Decadron w/ xylocaine, Fortacin(lidocaine)
/ Lidocaine, Akten, Duocaine, Embolex, Fortacin, Glydo, Lanabiotic, Laryng-o-jet, Lidocaine, Lidocaine /, Lidoderm, Lignospan, Oraqix, Pliaglis, Rocephin, Synera, Terramycin, Xylocaine, Zingo, Ztlido (lidocaine) is a small molecule pharmaceutical. Lidocaine was first approved as Decadron w/ xylocaine on 1982-01-01. It is used to treat burns, cardiac arrhythmias, esophageal diseases, mouth diseases, and pain amongst others in the USA. It has been approved in Europe to treat physiological sexual dysfunction and premature ejaculation. The pharmaceutical is active against sodium channel protein type 5 subunit alpha. In addition, it is known to target sodium channel protein type 2 subunit alpha, sodium channel protein type 4 subunit alpha, sodium channel protein type 9 subunit alpha, and sodium channel protein type 10 subunit alpha.
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Events Timeline
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Akten, Lidoderm, Xylocaine, Zingo, Ztlido (generic drugs available since 1982-01-01, discontinued: Alphacaine, Anestacon, Dentipatch, Laryngotracheal anesthesia, Lidocaton, Lidopen, Lta, Rocephin, Xylocaine, Xylocaine viscous, Xylocaine w/ glucose)
CombinationsOraqix, Pliaglis (generic drugs available since 1982-01-01, discontinued: Decadron w/ xylocaine, Duocaine, Embolex, Emla, Iontocaine, Lanabiotic, Lidocaton, Lidosite topical system, Octocaine, Rocephin, Synera, Terramycin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bupivacaine hydrochloride
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Lidocaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUOCAINE | Amphastar Pharmaceuticals | N-021496 DISCN | 2003-05-23 | 1 products |
Hide discontinued
Ceftriaxone sodium
Ceftriaxone sodium
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Lidocaine
Dexamethasone sodium phosphate
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Lidocaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DECADRON W/ XYLOCAINE | Merck KGaA | N-013334 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Dihydroergotamine mesylate
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Heparin sodium
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Lidocaine hydrochloride
Epinephrine
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Lidocaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| XYLOCAINE W/ EPINEPHRINE | Fresenius Kabi | N-006488 RX | 1982-01-01 | 6 products, RLD, RS |
Show 6 discontinued
Lidocaine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZTLIDO | Scilex Pharmaceuticals | N-207962 RX | 2018-02-28 | 1 products, RLD, RS |
| LIDODERM | Teikoku Pharma | N-020612 RX | 1999-03-19 | 1 products, RLD, RS |
Show 5 discontinued
Lidocaine
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Prilocaine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ORAQIX | Dentsply Pharmaceutical | N-021451 RX | 2003-12-19 | 1 products, RLD, RS |
Show 2 discontinued
Lidocaine
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Tetracaine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PLIAGLIS | Taro Pharmaceutical | N-021717 RX | 2006-06-29 | 1 products, RLD, RS |
Show 1 discontinued
Lidocaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER | B. Braun Medical | N-019830 RX | 1992-04-08 | 1 products |
| LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER | B. Braun Medical | N-019830 RX | 1992-04-08 | 1 products |
| LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINER | B. Braun Medical | N-019830 RX | 1992-04-08 | 1 products |
| LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINER | Baxter | N-018461 RX | 1982-02-22 | 1 products |
| LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER | Baxter | N-018461 RX | 1982-01-01 | 1 products |
| LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER | Baxter | N-018461 RX | 1982-01-01 | 1 products |
| XYLOCAINE | Fresenius Kabi | N-006488 RX | 1982-01-01 | 4 products, RLD, RS |
| LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE | Fresenius Kabi | N-017584 RX | 1982-01-01 | 2 products |
| ZINGO | Powder Pharmaceuticals | N-022114 RX | 2007-08-16 | 1 products |
| AKTEN | Thea Pharma | N-022221 RX | 2008-10-07 | 1 products, RLD, RS |
Show 21 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 1% lidocaine hci | ANDA | 2024-01-30 |
| 10 person ansi | OTC monograph final | 2010-06-07 |
| 1st medxpatch | OTC monograph not final | 2023-09-28 |
| 2% lidocaine hci | ANDA | 2024-01-29 |
| 25 person ansi | OTC monograph final | 2010-06-07 |
| 3-step first aid kit | OTC monograph final | 2013-03-18 |
| 4017 first aid kit 4022 first aid kit | unapproved drug other | 2024-01-22 |
| 4032 first aid kit | unapproved drug other | 2024-01-22 |
| 4056 first aid kit 4068 first aid kit 4081 first aid kit 4082 first aid kit 4083 first aid kit 4084 first aid kit 4085 first aid kit 4086 first aid... | unapproved drug other | 2024-01-22 |
| 4064 first aid kit 4065 first aid kit 4066 first aid kit 4067 first aid kit | unapproved drug other | 2024-01-22 |
Show 376 more
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Lidocaine Hydrochloride, Zingo, Powder Pharms | |||
| 9370622 | 2035-09-28 | U-1870 | |
| 9358338 | 2035-04-27 | U-1870 | |
| 8540665 | 2029-10-22 | U-1438 | |
| Lidocaine, Ztlido, Scilex Pharms | |||
| 9283174 | 2031-05-10 | DP | |
| 9925264 | 2031-05-10 | DP | U-2267 |
| 9931403 | 2031-05-10 | DP | |
| 10765640 | 2031-05-10 | DP | |
| 10765749 | 2031-05-10 | DP | |
| 11278623 | 2031-05-10 | DP | |
| Lidocaine / Tetracaine, Pliaglis, Taro Pharms | |||
| 10350180 | 2031-01-14 | DP | |
| 10603293 | 2031-01-14 | DP | |
| 10751305 | 2031-01-14 | DP | |
| Lidocaine Hydrochloride, Akten, Thea Pharma | |||
| 8759401 | 2026-07-24 | DP | U-1523 |
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01B: Antiarrhythmics, class i and iii
— C01BB: Antiarrhythmics, class ib
— C01BB01: Lidocaine
— C05: Vasoprotectives
— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
— C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
— C05AD01: Lidocaine
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AB: Anesthetics for topical use
— D04AB01: Lidocaine
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BB: Amide local anesthetics
— N01BB02: Lidocaine
— N01BB52: Lidocaine, combinations
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AD: Local anesthetic throat preparations
— R02AD02: Lidocaine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01H: Local anesthetics, ophthalmologic
— S01HA: Local anesthetics
— S01HA07: Lidocaine
— S02: Otologicals
— S02D: Other otologicals in atc
— S02DA: Analgesics and anesthetics
— S02DA01: Lidocaine
Clinical
Clinical Trials
3488 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 14 | 38 | 39 | 73 | 134 | 285 |
| Postoperative pain | D010149 | — | G89.18 | 8 | 17 | 25 | 56 | 110 | 212 |
| Anesthesia | D000758 | — | — | 5 | 7 | 11 | 26 | 52 | 98 |
| Local anesthesia | D000772 | — | — | 5 | 10 | 13 | 20 | 39 | 84 |
| Analgesia | D000698 | — | — | 3 | 3 | 7 | 17 | 37 | 64 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 5 | 6 | 5 | 8 | 31 | 52 |
| Chronic pain | D059350 | HP_0012532 | — | 3 | 4 | 6 | 6 | 31 | 48 |
| Healthy volunteers/patients | — | — | — | 24 | 5 | 1 | 4 | 15 | 47 |
| Acute pain | D059787 | — | R52 | 2 | 6 | 4 | 10 | 22 | 41 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | 3 | 6 | 10 | 23 | 41 |
Show 347 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Interstitial cystitis | D018856 | EFO_1000869 | N30.1 | 2 | 12 | 2 | — | 3 | 19 |
| Aging | D000375 | GO_0007568 | R41.81 | — | 1 | 1 | — | 14 | 16 |
| Vulvodynia | D056650 | — | N94.81 | 1 | 3 | 2 | — | 7 | 13 |
| Cough | D003371 | HP_0012735 | R05 | 1 | 2 | 2 | — | 6 | 11 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 3 | 7 | — | — | 10 |
| Morbid obesity | D009767 | EFO_0001074 | — | — | 1 | 1 | — | 8 | 10 |
| Premature ejaculation | D061686 | HP_0012876 | F52.4 | 2 | 2 | 4 | — | 2 | 9 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 3 | 4 | — | 1 | 8 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | 1 | — | 7 | 8 |
| Temporomandibular joint disorders | D013705 | — | M26.6 | 1 | 3 | 1 | — | 3 | 7 |
Show 109 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperalgesia | D006930 | — | — | 1 | 5 | — | — | 1 | 7 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 1 | — | — | 5 | 6 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | 4 | 5 |
| Pruritus | D011537 | HP_0000989 | L29 | — | 1 | — | — | 4 | 5 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | 1 | — | — | 3 | 4 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 1 | — | — | 3 | 4 |
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | 1 | — | — | 3 | 4 |
| Mucositis | D052016 | EFO_1001898 | — | 1 | 3 | — | — | 1 | 4 |
| Malignant pleural effusion | D016066 | — | J91.0 | 3 | 1 | — | — | 1 | 4 |
| Chlamydia infections | D002690 | EFO_0007205 | A74.9 | — | 1 | — | — | 2 | 3 |
Show 88 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nociceptive pain | D059226 | — | — | 1 | — | — | — | 6 | 7 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | — | — | — | 5 | 6 |
| Morton neuroma | D000070607 | — | G57.6 | 2 | — | — | — | 3 | 5 |
| Asthma | D001249 | EFO_0000270 | J45 | 1 | — | — | — | 3 | 4 |
| Induced abortion | D000028 | — | — | 1 | — | — | — | 3 | 4 |
| Craniotomy | D003399 | — | — | 1 | — | — | — | 2 | 3 |
| Dental caries | D003731 | EFO_0003819 | K02 | 1 | — | — | — | 2 | 3 |
| Prostatic diseases | D011469 | — | N42.9 | 1 | — | — | — | 1 | 2 |
| Swine diseases | D013553 | — | — | 1 | — | — | — | 1 | 2 |
| Gingival recession | D005889 | — | K06.0 | 1 | — | — | — | 1 | 2 |
Show 16 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brachial plexus block | D065527 | — | — | — | — | — | — | 9 | 9 |
| Epidural analgesia | D015360 | — | — | — | — | — | — | 5 | 5 |
| Esthetics | D004954 | — | — | — | — | — | — | 5 | 5 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 5 | 5 |
| Basal cell carcinoma | D002280 | — | — | — | — | — | — | 5 | 5 |
| Basal cell neoplasms | D018295 | — | — | — | — | — | — | 5 | 5 |
| Piriformis muscle syndrome | D055958 | — | — | — | — | — | — | 5 | 5 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 5 | 5 |
| Needlestick injuries | D016602 | — | — | — | — | — | — | 5 | 5 |
| Ultrasonography | D014463 | — | — | — | — | — | — | 4 | 4 |
Show 314 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lidocaine |
| INN | lidocaine |
| Description | Lidocaine is the monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline. It has a role as a local anaesthetic, an anti-arrhythmia drug, an environmental contaminant, a xenobiotic and a drug allergen. It is a monocarboxylic acid amide, a tertiary amino compound and a member of benzenes. It is functionally related to a glycinamide. |
| Classification | Small molecule |
| Drug class | local anesthetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CC(=O)Nc1c(C)cccc1C |
Identifiers
| PDB | — |
| CAS-ID | 137-58-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL79 |
| ChEBI ID | 6456 |
| PubChem CID | 3676 |
| DrugBank | DB00281 |
| UNII ID | 98PI200987 (ChemIDplus, GSRS) |
Target
Agency Approved
SCN5A
SCN5A
Organism
Homo sapiens
Gene name
SCN5A
Gene synonyms
NCBI Gene ID
Protein name
sodium channel protein type 5 subunit alpha
Protein synonyms
cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit, hH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, sodium channel, voltage-gated, type V, alpha subunit, Voltage-gated sodium channel subunit alpha Nav1.5
Uniprot ID
Mouse ortholog
Scn5a (20271)
sodium channel protein type 5 subunit alpha (Q9JJV9)
Alternate
TRPV6
TRPV6
SCN2A
SCN2A
SCN10A
SCN10A
Organism
Homo sapiens
Gene name
TRPV6
Gene synonyms
ECAC2
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily V member 6
Protein synonyms
Alu-binding protein with zinc finger domain, Calcium transport protein 1, calcium transporter-like protein, CaT-L, CaT-like, CaT1, ECaC2, epithelial apical membrane calcium transporter/channel CaT1, Epithelial calcium channel 2
Uniprot ID
Mouse ortholog
Trpv6 (64177)
transient receptor potential cation channel subfamily V member 6 (Q91WD2)
Variants
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Financial
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Rocephin – Roche
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Lidocaine – Amneal Pharmaceuticals
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Lidocaine – Amphastar Pharmaceuticals
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Estimated US medical usage
Lidocaine
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Diphenhydramine
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Nystatin
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Lidocaine
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Hydrocortisone
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Lidocaine
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Lidocaine
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Prilocaine
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Trends
PubMed Central
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Additional graphs summarizing 85,254 documents
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Safety
Black-box Warning
Black-box warning for: Dexlido-m kit, Diclovix, Diclovix m, Duloxicaine, Dx1 oragenomic medicated dna collection screen, Dx2 oragenomic medicated dna collection screen, Dyural 40 kit, Dyural 80 kit, Dyural 80-lm, Dyural lm kit, Ketorocaine lm kit, Marbeta l kit, Marlido 25 kit, Marlido kit, Mlk f1 kit, Mlk f3 kit, Mlk f4 kit, Mlk kit f2, Readysharp anesthetics plus ketorolac
Adverse Events
Top Adverse Reactions
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29,208 adverse events reported
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