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Drug ReportsLidocaine
Xylocaine, Fortacin(lidocaine)
/ Lidocaine, Akten, Duocaine, Embolex, Fortacin, Glydo, Lanabiotic, Laryng-o-jet, Lidocaine, Lidocaine /, Lidoderm, Lignospan, Oraqix, Pliaglis, Rocephin, Synera, Terramycin, Xylocaine, Zingo, Ztlido (lidocaine) is a small molecule pharmaceutical. Lidocaine was first approved as Decadron w/ xylocaine on 1982-01-01. It is used to treat burns, cardiac arrhythmias, esophageal diseases, mouth diseases, and pain amongst others in the USA. It has been approved in Europe to treat physiological sexual dysfunction and premature ejaculation. The pharmaceutical is active against sodium channel protein type 5 subunit alpha. In addition, it is known to target sodium channel protein type 2 subunit alpha, sodium channel protein type 4 subunit alpha, sodium channel protein type 9 subunit alpha, and sodium channel protein type 10 subunit alpha.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
stomatognathic diseasesD009057
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
psychological phenomenaD011579
mental disordersD001523
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Akten, Glydo, Laryng-o-jet, Lidocaine, Lidocaine viscous, Lidoderm, Zingo, Ztlido (discontinued: Anestacon, Dentipatch, Laryngotracheal anesthesia, Lidocaine, Lidocaine viscous, Lidopen, Lta, Xylocaine, Xylocaine viscous, Xylocaine w/ glucose)
Combinations
Lidocaine epinephrine, Lidocaine prilocaine, Lignospan, Lignospan standard, Oraqix, Xylocaine w/ epinephrine (discontinued: Decadron w/ xylocaine, Duocaine, Embolex, Emla, Iontocaine, Lanabiotic, Lidocaine epinephrine, Lidocaine prilocaine, Lidocaine w/ epinephrine, Lidosite topical system, Octocaine, Pliaglis, Rocephin, Synera, Terramycin, Xylocaine w/ epinephrine, Xylocaine with epinephrine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lidocaine
+
Prilocaine
Tradename
Company
Number
Date
Products
ORAQIXDentsply PharmaceuticalN-021451 RX2003-12-19
1 products, RLD, RS
Show 2 discontinued
Lidocaine
+
Tetracaine
Tradename
Company
Number
Date
Products
SYNERAGalen PharmaN-021623 DISCN2005-06-23
1 products, RLD
PLIAGLISTaro PharmaceuticalN-021717 DISCN2006-06-29
1 products, RLD
Hide discontinued
Ceftriaxone sodium
Tradename
Company
Number
Date
Products
ROCEPHINRocheN-050585 DISCN1984-12-21
5 products, RLD
Hide discontinued
Ceftriaxone sodium
+
Lidocaine
Tradename
Company
Number
Date
Products
ROCEPHIN KITRocheN-050585 DISCN1996-05-08
2 products
Hide discontinued
Lidocaine
Tradename
Company
Number
Date
Products
ZTLIDOScilex PharmaceuticalsN-207962 RX2018-02-28
1 products, RLD, RS
LIDODERMTeikoku PharmaN-020612 RX1999-03-19
1 products, RLD, RS
Show 5 discontinued
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019830 RX1992-04-08
1 products
LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019830 RX1992-04-08
1 products
LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019830 RX1992-04-08
1 products
LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINERBaxterN-018461 RX1982-01-01
1 products
LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINERBaxterN-018461 RX1982-01-01
1 products
LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINERBaxterN-018461 RX1982-02-22
1 products
LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREEFresenius KabiN-017584 RX1982-01-01
2 products
XYLOCAINEFresenius KabiN-006488 RX1982-01-01
4 products, RLD, RS
ZINGOPowder PharmaceuticalsN-022114 RX2007-08-16
1 products
AKTENThea PharmaN-022221 RX2008-10-07
1 products, RLD, RS
Show 21 discontinued
Epinephrine
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
XYLOCAINE W/ EPINEPHRINEFresenius KabiN-006488 RX1982-01-01
6 products, RLD, RS
Show 6 discontinued
Dihydroergotamine mesylate
+
Heparin sodium
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
EMBOLEXNovartisN-018885 DISCN1984-11-30
2 products
Hide discontinued
Dexamethasone sodium phosphate
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
DECADRON W/ XYLOCAINEMerck & CoN-013334 DISCN1982-01-01
1 products
Hide discontinued
Bupivacaine hydrochloride
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
DUOCAINEAmphastar PharmaceuticalsN-021496 DISCN2003-05-23
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
aktenNew Drug Application2024-04-19
anestaconANDA2014-01-10
dentipatch2006-07-24
glydoANDA2022-01-31
leep redikitunapproved drug other2023-10-26
lidocaine hclANDA2013-05-31
lidocaine hydrochlorideNew Drug Application2022-07-13
lidodermNew Drug Application2022-12-02
lignospan forteANDA2024-02-05
lignospan standardANDA2024-02-08
Show 26 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
ventricular tachycardia—D017180I47.2
cardiac arrhythmiasEFO_0004269D001145I49.9
burns—D002056T30.0
esophageal diseasesEFO_0009544D004935K22.9
ventricular fibrillationEFO_0004287D014693I49.01
ventricular premature complexes—D018879I49.3
mouth diseasesEFO_1001047D009059K13
paroxysmal tachycardiaEFO_0009493D013614I47
sepsisEFO_0001420D018805A41.9
Show 93 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Lidocaine Hydrochloride, Zingo, Powder Pharms
93706222035-09-28U-1870
93583382035-04-27U-1870
85406652029-10-22U-1438
Lidocaine, Ztlido, Scilex Pharms
92831742031-05-10DP
99252642031-05-10DPU-2267
99314032031-05-10DP
107656402031-05-10DP
107657492031-05-10DP
112786232031-05-10DP
Lidocaine / Tetracaine, Pliaglis, Taro Pharms
103501802031-01-14DP
106032932031-01-14DP
107513052031-01-14DP
Lidocaine Hydrochloride, Akten, Thea Pharma
87594012026-07-24DPU-1523
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01B: Antiarrhythmics, class i and iii
— C01BB: Antiarrhythmics, class ib
— C01BB01: Lidocaine
— C05: Vasoprotectives
— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
— C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
— C05AD01: Lidocaine
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AB: Anesthetics for topical use
— D04AB01: Lidocaine
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BB: Amide local anesthetics
— N01BB02: Lidocaine
— N01BB52: Lidocaine, combinations
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AD: Local anesthetic throat preparations
— R02AD02: Lidocaine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01H: Local anesthetics, ophthalmologic
— S01HA: Local anesthetics
— S01HA07: Lidocaine
— S02: Otologicals
— S02D: Other otologicals in atc
— S02DA: Analgesics and anesthetics
— S02DA01: Lidocaine
HCPCS
Code
Description
C9285
Lidocaine 70 mg/tetracaine 70 mg, per patch
J2001
Injection, lidocaine hcl for intravenous infusion, 10 mg
Clinical
Clinical Trials
3586 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R521————1
Morton neuromaD000070607—G57.61————1
NeuromaD009463——1————1
NeuralgiaD009437EFO_0009430—1————1
Nociceptive painD059226——1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLidocaine
INNlidocaine
Description
Lidocaine is the monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline. It has a role as a local anaesthetic, an anti-arrhythmia drug, an environmental contaminant, a xenobiotic and a drug allergen. It is a monocarboxylic acid amide, a tertiary amino compound and a member of benzenes. It is functionally related to a glycinamide.
Classification
Small molecule
Drug classlocal anesthetics
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)CC(=O)Nc1c(C)cccc1C
Identifiers
PDB—
CAS-ID137-58-6
RxCUI—
ChEMBL IDCHEMBL79
ChEBI ID6456
PubChem CID3676
DrugBankDB00281
UNII ID98PI200987 (ChemIDplus, GSRS)
Target
Agency Approved
SCN5A
SCN5A
Organism
Homo sapiens
Gene name
SCN5A
Gene synonyms
NCBI Gene ID
6331
Protein name
sodium channel protein type 5 subunit alpha
Protein synonyms
cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit, hH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, sodium channel, voltage-gated, type V, alpha subunit, Voltage-gated sodium channel subunit alpha Nav1.5
Uniprot ID
Q14524
Mouse ortholog
Scn5a (20271)
sodium channel protein type 5 subunit alpha (Q9JJV9)
Alternate
TRPV6
TRPV6
SCN2A
SCN2A
SCN10A
SCN10A
Organism
Homo sapiens
Gene name
TRPV6
Gene synonyms
ECAC2
NCBI Gene ID
55503
Protein name
transient receptor potential cation channel subfamily V member 6
Protein synonyms
Alu-binding protein with zinc finger domain, Calcium transport protein 1, calcium transporter-like protein, CaT-L, CaT-like, CaT1, ECaC2, epithelial apical membrane calcium transporter/channel CaT1, Epithelial calcium channel 2
Uniprot ID
Q9H296
Mouse ortholog
Trpv6 (64177)
transient receptor potential cation channel subfamily V member 6 (Q91WD2)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Lidocaine – Amneal Pharmaceuticals
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Lidocaine – Amphastar Pharmaceuticals
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Rocephin – Roche
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Estimated US medical usage
Lidocaine
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Diphenhydramine
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Nystatin
Total medical expenditures per year (USD, in millions)
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Lidocaine
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Hydrocortisone
Total medical expenditures per year (USD, in millions)
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Lidocaine
Total medical expenditures per year (USD, in millions)
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Lidocaine
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Prilocaine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 91,136 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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31,740 adverse events reported
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