Yervoy(ipilimumab)
Yervoy (ipilimumab) is an antibody pharmaceutical. Ipilimumab was first approved as Yervoy on 2011-03-25. It is used to treat melanoma in the USA. It has been approved in Europe to treat colorectal neoplasms, malignant mesothelioma, melanoma, non-small-cell lung carcinoma, and renal cell carcinoma. The pharmaceutical is active against cytotoxic T-lymphocyte protein 4.
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Yervoy
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Ipilimumab
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Yervoy | ipilimumab | Bristol Myers Squibb | N-125377 RX | 2011-03-25 | 2 products |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| yervoy | Biologic Licensing Application | 2026-08-20 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ipilimumab, Yervoy, Bristol-Myers Squibb Company | |||
| 2027-10-02 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9228 | Injection, ipilimumab, 1 mg |
Clinical
Clinical Trials
978 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 124 | 182 | 26 | 2 | 54 | 334 |
| Neoplasms | D009369 | — | C80 | 83 | 77 | 5 | 2 | 14 | 140 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 34 | 44 | 8 | 2 | 17 | 93 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 37 | 32 | 4 | 1 | 3 | 59 |
| Lung neoplasms | D008175 | — | C34.90 | 16 | 24 | 7 | 1 | 8 | 47 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 10 | 11 | 5 | 2 | 9 | 34 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 9 | 11 | 4 | 1 | 3 | 24 |
| Immunotherapy | D007167 | — | — | 1 | 2 | — | 1 | 4 | 7 |
| Oncogenes | D009857 | — | — | — | — | — | 1 | — | 1 |
| Radiotherapy | D011878 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 43 | 64 | 17 | — | 16 | 114 |
| Prostatic neoplasms | D011471 | — | C61 | 15 | 25 | 3 | — | 1 | 40 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 21 | 22 | 1 | — | 2 | 37 |
| Colorectal neoplasms | D015179 | — | — | 19 | 21 | 4 | — | 2 | 36 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 16 | 20 | 6 | — | 3 | 34 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 13 | 17 | 6 | — | 1 | 28 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 10 | 19 | 1 | — | 1 | 28 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | 15 | 17 | 3 | — | — | 28 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 13 | 15 | 1 | — | 1 | 26 |
| Uveal melanoma | D000098943 | — | — | 15 | 15 | 3 | — | — | 26 |
Show 28 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Triple negative breast neoplasms | D064726 | — | — | 12 | 11 | — | — | — | 16 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 10 | 6 | — | — | — | 13 |
| Urologic neoplasms | D014571 | — | C64-C68 | 9 | 6 | — | — | 1 | 12 |
| Lymphoma | D008223 | — | C85.9 | 10 | 5 | — | — | — | 12 |
| Myelodysplastic syndromes | D009190 | — | D46 | 9 | 2 | — | — | — | 11 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 10 | 1 | — | — | — | 11 |
| Multiple myeloma | D009101 | — | C90.0 | 8 | 6 | — | — | — | 11 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 9 | 2 | — | — | — | 9 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 4 | 4 | — | — | — | 8 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 8 | 1 | — | — | — | 8 |
Show 144 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloproliferative disorders | D009196 | — | D47.1 | 5 | — | — | — | — | 5 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 4 | — | — | — | — | 4 |
| Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | 1 | — | — | — | 3 | 4 |
| Leukemia myeloid chronic atypical bcr-abl negative | D054438 | — | C92.2 | 3 | — | — | — | — | 3 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 1 | 3 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 3 | — | — | — | — | 3 |
| Motor activity | D009043 | EFO_0003940 | — | 1 | — | — | — | 2 | 3 |
| Primary myelofibrosis | D055728 | — | D47.4 | 2 | — | — | — | — | 2 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 2 | — | — | — | — | 2 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 2 | — | — | — | — | 2 |
Show 54 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocarditis | D009205 | — | I51.4 | — | — | — | — | 3 | 3 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 3 | 3 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 2 | 2 |
| Microbiota | D064307 | — | — | — | — | — | — | 2 | 2 |
| Metagenome | D054892 | — | — | — | — | — | — | 2 | 2 |
| Multiple primary neoplasms | D009378 | — | — | — | — | — | — | 2 | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 1 | 1 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | — | 1 | 1 |
| Pericarditis | D010493 | EFO_0007427 | I30 | — | — | — | — | 1 | 1 |
| Vasculitis | D014657 | EFO_0006803 | M31 | — | — | — | — | 1 | 1 |
Show 11 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ipilimumab |
| INN | ipilimumab |
| Description | Ipilimumab (human mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >7SU0:H,I|Fab heavy chain
(PCA)VQLVESGGGVVQPGRSLRLSCAASGFTFSHYTMHWVRQAPGKGLEWVTFISYDGHNKYYADSVKGRFTISRDNSK
NTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT
VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGHHHHHH
>7SU0:L,M|Fab light chain
EIVLTQSPGTLSLSPGERATLSCRASQEVGESELAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLE
PEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 5TRU, 5XJ3, 6JC2, 6RP8, 7SU0, 7SU1 |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1789844 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB06186 |
| UNII ID | 6T8C155666 (ChemIDplus, GSRS) |
Target
Agency Approved
CTLA4
CTLA4
Organism
Homo sapiens
Gene name
CTLA4
Gene synonyms
CD152
NCBI Gene ID
Protein name
cytotoxic T-lymphocyte protein 4
Protein synonyms
CD152, celiac disease 3, CTLA-4, cytotoxic T lymphocyte associated antigen 4 short spliced form, Cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte-associated serine esterase-4, gluten-sensitive enteropathy, insulin-dependent diabetes mellitus 12, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Uniprot ID
Mouse ortholog
Ctla4 (12477)
cytotoxic T-lymphocyte protein 4 (P09793)
Alternate
No data
Variants
No data
Financial
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Yervoy – Bristol Myers Squibb
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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46,096 adverse events reported
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