PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsIpilimumab
Yervoy(ipilimumab)
Yervoy (ipilimumab) is an antibody pharmaceutical. Ipilimumab was first approved as Yervoy on 2011-03-25. It is used to treat melanoma in the USA. It has been approved in Europe to treat colorectal neoplasms, malignant mesothelioma, melanoma, non-small-cell lung carcinoma, and renal cell carcinoma. The pharmaceutical is active against cytotoxic T-lymphocyte protein 4.
Download report
Favorite
Drugs Approved for Childhood Cancers
BMS
Top 200 Pharmaceuticals by Retail Sales
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
digestive system diseasesD004066
respiratory tract diseasesD012140
urogenital diseasesD000091642
Trade Name
FDA
EMA
Yervoy
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Ipilimumab
Tradename
Proper name
Company
Number
Date
Products
YervoyipilimumabBristol-Myers Squibb CompanyN-125377 RX2011-03-25
2 products
Labels
FDA
EMA
Brand Name
Status
Last Update
yervoyBiologic Licensing Application2023-02-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
melanoma—D008545—
Agency Specific
FDA
EMA
Expiration
Code
ipilimumab, Yervoy, Bristol-Myers Squibb Company
2027-10-02Orphan excl.
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01F: Monoclonal antibodies and antibody drug conjugates
— L01FX: Other monoclonal antibodies and antibody drug conjugates in atc
— L01FX04: Ipilimumab
HCPCS
Code
Description
J9228
Injection, ipilimumab, 1 mg
Clinical
Clinical Trials
882 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanomaD008545——10514819241274
Renal cell carcinomaD002292EFO_0000376—2229611063
Lung neoplasmsD008175HP_0100526C34.90101651328
Kidney neoplasmsD007680EFO_0003865C642721819
Biliary liver cirrhosisD008105—K74.3———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C8064624—6105
Non-small-cell lung carcinomaD002289——324815—784
Prostatic neoplasmsD011471—C6114232——37
Colorectal neoplasmsD015179——14184—131
Pancreatic neoplasmsD010190EFO_0003860C2517161——28
Breast neoplasmsD001943EFO_0003869C5012151—125
Squamous cell carcinoma of head and neckD000077195——11112——21
Liver neoplasmsD008113EFO_1001513C22.010123——20
Hepatocellular carcinomaD006528—C22.08123——19
GlioblastomaD005909EFO_0000515—882—117
Show 20 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Uveal neoplasmsD014604EFO_1001230—1314———23
Non-hodgkin lymphomaD008228—C85.996———12
AdenocarcinomaD000230——28——111
Myelodysplastic syndromesD009190—D4692———11
Myeloid leukemia acuteD015470—C92.0101———11
Urologic neoplasmsD014571—C64-C6885——111
Multiple myelomaD009101—C90.075———10
LymphomaD008223—C85.994———10
Castration-resistant prostatic neoplasmsD064129——45———9
B-cell chronic lymphocytic leukemiaD015451—C91.182———8
Show 118 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340—4————4
Leukemia myeloid chronic atypical bcr-abl negativeD054438—C92.23————3
Hematologic neoplasmsD019337——2————2
Primary myelofibrosisD055728—D47.42————2
Healthy volunteers/patients———1———12
Large-cell lymphoma anaplasticD017728—C84.62————2
T-cell lymphoma peripheralD016411——2————2
Ovarian epithelial carcinomaD000077216——2————2
AnemiaD000740HP_0001903D64.91————1
Myeloid leukemia chronic-phaseD015466——1————1
Show 19 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Autoimmune diseasesD001327HP_0002960M30-M36————33
Heart diseasesD006331EFO_0003777I51.9————22
MyocarditisD009205—I51.4————22
Drug-related side effects and adverse reactionsD064420—T88.7————22
MicrobiotaD064307——————22
MetagenomeD054892——————22
Cardiovascular diseasesD002318HP_0001626—————11
CardiomyopathiesD009202EFO_0000318I42————11
PericarditisD010493EFO_0007427I30————11
VasculitisD014657HP_0002633—————11
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameIpilimumab
INNipilimumab
Description
Ipilimumab (human mab)
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
>7SU0:H,I|Fab heavy chain (PCA)VQLVESGGGVVQPGRSLRLSCAASGFTFSHYTMHWVRQAPGKGLEWVTFISYDGHNKYYADSVKGRFTISRDNSK NTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGHHHHHH >7SU0:L,M|Fab light chain EIVLTQSPGTLSLSPGERATLSCRASQEVGESELAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLE PEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Identifiers
PDB5TRU, 5XJ3, 6JC2, 6RP8, 7SU0, 7SU1
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL1789844
ChEBI ID—
PubChem CID—
DrugBankDB06186
UNII ID6T8C155666 (ChemIDplus, GSRS)
Target
Agency Approved
CTLA4
CTLA4
Organism
Homo sapiens
Gene name
CTLA4
Gene synonyms
CD152
NCBI Gene ID
1493
Protein name
cytotoxic T-lymphocyte protein 4
Protein synonyms
CD152, celiac disease 3, CTLA-4, cytotoxic T lymphocyte associated antigen 4 short spliced form, Cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte-associated serine esterase-4, gluten-sensitive enteropathy, insulin-dependent diabetes mellitus 12, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Uniprot ID
P16410
Mouse ortholog
Ctla4 (12477)
cytotoxic T-lymphocyte protein 4 (P09793)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Yervoy – Bristol Myers Squibb
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 42,099 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
27,931 adverse events reported
View more details
© 2020-2023 Collaborative Drug Discovery Inc. (CDD) | Terms of Use