europe to treat neutropenia.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| hemic and lymphatic diseases | D006425 |
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Clinical
Clinical Trials
400 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 11 | 50 | 24 | 9 | 11 | 98 |
| Lymphoma | D008223 | — | C85.9 | 23 | 61 | 14 | 3 | 3 | 89 |
| Neutropenia | D009503 | — | D70 | 6 | 16 | 19 | 5 | 8 | 51 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 12 | 22 | 1 | 2 | 4 | 34 |
| B-cell lymphoma | D016393 | — | — | 8 | 17 | 7 | 1 | 1 | 30 |
| Neoplasms | D009369 | — | C80 | 10 | 12 | 2 | 1 | 2 | 26 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 9 | 15 | 4 | 1 | 1 | 24 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 9 | 2 | 2 | 3 | 18 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 10 | 2 | 1 | 1 | 16 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 4 | 10 | 1 | 1 | 1 | 14 |
Show 4 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 5 | 23 | 4 | — | — | 25 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | 13 | 3 | — | 1 | 18 |
| Plasma cell neoplasms | D054219 | — | — | 3 | 12 | 3 | — | 1 | 17 |
| Sarcoma | D012509 | — | — | 4 | 10 | 2 | — | 2 | 16 |
| Carcinoma | D002277 | — | C80.0 | 3 | 9 | 2 | — | 1 | 15 |
| Recurrence | D012008 | — | — | 5 | 9 | 2 | — | — | 14 |
| Chemotherapy-induced febrile neutropenia | D064146 | — | — | — | 4 | 7 | — | 4 | 14 |
| Hodgkin disease | D006689 | — | C81 | 4 | 7 | 5 | — | — | 13 |
| Febrile neutropenia | D064147 | — | — | — | 2 | 3 | — | 6 | 11 |
| Adenocarcinoma | D000230 | — | — | 3 | 5 | 1 | — | 1 | 10 |
Show 31 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoid leukemia | D007945 | — | C91 | 3 | 14 | — | — | — | 14 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 2 | 9 | — | — | — | 9 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | 8 | — | — | — | 8 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 5 | 2 | — | — | 1 | 8 |
| Prostatic neoplasms | D011471 | — | C61 | 4 | 5 | — | — | — | 7 |
| Transitional cell carcinoma | D002295 | — | — | — | 6 | — | — | 1 | 7 |
| Mantle-cell lymphoma | D020522 | — | — | 4 | 4 | — | — | — | 6 |
| Central nervous system neoplasms | D016543 | — | — | 2 | 5 | — | — | — | 6 |
| Head and neck neoplasms | D006258 | — | — | 3 | 3 | — | — | — | 5 |
| Ewing sarcoma | D012512 | EFO_0000173 | — | 2 | 3 | — | — | — | 5 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 16 | — | — | — | 1 | 17 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 2 | — | — | — | 2 | 4 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | — | — | 1 | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | — | — | — | 1 | 2 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | — | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| T-cell lymphoma cutaneous | D016410 | — | — | 1 | — | — | — | — | 1 |
| Vaccine immunogenicity | D000071497 | — | — | 1 | — | — | — | — | 1 |
Show 14 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pheochromocytoma | D010673 | — | — | — | — | — | — | 2 | 2 |
| Coronary disease | D003327 | — | — | — | — | — | — | 1 | 1 |
| Bone nails | D001858 | — | — | — | — | — | — | 1 | 1 |
| Patient reported outcome measures | D000071066 | — | — | — | — | — | — | 1 | 1 |
| Patient satisfaction | D017060 | — | — | — | — | — | — | 1 | 1 |
| Patient preference | D057240 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lipegfilgrastim |
| INN | lipegfilgrastim |
| Description | Lipegfilgrastim, sold under the brand name Lonquex, is a medication used to reduce the duration of neutropenia and the incidence of febrile neutropenia in adults. It is given by injection under the skin in the abdomen, upper arm or thigh.
|
| Classification | Protein |
| Drug class | colony-stimulating factors: granulocyte colony-stimulating factors (G-CSF); PEGylated compounds, covalent attachment of macrogol (polyethylene glycol) polymer |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1117844-87-7 |
| RxCUI | 1440046 |
| ChEMBL ID | CHEMBL4594230 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB13200 |
| UNII ID | 4AWF0N6QV3 (ChemIDplus, GSRS) |
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Safety
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447 adverse events reported
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