Hydroflumethiazide
Diucardin, Saluron, Salutensin, Salutensin-demi (hydroflumethiazide) is a small molecule pharmaceutical. Hydroflumethiazide was first approved as Saluron on 1982-01-01. It is used to treat edema, glomerulonephritis, heart failure, hypertension, and liver cirrhosis amongst others in the USA.
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Hydroflumethiazide
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| saluron | 2006-07-19 |
Indications
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ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03A: Low-ceiling diuretics, thiazides
— C03AA: Thiazides, plain
— C03AA02: Hydroflumethiazide
— C03AB: Thiazides and potassium in combination
— C03AB02: Hydroflumethiazide and potassium
— C03AH: Thiazides, combinations with psycholeptics and/or analgesics
— C03AH02: Hydroflumethiazide, combinations
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Clinical
Indications Phases 4
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hydroflumethiazide |
| INN | hydroflumethiazide |
| Description | Hydroflumethiazide is a benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a thiazide. |
| Classification | Small molecule |
| Drug class | diuretics (thiazide derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NCNS2(=O)=O |
Identifiers
| PDB | — |
| CAS-ID | 135-09-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1763 |
| ChEBI ID | 5784 |
| PubChem CID | 3647 |
| DrugBank | DB00774 |
| UNII ID | 501CFL162R (ChemIDplus, GSRS) |
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Hydroflumethiazide
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Hydroflumethiazide
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Safety
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11 adverse events reported
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